HUMAN THROMBIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 00:43:24 GMT 2023` Edited by `admin` on `Sat Dec 16 00:43:24 GMT 2023`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	6K15ABL77G
Record Status	`Validated (UNII)`
Record Version

Download

Related Record	Type

Name

Type

Language

HUMAN THROMBIN

Common Name

English

THROMBIN HUMAN

Preferred Name

English

THROMBIN (HUMAN) (FOR FURTHER MANUFACTURING USE)

Common Name

English

THROMBIN TOPICAL HUMAN

Common Name

English

HUMAN THROMBIN [EMA EPAR]

Common Name

English

THROMBIN HUMAN PLASMA-DERIVED

Common Name

English

THROMBIN [MI]

Common Name

English

THROMBIN (HUMAN)

Common Name

English

COAGULATION FACTOR IIA

Common Name

English

ARTISS COMPONENT HUMAN THROMBIN

Brand Name

English

Classification Tree Code System Code

EMA ASSESSMENT REPORTS

EVICEL (AUTHORIZED: HEMOSTASIS, REGULATORY)

Created by admin on Sat Dec 16 00:43:25 GMT 2023 , Edited by admin on Sat Dec 16 00:43:25 GMT 2023

EMA ASSESSMENT REPORTS

RAPLIXA (AUTHORIZED: HEMOSTASIS, SURGICAL)

Created by admin on Sat Dec 16 00:43:25 GMT 2023 , Edited by admin on Sat Dec 16 00:43:25 GMT 2023

EMA ASSESSMENT REPORTS

TACHOSIL (AUTHORIZED: HEMOSTASIS, SURGICAL)

Created by admin on Sat Dec 16 00:43:25 GMT 2023 , Edited by admin on Sat Dec 16 00:43:25 GMT 2023

NCI_THESAURUS

C78311

Created by admin on Sat Dec 16 00:43:25 GMT 2023 , Edited by admin on Sat Dec 16 00:43:25 GMT 2023

NDF-RT

N0000184169

Created by admin on Sat Dec 16 00:43:25 GMT 2023 , Edited by admin on Sat Dec 16 00:43:25 GMT 2023

Code System Code Type Description

RXCUI

825006

Created by admin on Sat Dec 16 00:43:25 GMT 2023 , Edited by admin on Sat Dec 16 00:43:25 GMT 2023

PRIMARY

RxNorm

EVMPD

SUB20551

Created by admin on Sat Dec 16 00:43:25 GMT 2023 , Edited by admin on Sat Dec 16 00:43:25 GMT 2023

PRIMARY

SMS_ID

100000092746

Created by admin on Sat Dec 16 00:43:25 GMT 2023 , Edited by admin on Sat Dec 16 00:43:25 GMT 2023

PRIMARY

NDF-RT

N0000009252

Created by admin on Sat Dec 16 00:43:25 GMT 2023 , Edited by admin on Sat Dec 16 00:43:25 GMT 2023

PRIMARY

Increased Coagulation Factor Activity [PE]

NCI_THESAURUS

C81121

Created by admin on Sat Dec 16 00:43:25 GMT 2023 , Edited by admin on Sat Dec 16 00:43:25 GMT 2023

PRIMARY

DRUG BANK

DB11571

Created by admin on Sat Dec 16 00:43:25 GMT 2023 , Edited by admin on Sat Dec 16 00:43:25 GMT 2023

PRIMARY

DAILYMED

6K15ABL77G

Created by admin on Sat Dec 16 00:43:25 GMT 2023 , Edited by admin on Sat Dec 16 00:43:25 GMT 2023

PRIMARY

NDF-RT

N0000007914

Created by admin on Sat Dec 16 00:43:25 GMT 2023 , Edited by admin on Sat Dec 16 00:43:25 GMT 2023

PRIMARY

Blood Coagulation Factors [Chemical/Ingredient]

CAS

9002-04-4

Created by admin on Sat Dec 16 00:43:25 GMT 2023 , Edited by admin on Sat Dec 16 00:43:25 GMT 2023

PRIMARY

MERCK INDEX

m10807

Created by admin on Sat Dec 16 00:43:25 GMT 2023 , Edited by admin on Sat Dec 16 00:43:25 GMT 2023

PRIMARY

Merck Index

FDA UNII

6K15ABL77G

Created by admin on Sat Dec 16 00:43:25 GMT 2023 , Edited by admin on Sat Dec 16 00:43:25 GMT 2023

PRIMARY

From	To
1_28	1_44
1_119	2_9
1_173	1_187
1_201	1_231

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_53

Related Record Type Details


					2WA50NUH6H

INHIBITOR -> TARGET

Amount:


					TN9BEX005G

INHIBITOR -> TARGET


					FS64O4K98A

LB-30870

INHIBITOR -> TARGET

Amount:


					428409I84L

INOGATRAN

INHIBITOR -> TARGET

Amount:


					IF979JQU3S

LB-30057 FREE BASE

INHIBITOR -> TARGET

THROMBIN, TOPICAL (HUMAN)

SUB_CONCEPT->SUBSTANCE


					I0VM4M70GC

INHIBITOR -> TARGET

Amount:


					VT0VK2474K

EFEGATRAN

INHIBITOR -> TARGET

Amount:


					497U7679T0

INHIBITOR -> TARGET

Amount:


					Y43GF64R34

LEPIRUDIN

INHIBITOR -> TARGET


					5X6P105U1Y

INHIBITOR -> TARGET

Amount:


					X5QRR6Z56Q

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					84K87A0AJE

NAPSAGATRAN ANHYDROUS

INHIBITOR -> TARGET

Comments:

Napsagatran [RO 466240], a reversible and highly selective thrombin inhibitor, was in development with Roche for use in myocardial infarction and thrombosis. Napsagatran efficiently inhibits and delays thrombin generation in human coagulating plasma. This reduced thrombin generation might be caused by inhibition of thrombin-mediated feedback reactions during blood coagulation. Ro 46-6240 inhibited clot-bound thrombin three times more potently than fluid-phase thrombin (IC50 19 vs 56 ng/ml) while hirudin was two times (IC50 8 vs 3 ng/ml) and heparin six times (IC50 1,205 vs 200 ng/ml) less active against clot-bound thrombin compared with fluid-phase thrombin.

Amount:


					UW0H6X9FSQ

INHIBITOR -> TARGET

Amount:


					OCY3U280Y3

ARGATROBAN ANHYDROUS

INHIBITOR -> TARGET

Comments:

Argatroban is capable of inhibiting the action of both free and clot-associated thrombin.

Qualification:

Ki

Amount:


					MNY7X23SRZ

HIRUDIN

INHIBITOR -> TARGET


					S6MPG81Y84

DPOC-4088

INHIBITOR -> TARGET

Amount:


					2A9QP32MD4

INHIBITOR -> TARGET

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL