BROMOCHLOROSALICYLANILIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H9BrClNO2
Molecular Weight	326.573
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC1=C(C=C(Br)C=C1)C(=O)NC2=CC=C(Cl)C=C2

InChI

InChIKey=QBSGXIBYUQJHMJ-UHFFFAOYSA-N

InChI=1S/C13H9BrClNO2/c14-8-1-6-12(17)11(7-8)13(18)16-10-4-2-9(15)3-5-10/h1-7,17H,(H,16,18)

HIDE SMILES / InChI

Molecular Formula	C13H9BrClNO2
Molecular Weight	326.573
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3743047 | https://www.ncbi.nlm.nih.gov/pubmed/5056804
Curator's Comment: Description was created based on several sources, including https://books.google.ru/books?id=2o3sCAAAQBAJ&pg=PA350&lpg=PA350&dq=Multifungin retrieved from Allergic Reactions to Drugs edited by Alain L. de Weck, H. Bundgaard, p.350

Bromochlorosalicylanilide (Multifungin) is a bromsalan antifungal that has been applied topically. It may cause allergic contact dermatitis in some individuals.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Microsporum gypseum 2 Target ID: CHEMBL612945 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3729389	Inhibitor 8297
Trichophyton mentagrophytes 3 Target ID: CHEMBL613162 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3729389	Inhibitor 8297
Trichophyton rubrum 5 Target ID: CHEMBL612649 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3729389	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Mycoses 12 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5056804 https://www.ncbi.nlm.nih.gov/pubmed/13674390	Primary		Approved 8429	Multifungin Approved Use Fungal infections

PubMed

Title	Date	PubMed
Relationship between the structure and antimycobacterial activity of substituted salicylanilides.	2003 Mar	12666254

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Topical

In Vitro Use Guide

The minimum fungistatic concentrations of Bromochlorosalicylanilide (Multifungin) against M. gypseum was 18000 ppm

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:37:06 GMT 2023` Edited by `admin` on `Fri Dec 15 18:37:06 GMT 2023`
Record UNII	6GK715PWMQ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BROMOCHLOROSALICYLANILIDE

Systematic Name

English

NSC-526297

Code

English

CLOBROMSALAN

Common Name

English

SALICYLANILIDE, 5-BROMO-4'-CHLORO-

Systematic Name

English

SALIFUNGEN

Common Name

English

BROMOSALICYLCHLORANILIDE [MI]

Common Name

English

SALIFUNGIN

Common Name

English

Bromochlorosalicylanilide [WHO-DD]

Common Name

English

BROMOSALICYCHLORANILIDINE

Common Name

English

5-BROMOSALICYL-4'-CHLOROANILIDE

Common Name

English

5-BROMO-4'-CHLOROSALICYLANILIDE

Systematic Name

English

Classification Tree Code System Code

WHO-ATC

D01AE01