N-Desmethyltamoxifen hydrochloride

Details

Stereochemistry	ACHIRAL
Molecular Formula	C25H27NO.ClH
Molecular Weight	393.949
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure of N-Desmethyltamoxifen hydrochloride

Structure Search

SMILES

Cl.CC\C(=C(/C1=CC=CC=C1)C2=CC=C(OCCNC)C=C2)C3=CC=CC=C3

InChI

InChIKey=GMLHJWZEYLTNJW-BJFQDICYSA-N

InChI=1S/C25H27NO.ClH/c1-3-24(20-10-6-4-7-11-20)25(21-12-8-5-9-13-21)22-14-16-23(17-15-22)27-19-18-26-2;/h4-17,26H,3,18-19H2,1-2H3;1H/b25-24-;

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C25H27NO
Molecular Weight	357.488
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells.	2009-03-01	19244106
Association of tamoxifen (TAM) and TAM metabolite concentrations with self-reported side effects of TAM in women with breast cancer.	2004-05	15039600
Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine.	2003-12-03	14652237
Reversible and irreversible inhibition of CYP3A enzymes by tamoxifen and metabolites.	2002-10	12419016
Peroxidase activation of tamoxifen and toremifene resulting in DNA damage and covalently bound protein adducts.	1995-03	7697811

Substance Class	Chemical Created by `admin` on `Wed Apr 02 17:30:22 GMT 2025` Edited by `admin` on `Wed Apr 02 17:30:22 GMT 2025`
Record UNII	6AP7YK59KS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

N-Desmethyltamoxifen hydrochloride

Common Name

English

Ethanamine, 2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N-methyl-, hydrochloride, (Z)-

Preferred Name

English

Ethylamine, 2-[p-(1,2-diphenyl-1-butenyl)phenoxy]-N-methyl-, hydrochloride, (Z)-

Systematic Name

English

Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N-methyl-, hydrochloride (1:1)

Systematic Name

English

Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-butenyl]phenoxy]-N-methyl-, hydrochloride

Systematic Name

English

Code System Code Type Description

PUBCHEM

24200424

Created by admin on Wed Apr 02 17:30:22 GMT 2025 , Edited by admin on Wed Apr 02 17:30:22 GMT 2025

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FDA UNII

6AP7YK59KS

Created by admin on Wed Apr 02 17:30:22 GMT 2025 , Edited by admin on Wed Apr 02 17:30:22 GMT 2025

PRIMARY

CAS

15917-65-4

Created by admin on Wed Apr 02 17:30:22 GMT 2025 , Edited by admin on Wed Apr 02 17:30:22 GMT 2025

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