Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | 2NO3.Pb |
| Molecular Weight | 331.2 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[PbH2++].[O-][N+]([O-])=O.[O-][N+]([O-])=O
InChI
InChIKey=FBGLTMARTMRVMF-UHFFFAOYSA-N
InChI=1S/2NO3.Pb.2H/c2*2-1(3)4;;;/q2*-1;+2;;
| Molecular Formula | NO3 |
| Molecular Weight | 62.0049 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | Pb |
| Molecular Weight | 207.2 |
| Charge | 2 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
There is no information about pharmacological application of lead nitrate but is known, that this is a toxic substance and probably carcinogenic. Lead substitutes a zinc in the enzyme pyrimidine-5′-nucleotidase, the correct function of this enzyme is very important for the metabolism of DNA.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Effect of acute pretreatment of lead on picrotoxin-induced convulsions in rats. | 1993 May-Jun |
|
| Lead nitrate inhibits the induction of CYP1A mRNAs by aromatic amines but not by aryl hydrocarbons in the rat liver. | 1996 Sep |
|
| Effect of metals on polycyclic aromatic hydrocarbon induction of CYP1A1 and CYP1A2 in human hepatocyte cultures. | 2001 Jan 15 |
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| Polycyclic aromatic hydrocarbon/metal mixtures: effect on PAH induction of CYP1A1 in human HEPG2 cells. | 2001 Jul |
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| The metallothionein-null phenotype is associated with heightened sensitivity to lead toxicity and an inability to form inclusion bodies. | 2002 Mar |
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| Lead attenuation of episodic growth hormone secretion in male rats. | 2002 Mar-Apr |
|
| Lead nitrate-induced development of hypercholesterolemia in rats: sterol-independent gene regulation of hepatic enzymes responsible for cholesterol homeostasis. | 2004 Dec 1 |
|
| Lead-induced cytotoxicity and transcriptional activation of stress genes in human liver carcinoma (HepG2) cells. | 2004 Jan |
|
| Tumor necrosis factor-alpha-independent downregulation of hepatic cholesterol 7alpha-hydroxylase gene in mice treated with lead nitrate. | 2005 Oct |
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| Expression of heat shock protein and hemoglobin genes in Chironomus tentans (Diptera, chironomidae) larvae exposed to various environmental pollutants: a potential biomarker of freshwater monitoring. | 2006 Nov |
|
| Modulation of TCDD-mediated induction of cytochrome P450 1A1 by mercury, lead, and copper in human HepG2 cell line. | 2008 Feb |
|
| Toxicogenomics of water chemistry influence on chronic lead exposure to the fathead minnow (Pimephales promelas). | 2008 May 1 |
|
| Nickel and binary metal mixture responses in Daphnia magna: molecular fingerprints and (sub)organismal effects. | 2009 Apr 2 |
|
| Ferritin expression in rat hepatocytes and Kupffer cells after lead nitrate treatment. | 2009 Feb |
|
| Potential role of alpha-synuclein and metallothionein in lead-induced inclusion body formation. | 2009 Sep |
|
| Lead induces the expression of endoplasmic reticulum chaperones GRP78 and GRP94 in vascular endothelial cells via the JNK-AP-1 pathway. | 2010 Apr |
|
| Skin toxicology of lead species evaluated by their permeability and proteomic profiles: a comparison of organic and inorganic lead. | 2010 Aug 1 |
|
| Opacification of lenses cultured in the presence of Pb. | 2010 Oct 26 |
|
| Molecular analysis, developmental function and heavy metal-induced expression of ABCC5 in zebrafish. | 2011 Jan |
|
| Involvement of the epidermal growth factor receptor in Pb²+-induced activation of cPLA₂/COX-2 genes and PGE₂ production in vascular smooth muscle cells. | 2011 Jan 11 |
|
| Hepatic expression of spermatogenic genes and their transiently remarkable downregulations in Wistar-Kyoto rats in response to lead-nitrate administration: strain-difference in the gene expression patterns. | 2011 Jun |
|
| Divalent lead cations induce cyclooxygenase-2 gene expression by epidermal growth factor receptor/nuclear factor-kappa B signaling in A431carcinoma cells. | 2011 Jun 10 |
