Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C6H16NO |
| Molecular Weight | 118.1973 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 1 |
SHOW SMILES / InChI
SMILES
CC[N+](C)(C)CCO
InChI
InChIKey=VKHSBLZDXXEWNM-UHFFFAOYSA-N
InChI=1S/C6H16NO/c1-4-7(2,3)5-6-8/h8H,4-6H2,1-3H3/q+1
| Molecular Formula | C6H15NO |
| Molecular Weight | 117.1894 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer's disease. | 2010-03 |
|
| Increases in serotonergic neuronal activity following intracerebroventricular administration of AF64A in rats. | 2010-02 |
|
| Nicotine improves AF64A-induced spatial memory deficits in Morris water maze in rats. | 2010-01-18 |
|
| Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer's disease model. | 2010-01-08 |
|
| Effects of estrogen on AF64A-induced apoptosis in NG108-15 cells. | 2009-11-10 |
|
| The effects of rivastigmine plus selegiline on brain acetylcholinesterase, (Na, K)-, Mg-ATPase activities, antioxidant status, and learning performance of aged rats. | 2008-08 |
|
| MKC-231, a choline uptake enhancer: (3) Mode of action of MKC-231 in the enhancement of high-affinity choline uptake. | 2008-07 |
|
| MKC-231, a choline-uptake enhancer: (1) long-lasting cognitive improvement after repeated administration in AF64A-treated rats. | 2008-07 |
|
| MKC-231, a choline uptake enhancer: (2) Effect on synthesis and release of acetylcholine in AF64A-treated rats. | 2008-07 |
|
| The role of the nucleus basalis of Meynert and reticular thalamic nucleus in pathogenesis of genetically determined absence epilepsy in rats: a lesion study. | 2007-12-14 |
|
| Differential expression of inflammatory and fibrogenic genes and their regulation by NF-kappaB inhibition in a mouse model of chronic colitis. | 2007-11-15 |
|
| Phosphatidylinositol 3-Akt-kinase-dependent phosphorylation of p21(Waf1/Cip1) as a novel mechanism of neuroprotection by glucocorticoids. | 2007-04-25 |
|
| Effects of luteolin on learning acquisition in rats: involvement of the central cholinergic system. | 2007-04-10 |
|
| FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells. | 2007-02-15 |
|
| Effects of selegiline alone or with donepezil on memory impairment in rats. | 2005-08-22 |
|
| Low intracerebroventricular doses of cholinotoxin AF64A do not affect the morphology of gonadotropin hormone-releasing hormone (GnRH)-immunoreactive fibers in the rat septum. | 2005-07-12 |
|
| Low molecular weight glycosaminoglycan C3 attenuates AF64A-stimulated, low-affinity nerve growth factor receptor-immunoreactive axonal varicosities in the rat septum. | 2005-02-01 |
|
| Glycosaminoglycan C3 protects against AF64A-induced cholinotoxicity in a dose-dependent and time-dependent manner. | 2004-07-23 |
|
| The effects of estrogens on learning in rats with chronic brain cholinergic deficiency in a Morris water test. Identification of the "passive swimming" component. | 2004-03 |
|
| Protection against inflammatory neurodegeneration and glial cell death by 7beta-hydroxy epiandrosterone, a novel neurosteroid. | 2004-03 |
|
| Neuronal gelsolin prevents apoptosis by enhancing actin depolymerization. | 2004-01 |
|
| Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury. | 2003-07 |
|
| [Effects of estrogens on learning of rats with chronic brain cholinergic deficit in Morris water maze]. | 2003-05-21 |
|
| [Cholinergic mechanisms in the pathogenesis of genetically-caused absence epilepsy]. | 2003-03-15 |
|
| Dose-dependent effect of cholinotoxin AF64A on the cholinergic elements of the cingulum bundle in rat. | 2003-03-07 |
|
| Role of NAD(P)H:quinone oxidoreductase in the progression of neuronal cell death in vitro and following cerebral ischaemia in vivo. | 2003-03 |
|
| Protective effect of the heparin-derived oligosaccharide C3, on AF64A-induced cholinergic lesion in rats. | 2003-02-26 |
|
| Effects of the destruction of starburst-cholinergic amacrine cells by the toxin AF64A on rabbit retinal directional selectivity. | 2003-01-04 |
|
| Comparison of the effect of NT-0409 and antidementia drugs on learning and memory in rats with chronic cerebral cholinergic deficiency. | 2003-01 |
|
| Effect of morphine-induced antinociception is altered by AF64A-induced lesions on cholinergic neurons in rat nucleus raphe magnus. | 2002-11 |
|
| Effects of repeated administration of (-)-nicotine on AF64A-induced learning and memory impairment in rats. | 2002-03 |
|
| Influences of cholinergic neurotoxin ethylcholine aziridinium ion on circadian rhythms in rats. | 2001-12 |
|
| Spinal endogenous acetylcholine contributes to the analgesic effect of systemic morphine in rats. | 2001-08 |
|
| Serotonergic lesion of median raphe nucleus alters nerve growth factor content and vulnerability of cholinergic septohippocampal neurons in rat. | 2001-07-13 |
|
| An obligatory role for spinal cholinergic neurons in the antiallodynic effects of clonidine after peripheral nerve injury. | 2001-06 |
|
| Neuroprotective and cognition-enhancing properties of MK-801 flexible analogs. Structure-activity relationships. | 2001-06 |
|
| Impairments of learning and memory following intracerebroventricular administration of AF64A in rats. | 2001-06 |
|
| Differential mechanisms of neuroprotection by 17 beta-estradiol in apoptotic versus necrotic neurodegeneration. | 2001-04-15 |
|
| Effect of AF64A, a cholinergic neurotoxin, on footshock stimulation-induced locus coeruleus excitation in rats. | 2001-04-13 |
|
| Role of cholinergic mossy fibers in vestibular nuclei in the development of vestibular compensation. | 2001 |
|
| Role of cholinergic mossy fibers in medial vestibular and prepositus hypoglossal nuclei in vestibular compensation. | 2001 |
|
| Glucocorticoid hypersecretion following intracerebroventricular injection of ethylcholine mustard aziridinium ion in rats. | 2001 |
|
| Synthesis and antitumor activity of new amphiphilic alkylglycerolipids substituted with a polar head group, 2-(2-trimethylammonioethoxy)ethyl or a congeneric oligo(ethyleneoxy)ethyl group. | 1989-12 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:54:29 GMT 2025
by
admin
on
Mon Mar 31 19:54:29 GMT 2025
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| Record UNII |
6J5QMU852F
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| Record Status |
Validated (UNII)
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| Record Version |
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25781
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13205-69-1
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DTXSID00157326
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admin on Mon Mar 31 19:54:29 GMT 2025 , Edited by admin on Mon Mar 31 19:54:29 GMT 2025
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6J5QMU852F
Created by
admin on Mon Mar 31 19:54:29 GMT 2025 , Edited by admin on Mon Mar 31 19:54:29 GMT 2025
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PRIMARY |