Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H17N3S.ClH |
| Molecular Weight | 319.852 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CN(C)CC1=CC=CC=C1SC2=CC=C(C=C2N)C#N
InChI
InChIKey=NGUQWWFTYNJBAF-UHFFFAOYSA-N
InChI=1S/C16H17N3S.ClH/c1-19(2)11-13-5-3-4-6-15(13)20-16-8-7-12(10-17)9-14(16)18;/h3-9H,11,18H2,1-2H3;1H
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C16H17N3S |
| Molecular Weight | 283.391 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Positron emission tomography quantification of [(11)C]-DASB binding to the human serotonin transporter: modeling strategies. | 2001 Nov |
|
| Comparative evaluation of serotonin transporter radioligands 11C-DASB and 11C-McN 5652 in healthy humans. | 2004 Apr |
|
| Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study. | 2004 May |
|
| DASB -in vitro binding characteristics on human recombinant monoamine transporters with regard to its potential as positron emission tomography (PET) tracer. | 2004 Sep |
|
| Potential of [11C]DASB for measuring endogenous serotonin with PET: binding studies. | 2005 Feb |
|
| Serotonin transporter availability in patients with schizophrenia: a positron emission tomography imaging study with [11C]DASB. | 2005 Jun 15 |
|
| Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone. | 2005 Mar 7 |
|
| Time course of in vivo 5-HTT transporter occupancy by fluvoxamine. | 2006 Apr |
|
| Novel 5-HTTLPR allele associates with higher serotonin transporter binding in putamen: a [(11)C] DASB positron emission tomography study. | 2007 Aug 15 |
|
| Human 5-HT transporter availability predicts amygdala reactivity in vivo. | 2007 Aug 22 |
|
| Misunderstandings about how to choose a reference region. | 2007 Jun 1 |
|
| Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder. | 2007 Oct 15 |
|
| Relationship between neuroticism personality trait and serotonin transporter binding. | 2007 Sep 15 |
|
| Evaluation of non-uniform weighting in non-linear regression for pharmacokinetic neuroreceptor modelling. | 2008 Feb |
|
| Anxiety is associated with reduced central serotonin transporter availability in unmedicated patients with unipolar major depression: a [11C]DASB PET study. | 2008 Jun |
|
| Elevated serotonin transporter binding in depressed patients with Parkinson's disease: a preliminary PET study with [11C]DASB. | 2008 Sep 15 |
|
| Serotonin transporter binding and genotype in the nonhuman primate brain using [C-11]DASB PET. | 2009 Oct 1 |
|
| Utility of small-animal positron emission tomographic imaging of rats for preclinical development of drugs acting on the serotonin transporter. | 2009 Sep |
|
| Mapping of serotonin transporters by positron emission tomography with [11C]DASB in conscious common marmosets: comparison with rhesus monkeys. | 2010 Aug |
|
| Reduced serotonin transporter binding in the insular cortex in patients with obsessive-compulsive disorder: a [11C]DASB PET study. | 2010 Jan 1 |
|
| Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels. | 2010 Nov |
|
| Depressive symptoms in PD correlate with higher 5-HTT binding in raphe and limbic structures. | 2010 Nov 23 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 19:37:49 GMT 2023
by
admin
on
Fri Dec 15 19:37:49 GMT 2023
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| Record UNII |
6JUA5M5RFV
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| Record Status |
Validated (UNII)
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| Record Version |
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44153791
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6JUA5M5RFV
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DTXSID10958381
Created by
admin on Fri Dec 15 19:37:49 GMT 2023 , Edited by admin on Fri Dec 15 19:37:49 GMT 2023
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371971-10-7
Created by
admin on Fri Dec 15 19:37:49 GMT 2023 , Edited by admin on Fri Dec 15 19:37:49 GMT 2023
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PARENT -> SALT/SOLVATE |
