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Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 14:22:09 UTC 2023
Edited
by admin
on Sat Dec 16 14:22:09 UTC 2023
Protein Type RECEPTOR
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
6J2FX2UG0F
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SYNAPTIC VESICLE GLYCOPROTEIN 2A
Common Name English
SV2A
Common Name English
Code System Code Type Description
FDA UNII
6J2FX2UG0F
Created by admin on Sat Dec 16 14:22:09 UTC 2023 , Edited by admin on Sat Dec 16 14:22:09 UTC 2023
PRIMARY
UNIPROT
Q7L0J3
Created by admin on Sat Dec 16 14:22:09 UTC 2023 , Edited by admin on Sat Dec 16 14:22:09 UTC 2023
PRIMARY
Glycosylation Link Type Site
N 1_498
N 1_548
N 1_573
Related Record Type Details
MODULATOR->TARGET
Positive modulator of SV2A
LIGAND->TARGET
LIGAND->TARGET
RADIOLIGAND->TARGET
he measured in vivo Kd value of 11C-UCB-J in this study (3.4 +/- 0.2 nM) is in good agreement with the reported in vitro inhibition constant (Ki) value of 6.3 nM for human SV2A (11). Furthermore, the estimated regional density (Bmax) for neuronal SV2A protein in this study is 125350 nM, which also is in close agreement with the reported regional Bmax values in the human brain measured in vitro. In preparation for the use of 11C-UCB-J in humans, we performed whole-body distribution studies in rhesus monkeys to calculate organ radiation dosimetry. The organs receiving the largest dose were the liver for males (0.0199 mGy/MBq or 0.0735 rad/mCi) and the brain for females (0.0181 mGy/MBq or 0.0671 rad/mCi). The estimated effective dose equivalent (EDE) value of approximately 4.5 .MU.Sv/MBq for 11C-UCB-J EDE is in the lower range of EDE values (3.317.4 .MU.Sv/MBq) reported in a recent review of organ dosimetry for 11C-labeled radiotracer. Therefore, the maximum EDE from a single 740 MBq (20 mCi) administration of 11C-UCB-J is equivalent to 3.4 mSv (0.34 rem). Thus, multiple injections can be performed in healthy subjects per year.
Kd
RADIOLIGAND->TARGET
LIGAND->TARGET
INHIBITOR -> TARGET
IC50
RADIOLIGAND->TARGET
LIGAND->TARGET
RADIOLIGAND->TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL