LEAD NITRATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	2NO3.Pb
Molecular Weight	331.2
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[PbH2++].[O-][N+]([O-])=O.[O-][N+]([O-])=O

InChI

InChIKey=FBGLTMARTMRVMF-UHFFFAOYSA-N

InChI=1S/2NO3.Pb.2H/c2*2-1(3)4;;;/q2*-1;+2;;

HIDE SMILES / InChI

Molecular Formula	NO3
Molecular Weight	62.0049
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Pb
Molecular Weight	207.2
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2987134

There is no information about pharmacological application of lead nitrate but is known, that this is a toxic substance and probably carcinogenic. Lead substitutes a zinc in the enzyme pyrimidine-5′-nucleotidase, the correct function of this enzyme is very important for the metabolism of DNA.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cytosolic 5'-nucleotidase 3A 1 Target ID: Q9H0P0\|\|\|Q9UC42 Gene ID: 51251.0 Gene Symbol: NT5C3A Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/2987134	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Lead nitrate inhibits the induction of CYP1A mRNAs by aromatic amines but not by aryl hydrocarbons in the rat liver.	1996 Sep	8902619
Polycyclic aromatic hydrocarbon/metal mixtures: effect on PAH induction of CYP1A1 in human HEPG2 cells.	2001 Jul	11408366
Lead attenuation of episodic growth hormone secretion in male rats.	2002 Mar-Apr	12022635
Expression of heat shock protein and hemoglobin genes in Chironomus tentans (Diptera, chironomidae) larvae exposed to various environmental pollutants: a potential biomarker of freshwater monitoring.	2006 Nov	16624371
Toxicogenomics of water chemistry influence on chronic lead exposure to the fathead minnow (Pimephales promelas).	2008 May 1	18346799
Potential role of alpha-synuclein and metallothionein in lead-induced inclusion body formation.	2009 Sep	19542206
Lead induces the expression of endoplasmic reticulum chaperones GRP78 and GRP94 in vascular endothelial cells via the JNK-AP-1 pathway.	2010 Apr	20071421
Molecular analysis, developmental function and heavy metal-induced expression of ABCC5 in zebrafish.	2011 Jan	20869459
Involvement of the epidermal growth factor receptor in Pb²+-induced activation of cPLA₂/COX-2 genes and PGE₂ production in vascular smooth muscle cells.	2011 Jan 11	20850495
Hepatic expression of spermatogenic genes and their transiently remarkable downregulations in Wistar-Kyoto rats in response to lead-nitrate administration: strain-difference in the gene expression patterns.	2011 Jun	21628963
Involvement of interleukin-1 in lead nitrate-induced hypercholesterolemia in mice.	2012	22293356
Divalent copper is a potent extracellular blocker for TRPM2 channel.	2012 Jul 27	22750002
Lead induces dysregulation of iron regulatory protein 1 via the extracellular signal-regulated kinase pathway in human vascular endothelial cells.	2012 May 21	22502979
Lead at 2.5 and 5.0 μM induced aberrant MH-II surface expression through increased MII exocytosis and increased autophagosome formation in Raw 267.4 cells.	2013 Apr	23376802
The role of aryl hydrocarbon receptor signaling pathway in cardiotoxicity of acute lead intoxication in vivo and in vitro rat model.	2013 Apr 5	23391631
Induced expression of hepatic N-methyl-D-aspartate receptor 2C subunit gene during liver enlargement induced by lead nitrate, a hepatocellular mitogen.	2013 Feb	23358146
Protective effects of puerarin on experimental chronic lead nephrotoxicity in immature female rats.	2013 Feb	23315276
Exposure to lead in water and cysteine non-oxidative metabolism in Pelophylax ridibundus tissues.	2013 Feb	22525307
Lead-induced neurodegenerative events and abnormal behaviors occur via ORXRergic/GABA(A)Rergic mechanisms in a marine teleost.	2013 Jan 15	23246865
Function of DNA methyltransferase 3a in lead (Pb(2+) )-Induced Cyclooxygenase-2 gene.	2015 Sep	24639330

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

A transgenic cell line G12 containing a single copy of the E. coli gpt gene was developed in the laboratory from Chinese hamster V79 cells. The gpt locus in the G12 cells is more mutable by radiation and oxidative agents compared with the endogenous hprt locus of wild-type V79 cells. It was investigated the mutagenicity of lead nitrate at the gpt locus in G12 cells. Lead nitrate is not significantly mutagenic at any dose. A nick translation assay on cells treated with lead compound and then permeabilized indicated that lead nitrate causes the appearance of nicks in chromosomal DNA. Lead ions in the presence of hydrogen peroxide, but not alone, introduced nicks into supercoiled plasmid DNA in vitro, suggesting that lead ions can partake in a Fenton reaction and thereby damage DNA.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:58:25 GMT 2023` Edited by `admin` on `Fri Dec 15 18:58:25 GMT 2023`
Record UNII	6E5P1699FI
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LEAD NITRATE

Systematic Name

English

LEAD NITRATE [HSDB]

Common Name

English

LEAD NITRATE [MI]

Common Name

English

PLUMBOUS NITRATE

Common Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

48000