|
| A comparative study on the effects of a pesticide (cypermethrin) and two metals (copper, lead) to serum biochemistry of Nile tilapia, Oreochromis niloticus. | 2011 Sep |
|
| Involvement of interleukin-1 in lead nitrate-induced hypercholesterolemia in mice. | 2012 |
|
| The influence of lead on different proteins in gill cells from the freshwater bivalve, Corbicula fluminea, from defense to repair biomarkers. | 2012 Jan |
|
| Divalent copper is a potent extracellular blocker for TRPM2 channel. | 2012 Jul 27 |
|
| Lead induces dysregulation of iron regulatory protein 1 via the extracellular signal-regulated kinase pathway in human vascular endothelial cells. | 2012 May 21 |
|
| Mangiferin, a natural xanthone, protects murine liver in Pb(II) induced hepatic damage and cell death via MAP kinase, NF-κB and mitochondria dependent pathways. | 2013 |
|
| Lead at 2.5 and 5.0 μM induced aberrant MH-II surface expression through increased MII exocytosis and increased autophagosome formation in Raw 267.4 cells. | 2013 Apr |
|
| The role of aryl hydrocarbon receptor signaling pathway in cardiotoxicity of acute lead intoxication in vivo and in vitro rat model. | 2013 Apr 5 |
|
| Induced expression of hepatic N-methyl-D-aspartate receptor 2C subunit gene during liver enlargement induced by lead nitrate, a hepatocellular mitogen. | 2013 Feb |
|
| Protective effects of puerarin on experimental chronic lead nephrotoxicity in immature female rats. | 2013 Feb |
|
| Exposure to lead in water and cysteine non-oxidative metabolism in Pelophylax ridibundus tissues. | 2013 Feb |
|
| Lead-induced neurodegenerative events and abnormal behaviors occur via ORXRergic/GABA(A)Rergic mechanisms in a marine teleost. | 2013 Jan 15 |
|
| Glioprotective effects of Ashwagandha leaf extract against lead induced toxicity. | 2014 |
|
| Puerarin protects against lead-induced cytotoxicity in cultured primary rat proximal tubular cells. | 2014 Oct |
|
| Heme-regulated eIF2α kinase plays a crucial role in protecting erythroid cells against Pb-induced hemolytic stress. | 2015 Mar 16 |
|
| Function of DNA methyltransferase 3a in lead (Pb(2+) )-Induced Cyclooxygenase-2 gene. | 2015 Sep |
|
| Nephrotoxic effects of lead nitrate exposure in diabetic and nondiabetic rats: Involvement of oxidative stress and the protective role of sodium selenite. | 2016 Oct |
Sample Use Guides
A transgenic cell line G12 containing a single copy of the E. coli gpt gene was developed in the laboratory from Chinese hamster V79 cells. The gpt locus in the G12 cells is more mutable by radiation and oxidative agents compared with the endogenous hprt locus of wild-type V79 cells. It was investigated the mutagenicity of lead nitrate at the gpt locus in G12 cells. Lead nitrate is not significantly mutagenic at any dose. A nick translation assay on cells treated with lead compound and then permeabilized indicated that lead nitrate causes the appearance of nicks in chromosomal DNA. Lead ions in the presence of hydrogen peroxide, but not alone, introduced nicks into supercoiled plasmid DNA in vitro, suggesting that lead ions can partake in a Fenton reaction and thereby damage DNA.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 18:58:25 GMT 2023
by
admin
on
Fri Dec 15 18:58:25 GMT 2023
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| Record UNII |
6E5P1699FI
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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EPA PESTICIDE CODE |
48000
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10099-74-8
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37187
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Lead nitrate
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233-245-9
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C017461
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DTXSID2035069
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m6739
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6E5P1699FI
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637
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