TYROSINE-PROTEIN KINASE ZAP-70

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 18:41:01 GMT 2025` Edited by `admin` on `Tue Apr 01 18:41:01 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	6JBZ59HNQ7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TYROSINE-PROTEIN KINASE ZAP-70

Common Name

English

70 KDA ZETA-CHAIN ASSOCIATED PROTEIN

Preferred Name

English

SRK

Common Name

English

ZAP70

Common Name

English

SYK-RELATED TYROSINE KINASE

Common Name

English

Code System Code Type Description

UNIPROT

P43403

Created by admin on Tue Apr 01 18:41:01 GMT 2025 , Edited by admin on Tue Apr 01 18:41:01 GMT 2025

PRIMARY

PHAROS

P43403

Created by admin on Tue Apr 01 18:41:01 GMT 2025 , Edited by admin on Tue Apr 01 18:41:01 GMT 2025

PRIMARY

WIKIPEDIA

ZAP70

Created by admin on Tue Apr 01 18:41:01 GMT 2025 , Edited by admin on Tue Apr 01 18:41:01 GMT 2025

PRIMARY

FDA UNII

6JBZ59HNQ7

Created by admin on Tue Apr 01 18:41:01 GMT 2025 , Edited by admin on Tue Apr 01 18:41:01 GMT 2025

PRIMARY

Related Record Type Details


					RC3A285J2G

TAMATINIB

INHIBITOR -> TARGET

Comments:

R406 bound to the ATP binding pocket of Syk and inhibited its kinase activity as an ATP-competitive inhibitor.

Interaction Type:

COMPETITIVE INHIBITOR

Qualification:

Ki

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_289]				DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL
Molecular Formula	CHEMICAL