U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C18H22N2O2S.ClH
Molecular Weight 366.905
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of OXOMEMAZINE HYDROCHLORIDE

SMILES

Cl.CC(CN(C)C)CN1C2=CC=CC=C2S(=O)(=O)C3=CC=CC=C13

InChI

InChIKey=NPMMOYKGIWLASW-UHFFFAOYSA-N
InChI=1S/C18H22N2O2S.ClH/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)23(21,22)18-11-7-5-9-16(18)20;/h4-11,14H,12-13H2,1-3H3;1H

HIDE SMILES / InChI

Molecular Formula C18H22N2O2S
Molecular Weight 330.444
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Oxomemazine is a histamine H₁-receptor antagonist. Additionally, oxomemazine could be classified as a ligand for M1 receptors. It is used in the symptomatic treatment of non-productive coughs that occur specifically at night.

Approval Year

PubMed

PubMed

TitleDatePubMed
Extractive spectrophotometric methods for the determination of oxomemazine hydrochloride in bulk and pharmaceutical formulations using bromocresol green, bromocresol purple and bromophenol blue.
2005 Apr
Preliminary studies on phenothiazine-mediated reversal of multidrug resistance in mouse lymphoma and COLO 320 cells.
2005 Nov-Dec
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.
2010 Dec

Sample Use Guides

Oxomemazine 0.33 mg/ml syrup. Suitable for adults and children over 40 kg (from the age of 12 years old). 10 ml 4 times per day. For children: The daily dose according to a child’s weight (1ml of syrup per kg per day): · Child between 13-20 kg (between 2-6 years old): 5ml 2-3 times per day. · Child between 20-30 kg (between 6-10 years old): 10 ml 2-3 times per day. · Child between 30-40 kg (between 10-12 years old): 10 ml 3-4 times a day. Repeat if necessary minimum every 4 hours. Due to the sedative effect of oxomemazine it is advisable to take this medication in the evening.
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Dec 16 10:31:45 GMT 2023
Edited
by admin
on Sat Dec 16 10:31:45 GMT 2023
Record UNII
6BOK44G9K6
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
OXOMEMAZINE HYDROCHLORIDE
WHO-DD  
Common Name English
10H-PHENOTHIAZINE-10-PROPANAMINE, N,N,.BETA.-TRIMETHYL-, 5,5-DIOXIDE, MONOHYDROCHLORIDE
Systematic Name English
PHENOTHIAZINE, 10-(3-(DIMETHYLAMINO)-2-METHYLPROPYL)-, 5,5-DIOXIDE, MONOHYDROCHLORIDE
Common Name English
Oxomemazine hydrochloride [WHO-DD]
Common Name English
10H-PHENOTHIAZINE-10-PROPANAMINE, N,N,.BETA.-TRIMETHYL-, 5,5-DIOXIDE, HYDROCHLORIDE (1:1)
Systematic Name English
Code System Code Type Description
CAS
13718-11-1
Created by admin on Sat Dec 16 10:31:45 GMT 2023 , Edited by admin on Sat Dec 16 10:31:45 GMT 2023
NON-SPECIFIC STOICHIOMETRY
CAS
4784-40-1
Created by admin on Sat Dec 16 10:31:45 GMT 2023 , Edited by admin on Sat Dec 16 10:31:45 GMT 2023
PRIMARY
EVMPD
SUB21934
Created by admin on Sat Dec 16 10:31:45 GMT 2023 , Edited by admin on Sat Dec 16 10:31:45 GMT 2023
PRIMARY
SMS_ID
100000085209
Created by admin on Sat Dec 16 10:31:45 GMT 2023 , Edited by admin on Sat Dec 16 10:31:45 GMT 2023
PRIMARY
PUBCHEM
3083870
Created by admin on Sat Dec 16 10:31:45 GMT 2023 , Edited by admin on Sat Dec 16 10:31:45 GMT 2023
PRIMARY
FDA UNII
6BOK44G9K6
Created by admin on Sat Dec 16 10:31:45 GMT 2023 , Edited by admin on Sat Dec 16 10:31:45 GMT 2023
PRIMARY
EPA CompTox
DTXSID2048612
Created by admin on Sat Dec 16 10:31:45 GMT 2023 , Edited by admin on Sat Dec 16 10:31:45 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
ENANTIOMER -> RACEMATE
ENANTIOMER -> RACEMATE
Related Record Type Details
ACTIVE MOIETY