Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C24H35NO4.2C4H4O4 |
| Molecular Weight | 633.6833 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 2 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)\C=C\C(O)=O.OC(=O)\C=C\C(O)=O.COC1=C(C)C(C)=C(O)C(C)=C1CN(C)CCOC2=CC(C)=C(O)C=C2C(C)C
InChI
InChIKey=SZSMNSNVWDKMMN-LVEZLNDCSA-N
InChI=1S/C24H35NO4.2C4H4O4/c1-14(2)19-12-21(26)15(3)11-22(19)29-10-9-25(7)13-20-18(6)23(27)16(4)17(5)24(20)28-8;2*5-3(6)1-2-4(7)8/h11-12,14,26-27H,9-10,13H2,1-8H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1+
| Molecular Formula | C24H35NO4 |
| Molecular Weight | 401.539 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C4H4O4 |
| Molecular Weight | 116.0722 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 23:15:22 GMT 2025
by
admin
on
Mon Mar 31 23:15:22 GMT 2025
|
| Record UNII |
6GT28R35SG
|
| Record Status |
Validated (UNII)
|
| Record Version |
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-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Common Name | English | ||
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Preferred Name | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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6GT28R35SG
Created by
admin on Mon Mar 31 23:15:22 GMT 2025 , Edited by admin on Mon Mar 31 23:15:22 GMT 2025
|
PRIMARY | |||
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171277-07-9
Created by
admin on Mon Mar 31 23:15:22 GMT 2025 , Edited by admin on Mon Mar 31 23:15:22 GMT 2025
|
PRIMARY | |||
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JTH 601
Created by
admin on Mon Mar 31 23:15:22 GMT 2025 , Edited by admin on Mon Mar 31 23:15:22 GMT 2025
|
PRIMARY | JTH-601 (10(-9)-3 x 10(-8) M) competitively antagonized phenylephrine-induced contraction in lower urinary tract tissues (prostate, urethra and bladder trigon) in a concentration-dependent manner. The mean pA2 values for JTH-601 were 8.59+/-0.14, 8.74+/-0.09 and 8.77+/-0.11 for prostate, urethra and bladder trigon, respectively. | ||
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119026061
Created by
admin on Mon Mar 31 23:15:22 GMT 2025 , Edited by admin on Mon Mar 31 23:15:22 GMT 2025
|
PRIMARY | |||
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JTH-601
Created by
admin on Mon Mar 31 23:15:22 GMT 2025 , Edited by admin on Mon Mar 31 23:15:22 GMT 2025
|
PRIMARY | A newly synthesized alpha 1-adrenoceptor antagonist, JTH-601 (N-(3-hydroxy-6-methoxy-2,4,5-trimethylbenzyl)-N-methyl-2-(4-hydro xy-2-isopropyl-5-methyl-phenoxy) ethylamine hemifumarate) showed approximately a 10 times higher affinity for the alpha 1L group, a similar affinity for the alpha 1A subtype, but a more than 10 times lower affinity for the alpha 1B and alpha 1D subtypes when compared with prazosin. These results provide a further pharmacological evidence that alpha 1-adrenoceptors with low affinity for prazosin exist in addition to those with high affinity for prazosin, suggesting that JTH-601 may be useful for characterising the alpha 1-adrenoceptor subtypes. |
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |