SALVINORIN B

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H26O7
Molecular Weight	390.4269
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC(=O)[C@@H]1C[C@H](O)C(=O)[C@H]2[C@@]1(C)CC[C@H]3C(=O)O[C@@H](C[C@]23C)C4=COC=C4

InChI

InChIKey=BLTMVAIOAAGYAR-CEFSSPBYSA-N

InChI=1S/C21H26O7/c1-20-6-4-12-19(25)28-15(11-5-7-27-10-11)9-21(12,2)17(20)16(23)14(22)8-13(20)18(24)26-3/h5,7,10,12-15,17,22H,4,6,8-9H2,1-3H3/t12-,13-,14-,15-,17-,20-,21-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C21H26O7
Molecular Weight	390.4269
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	7 / 7
E/Z Centers	0
Optical Activity	UNSPECIFIED

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Kappa opioid receptor 115 Target ID: CHEMBL237 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25937170	Agonist 2752		11.8 nM [EC50]

PubMed

Title	Date	PubMed
Regulating nociceptive transmission by VGluT2-expressing spinal dorsal horn neurons.	2018-11	30203849
Effects of mesyl salvinorin B alone and in combination with naltrexone on alcohol deprivation effect in male and female mice.	2018-04-23	29496608
Salvinorin A reduces neuropathic nociception in the insular cortex of the rat.	2018-02	28975684
Screening of Hallucinogenic Compounds and Genomic Characterisation of 40 Anatolian Salvia Species.	2017-11	28722248
The analgesic and anti-inflammatory effects of Salvinorin A analogue β-tetrahydropyran Salvinorin B in mice.	2017-07	28158929
Addressing Structural Flexibility at the A-Ring on Salvinorin A: Discovery of a Potent Kappa-Opioid Agonist with Enhanced Metabolic Stability.	2017-05-11	28376298
Role of Ventral Subiculum in Context-Induced Relapse to Alcohol Seeking after Punishment-Imposed Abstinence.	2016-03-16	26985037
Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats.	2016-01	26019014
A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior.	2015-05-20	25937170
Analytical investigation of legal high products containing Salvia divinorum traded in smartshops and internet.	2014-09	25093918
Analysis of the smoke of cigarettes containing Salvia divinorum.	2014-09	24908261

Substance Class	Chemical Created by `admin` on `Wed Apr 02 05:49:05 GMT 2025` Edited by `admin` on `Wed Apr 02 05:49:05 GMT 2025`
Record UNII	6HNB6FRT7X
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

(-)-SALVINORIN B

Preferred Name

English

SALVINORIN B

Common Name

English

METHYL (2R,4AR,6AR,7S,9R,10AS,10BR)-2-(FURAN-3-YL)-6A,10B-DIMETHYL-9-OXIDANYL-4,10-BIS(OXIDANYLIDENE)-2,4A,5,6,7,8,9,10A-OCTAHYDRO-1H-BENZO(F)ISOCHROMENE-7-CARBOXYLATE

Systematic Name

English

DIVINORIN B

Common Name

English

2H-NAPHTHO(2,1-C)PYRAN-7-CARBOXYLIC ACID, 2-(3-FURANYL)DODECAHYDRO-9-HYDROXY-6A,10B-DIMETHYL-4,10-DIOXO-, METHYL ESTER, (2S,4AR,6AR,7R,9S,10AS,10BR)-

Systematic Name

English

SANGUINARINE (RG)

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID50465988

Created by admin on Wed Apr 02 05:49:05 GMT 2025 , Edited by admin on Wed Apr 02 05:49:05 GMT 2025

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FDA UNII

6HNB6FRT7X

Created by admin on Wed Apr 02 05:49:05 GMT 2025 , Edited by admin on Wed Apr 02 05:49:05 GMT 2025

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PUBCHEM

11440685

Created by admin on Wed Apr 02 05:49:05 GMT 2025 , Edited by admin on Wed Apr 02 05:49:05 GMT 2025

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CAS

92545-30-7

Created by admin on Wed Apr 02 05:49:05 GMT 2025 , Edited by admin on Wed Apr 02 05:49:05 GMT 2025

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