LANTHANUM

Possibly Marketed Outside US

First approved in 2010

Details

Stereochemistry	ACHIRAL
Molecular Formula	La
Molecular Weight	138.9055
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[La]

InChI

InChIKey=FZLIPJUXYLNCLC-UHFFFAOYSA-N

InChI=1S/La

HIDE SMILES / InChI

Molecular Formula	La
Molecular Weight	138.9055
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/68007811 | http://www.hmdb.ca/metabolites/HMDB0013711 | https://www.ncbi.nlm.nih.gov/pubmed/30999219

LANTHANUM belongs to the rare earth metals being a prototypical element of this group. Its compounds have numerous industrial applications as catalysts, glass additives, electron cathodes, scintillators, and others. Also, it can be used as a feed additive to improve animal health and production.

Approval Year

PubMed

Title	Date	PubMed
Insulin-like growth factor II stimulates calcium influx in competent BALB/c 3T3 cells primed with epidermal growth factor. Characteristics of calcium influx and involvement of GTP-binding protein.	1987 Sep 5	2442157
Zinc allosterically modulates antagonist binding to cloned D1 and D2 dopamine receptors.	1997 May	9109525
The interactions of hexachlorocyclohexane isomers with human gamma-aminobutyric acid(A) receptors expressed in Xenopus oocytes.	1997 Sep	9316872
The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel.	2001 Feb 16	11179201
Inhibition of transiently expressed low- and high-voltage-activated calcium channels by trivalent metal cations.	2002 Jun 1	12163980
Diacylglycerol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving endogenous TRP6 gene products.	2002 May 15	11988098
Calcium-sensing receptor stimulation induces nonselective cation channel activation in breast cancer cells.	2006	17041782
Metabotropic receptor-activated calcium increases and store-operated calcium influx in mouse Müller cells.	2008 Jul	18316702
La3+ binds to BiP/GRP78 and induces unfolded protein response in HepG2 cells.	2008 Nov 25	18773883
Leptin excites proopiomelanocortin neurons via activation of TRPC channels.	2010 Jan 27	20107083
Calcium-sensing receptor modulates extracellular Ca(2+) entry via TRPC-encoded receptor-operated channels in human aortic smooth muscle cells.	2011 Aug	21562303
Heavy metal cations permeate the TRPV6 epithelial cation channel.	2011 Jan	21146870
[Effects of lanthanum on the phosphorylation of cAMP response element binding protein and expression of immediate early genes in the hippocampal CA3 area of rats].	2011 May	21695898
Insulin increases surface expression of TRPC6 channels in podocytes: role of NADPH oxidases and reactive oxygen species.	2012 Feb 1	22031853

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:31:31 UTC 2023` Edited by `admin` on `Fri Dec 15 16:31:31 UTC 2023`
Record UNII	6I3K30563S
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

LANTHANUM

Systematic Name

English

LANTHANUM [VANDF]

Common Name

English

LANTHANUM [MI]

Common Name

English

LA

Code

English

Classification Tree Code System Code

DSLD

1500 (Number of products:26)