Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C24H28N8O2.ClH |
| Molecular Weight | 496.992 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.OC1CCN(CC1)C2=CC=C(NC3=NC(=NC4=C3C(=O)NN=C4)N5CCC(CC#N)CC5)C=C2
InChI
InChIKey=KAYUSRUJDSKRCJ-UHFFFAOYSA-N
InChI=1S/C24H28N8O2.ClH/c25-10-5-16-6-11-32(12-7-16)24-28-20-15-26-30-23(34)21(20)22(29-24)27-17-1-3-18(4-2-17)31-13-8-19(33)9-14-31;/h1-4,15-16,19,33H,5-9,11-14H2,(H,30,34)(H,27,28,29);1H
| Molecular Formula | C24H28N8O2 |
| Molecular Weight | 460.5315 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
67.8 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30919407/ |
20 mg single, oral dose: 20 mg route of administration: Oral experiment type: SINGLE co-administered: |
GUSACITINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
136 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30919407/ |
40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered: |
GUSACITINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
186 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30919407/ |
80 mg single, oral dose: 80 mg route of administration: Oral experiment type: SINGLE co-administered: |
GUSACITINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
82.9 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30919407/ |
20 mg 1 times / day multiple, oral dose: 20 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
GUSACITINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
171 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30919407/ |
40 mg 1 times / day multiple, oral dose: 40 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
GUSACITINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
252 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30919407/ |
80 mg 1 times / day multiple, oral dose: 80 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
GUSACITINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
580 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30919407/ |
20 mg single, oral dose: 20 mg route of administration: Oral experiment type: SINGLE co-administered: |
GUSACITINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
1410 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30919407/ |
40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered: |
GUSACITINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
2120 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30919407/ |
80 mg single, oral dose: 80 mg route of administration: Oral experiment type: SINGLE co-administered: |
GUSACITINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
850 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30919407/ |
20 mg 1 times / day multiple, oral dose: 20 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
GUSACITINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
2097 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30919407/ |
40 mg 1 times / day multiple, oral dose: 40 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
GUSACITINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
3281 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30919407/ |
80 mg 1 times / day multiple, oral dose: 80 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
GUSACITINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
6.62 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30919407/ |
20 mg single, oral dose: 20 mg route of administration: Oral experiment type: SINGLE co-administered: |
GUSACITINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
9.1 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30919407/ |
40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered: |
GUSACITINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
11.2 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30919407/ |
80 mg single, oral dose: 80 mg route of administration: Oral experiment type: SINGLE co-administered: |
GUSACITINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
7.33 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30919407/ |
20 mg 1 times / day multiple, oral dose: 20 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
GUSACITINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
10.7 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30919407/ |
40 mg 1 times / day multiple, oral dose: 40 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
GUSACITINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
14.1 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30919407/ |
80 mg 1 times / day multiple, oral dose: 80 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
GUSACITINIB plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:51:56 GMT 2025
by
admin
on
Mon Mar 31 21:51:56 GMT 2025
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| Record UNII |
6F56P7NL33
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| Record Status |
Validated (UNII)
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| Record Version |
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-
Download
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2228989-14-6
Created by
admin on Mon Mar 31 21:51:56 GMT 2025 , Edited by admin on Mon Mar 31 21:51:56 GMT 2025
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6F56P7NL33
Created by
admin on Mon Mar 31 21:51:56 GMT 2025 , Edited by admin on Mon Mar 31 21:51:56 GMT 2025
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C175081
Created by
admin on Mon Mar 31 21:51:56 GMT 2025 , Edited by admin on Mon Mar 31 21:51:56 GMT 2025
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GH-06
Created by
admin on Mon Mar 31 21:51:56 GMT 2025 , Edited by admin on Mon Mar 31 21:51:56 GMT 2025
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139593390
Created by
admin on Mon Mar 31 21:51:56 GMT 2025 , Edited by admin on Mon Mar 31 21:51:56 GMT 2025
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300000011141
Created by
admin on Mon Mar 31 21:51:56 GMT 2025 , Edited by admin on Mon Mar 31 21:51:56 GMT 2025
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ACTIVE MOIETY |