U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Nucleic Acid
Created
by admin
on Sat Dec 16 10:45:43 UTC 2023
Edited
by admin
on Sat Dec 16 10:45:43 UTC 2023
Nucleic Acid Type OLIGONUCLEOTIDE
Nucleic Acid Subtype ANTI-SENSE
Sequence Type COMPLETE
Record UNII
6C4TX6T1CO
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ISIS-426115
Common Name English
Code System Code Type Description
FDA UNII
6C4TX6T1CO
Created by admin on Sat Dec 16 10:45:43 UTC 2023 , Edited by admin on Sat Dec 16 10:45:43 UTC 2023
PRIMARY
Sugar Site Range Site Count
Deoxyribose (DNA) 1_6-1_15 10 / 20
2'-O-Methoxyethyl ribose 1_1-1_5;1_16-1_20 10 / 20
Linkage Site Range Site Count
Sodium Phosporothioate 1_2-1_20 19 / 19

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
NUCLEOSIDE SUBSTITUTION [1_6] [1_15] SITE_SPECIFIC C 5-METHYLDEOXYCYTIDINE B200GV71QM
NUCLEOSIDE SUBSTITUTION [1_2] [1_5] SITE_SPECIFIC C 2'-O-(2-METHOXYETHYL)-5-METHYLCYTIDINE AOQ54IZZ6J
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL