PYRROBUTAMINE PHOSPHATE

US Previously Marketed

First approved in 1952

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H22ClN.2H3O4P
Molecular Weight	507.839
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OP(O)(O)=O.OP(O)(O)=O.ClC1=CC=C(CC(=CCN2CCCC2)C3=CC=CC=C3)C=C1

InChI

InChIKey=UAAAHOLLLRWGGL-UHFFFAOYSA-N

InChI=1S/C20H22ClN.2H3O4P/c21-20-10-8-17(9-11-20)16-19(18-6-2-1-3-7-18)12-15-22-13-4-5-14-22;2*1-5(2,3)4/h1-3,6-12H,4-5,13-16H2;2*(H3,1,2,3,4)

HIDE SMILES / InChI

Molecular Formula	C20H22ClN
Molecular Weight	311.848
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Molecular Formula	H3O4P
Molecular Weight	97.9952
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugfuture.com/chemdata/pyrrobutamine.html | https://www.ncbi.nlm.nih.gov/pubmed/13114796

PYRROBUTAMINE is a potent H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate the inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Allergy 44 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14949084	Palliative		Approved 8429	Pyronil Approved Use Antihistaminic

Sourcing

Vendor/Aggregator	ID	URL
Alfa Chemistry	ACM28296642
Compound Cloud	5284614
Norris Pharm	NSZB-A030895
Toronto Research Chemicals	P997800
ZINC	ZINC000004474657	http://zinc15.docking.org/substances/ZINC000004474657
ZINC	ZINC000015848271	http://zinc15.docking.org/substances/ZINC000015848271
eMolecules	45955538

PubMed

Title	Date	PubMed
Antihistaminic action of pyronil.	1952 Jul	14949084
Chemical and pharmacological characteristics of the antihistaminic compound, pyrrobutamine.	1953 Nov-Dec	13114796

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:19:26 GMT 2023` Edited by `admin` on `Fri Dec 15 15:19:26 GMT 2023`
Record UNII	6B6107K1Q6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PYRROBUTAMINE PHOSPHATE

Common Name

English

PYRROBUTAMINE DIPHOSPHATE [MI]

Common Name

English

Pyrrobutamine phosphate [WHO-DD]

Common Name

English

PYRROBUTAMINE DIPHOSPHATE

Common Name

English

PYRROLIDINE, 1-(4-(4-CHLOROPHENYL)-3-PHENYL-2-BUTENYL)-, PHOSPHATE (1:2)

Systematic Name

English

1-(.GAMMA.-(P-CHLOROBENZYL)CINNAMYL)PYRROLIDINE PHOSPHATE (1:2)

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578