BENZMALECENE

Details

Stereochemistry	MIXED
Molecular Formula	C20H19Cl2NO3
Molecular Weight	392.276
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(NC(=O)\C=C/C(O)=O)C(CC1=CC=C(Cl)C=C1)C2=CC=C(Cl)C=C2

InChI

InChIKey=NKPCAAMLVDTZOB-KHPPLWFESA-N

InChI=1S/C20H19Cl2NO3/c1-13(23-19(24)10-11-20(25)26)18(15-4-8-17(22)9-5-15)12-14-2-6-16(21)7-3-14/h2-11,13,18H,12H2,1H3,(H,23,24)(H,25,26)/b11-10-

HIDE SMILES / InChI

Molecular Formula	C20H19Cl2NO3
Molecular Weight	392.276
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	1
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13799281

Benzmalecene, an inhibitor of cholesterol biosynthesis, was studied for patients with hypercholesterolemia. Unfortunately, treatment was associated with undesirable side effects that prevented further using this drug in clinical.

Approval Year

PubMed

Title	Date	PubMed

Sample Use Guides

In Vivo Use Guide

Benzmalecene in 0.5-1.0 g/day of the free acid (or sodium salt) was studied in 6 patients for 10 to 53 days.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:55:55 GMT 2023` Edited by `admin` on `Sat Dec 16 16:55:55 GMT 2023`
Record UNII	6ET4K804XA
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BENZMALECENE

Official Name

English

N-(2,3-BIS(P-CHLOROPHENYL)-1-METHYLPROPYL)MALEAMIC ACID (.ALPHA.-FORM)

Common Name

English

benzmalecene [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29703