Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C31H35Cl2N3O2.C4H6O4 |
Molecular Weight | 670.623 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)CCC(O)=O.CN(C[C@@H](CCN1CCC(CC1)(NC(C)=O)C2=CC=CC=C2)C3=CC=C(Cl)C(Cl)=C3)C(=O)C4=CC=CC=C4
InChI
InChIKey=RCPXXEKUUCEFEI-UFTMZEDQSA-N
InChI=1S/C31H35Cl2N3O2.C4H6O4/c1-23(37)34-31(27-11-7-4-8-12-27)16-19-36(20-17-31)18-15-26(25-13-14-28(32)29(33)21-25)22-35(2)30(38)24-9-5-3-6-10-24;5-3(6)1-2-4(7)8/h3-14,21,26H,15-20,22H2,1-2H3,(H,34,37);1-2H2,(H,5,6)(H,7,8)/t26-;/m1./s1
Molecular Formula | C31H35Cl2N3O2 |
Molecular Weight | 552.535 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Molecular Formula | C4H6O4 |
Molecular Weight | 118.088 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Sanofi aventis developed saredutant (also known as SR 48968C) as a tachykinin neurokinin-2 (NK2) receptor antagonist for the treatment of depressive disorders and generalized anxiety disorder. This drug participated in phase III clinical trials in patients with a generalized anxiety disorder and as Combination Treatment for major depressive disorder, however, the drug failed to meet efficacy endpoints. It is known that NK-2 receptor mediates airway obstruction that is why saredutant was studied as a potential treatment of asthma. However, all studies of the drug were discontinued.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
A potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor. | 1992 |
|
Influence of (+/-)-CP-96,345 and SR 48968 on electrical field stimulation of the isolated guinea-pig main bronchus. | 1992 Dec 2 |
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Capsaicin-induced bladder hyperactivity in normal conscious rats. | 1994 Aug |
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Role of tachykinins in castor oil diarrhoea in rats. | 1997 Jun |
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Effect of tachykinin receptor antagonists in experimental neuropathic pain. | 1998 Nov 20 |
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Role of supraspinal tachykinins for volume- and L-dopa-induced bladder activity in normal conscious rats. | 2000 |
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SCH 206272: a potent, orally active tachykinin NK(1), NK(2), and NK(3) receptor antagonist. | 2002 Aug 23 |
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Actions of endothelin and corticotropin releasing factor in the guinea-pig ileum: no evidence for an interaction with capsaicin-sensitive neurons. | 2003 Aug |
|
Behavioral effects of saredutant, a tachykinin NK2 receptor antagonist, in experimental models of mood disorders under basal and stress-related conditions. | 2008 Sep |
|
Contractile responses induced by physalaemin, an analogue of substance P, in the rat esophagus. | 2010 Feb 25 |
|
ACS chemical neuroscience molecule spotlight on Saredutant. | 2010 Oct 20 |
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT00417118
Saredutant 100 mg once daily in the morning for a maximum of 8 weeks
Route of Administration:
Oral
Substance Class |
Chemical
Created
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admin
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Sat Dec 16 03:28:44 UTC 2023
by
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Record UNII |
6FE8PG636R
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Record Status |
Validated (UNII)
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6FE8PG636R
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