U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 00:43:24 UTC 2023
Edited
by admin
on Sat Dec 16 00:43:24 UTC 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
6K15ABL77G
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
Name Type Language
HUMAN THROMBIN
EMA EPAR  
Common Name English
THROMBIN HUMAN
Preferred Name English
THROMBIN (HUMAN) (FOR FURTHER MANUFACTURING USE)
Common Name English
THROMBIN TOPICAL HUMAN
Common Name English
HUMAN THROMBIN [EMA EPAR]
Common Name English
THROMBIN HUMAN PLASMA-DERIVED
Common Name English
THROMBIN [MI]
Common Name English
THROMBIN (HUMAN)
Common Name English
COAGULATION FACTOR IIA
Common Name English
ARTISS COMPONENT HUMAN THROMBIN
Brand Name English
Classification Tree Code System Code
EMA ASSESSMENT REPORTS EVICEL (AUTHORIZED: HEMOSTASIS, REGULATORY)
Created by admin on Sat Dec 16 00:43:25 UTC 2023 , Edited by admin on Sat Dec 16 00:43:25 UTC 2023
EMA ASSESSMENT REPORTS RAPLIXA (AUTHORIZED: HEMOSTASIS, SURGICAL)
Created by admin on Sat Dec 16 00:43:25 UTC 2023 , Edited by admin on Sat Dec 16 00:43:25 UTC 2023
EMA ASSESSMENT REPORTS TACHOSIL (AUTHORIZED: HEMOSTASIS, SURGICAL)
Created by admin on Sat Dec 16 00:43:25 UTC 2023 , Edited by admin on Sat Dec 16 00:43:25 UTC 2023
NCI_THESAURUS C78311
Created by admin on Sat Dec 16 00:43:25 UTC 2023 , Edited by admin on Sat Dec 16 00:43:25 UTC 2023
NDF-RT N0000184169
Created by admin on Sat Dec 16 00:43:25 UTC 2023 , Edited by admin on Sat Dec 16 00:43:25 UTC 2023
Code System Code Type Description
RXCUI
825006
Created by admin on Sat Dec 16 00:43:25 UTC 2023 , Edited by admin on Sat Dec 16 00:43:25 UTC 2023
PRIMARY RxNorm
EVMPD
SUB20551
Created by admin on Sat Dec 16 00:43:25 UTC 2023 , Edited by admin on Sat Dec 16 00:43:25 UTC 2023
PRIMARY
SMS_ID
100000092746
Created by admin on Sat Dec 16 00:43:25 UTC 2023 , Edited by admin on Sat Dec 16 00:43:25 UTC 2023
PRIMARY
NDF-RT
N0000009252
Created by admin on Sat Dec 16 00:43:25 UTC 2023 , Edited by admin on Sat Dec 16 00:43:25 UTC 2023
PRIMARY Increased Coagulation Factor Activity [PE]
NCI_THESAURUS
C81121
Created by admin on Sat Dec 16 00:43:25 UTC 2023 , Edited by admin on Sat Dec 16 00:43:25 UTC 2023
PRIMARY
DRUG BANK
DB11571
Created by admin on Sat Dec 16 00:43:25 UTC 2023 , Edited by admin on Sat Dec 16 00:43:25 UTC 2023
PRIMARY
DAILYMED
6K15ABL77G
Created by admin on Sat Dec 16 00:43:25 UTC 2023 , Edited by admin on Sat Dec 16 00:43:25 UTC 2023
PRIMARY
NDF-RT
N0000007914
Created by admin on Sat Dec 16 00:43:25 UTC 2023 , Edited by admin on Sat Dec 16 00:43:25 UTC 2023
PRIMARY Blood Coagulation Factors [Chemical/Ingredient]
CAS
9002-04-4
Created by admin on Sat Dec 16 00:43:25 UTC 2023 , Edited by admin on Sat Dec 16 00:43:25 UTC 2023
PRIMARY
MERCK INDEX
m10807
Created by admin on Sat Dec 16 00:43:25 UTC 2023 , Edited by admin on Sat Dec 16 00:43:25 UTC 2023
PRIMARY Merck Index
FDA UNII
6K15ABL77G
Created by admin on Sat Dec 16 00:43:25 UTC 2023 , Edited by admin on Sat Dec 16 00:43:25 UTC 2023
PRIMARY
From To
1_28 1_44
1_119 2_9
1_173 1_187
1_201 1_231
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_53
Related Record Type Details
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
SUB_CONCEPT->SUBSTANCE
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
Napsagatran [RO 466240], a reversible and highly selective thrombin inhibitor, was in development with Roche for use in myocardial infarction and thrombosis. Napsagatran efficiently inhibits and delays thrombin generation in human coagulating plasma. This reduced thrombin generation might be caused by inhibition of thrombin-mediated feedback reactions during blood coagulation. Ro 46-6240 inhibited clot-bound thrombin three times more potently than fluid-phase thrombin (IC50 19 vs 56 ng/ml) while hirudin was two times (IC50 8 vs 3 ng/ml) and heparin six times (IC50 1,205 vs 200 ng/ml) less active against clot-bound thrombin compared with fluid-phase thrombin.
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Argatroban is capable of inhibiting the action of both free and clot-associated thrombin.
Ki
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL