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Details

Stereochemistry ACHIRAL
Molecular Formula 2NO3.Pb
Molecular Weight 331.2
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LEAD NITRATE

SMILES

[PbH2++].[O-][N+]([O-])=O.[O-][N+]([O-])=O

InChI

InChIKey=FBGLTMARTMRVMF-UHFFFAOYSA-N
InChI=1S/2NO3.Pb.2H/c2*2-1(3)4;;;/q2*-1;+2;;

HIDE SMILES / InChI

Molecular Formula NO3
Molecular Weight 62.0049
Charge -1
Count
MOL RATIO 2 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Pb
Molecular Weight 207.2
Charge 2
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

There is no information about pharmacological application of lead nitrate but is known, that this is a toxic substance and probably carcinogenic. Lead substitutes a zinc in the enzyme pyrimidine-5′-nucleotidase, the correct function of this enzyme is very important for the metabolism of DNA.

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct

PubMed

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
A transgenic cell line G12 containing a single copy of the E. coli gpt gene was developed in the laboratory from Chinese hamster V79 cells. The gpt locus in the G12 cells is more mutable by radiation and oxidative agents compared with the endogenous hprt locus of wild-type V79 cells. It was investigated the mutagenicity of lead nitrate at the gpt locus in G12 cells. Lead nitrate is not significantly mutagenic at any dose. A nick translation assay on cells treated with lead compound and then permeabilized indicated that lead nitrate causes the appearance of nicks in chromosomal DNA. Lead ions in the presence of hydrogen peroxide, but not alone, introduced nicks into supercoiled plasmid DNA in vitro, suggesting that lead ions can partake in a Fenton reaction and thereby damage DNA.
Substance Class Chemical
Record UNII
6E5P1699FI
Record Status Validated (UNII)
Record Version