U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C37H48N4O5
Molecular Weight 628.8008
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LOPINAVIR, (2R,4R) DIASTEREOMER-

SMILES

CC(C)[C@H](N1CCCNC1=O)C(=O)N[C@@H](C[C@@H](O)[C@H](CC2=CC=CC=C2)NC(=O)COC3=C(C)C=CC=C3C)CC4=CC=CC=C4

InChI

InChIKey=KJHKTHWMRKYKJE-WRHCQWCJSA-N
InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31+,32-,34+/m1/s1

HIDE SMILES / InChI

Molecular Formula C37H48N4O5
Molecular Weight 628.8008
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

There is no information in the scientific papers related to the biological and pharmacological properties of the diastereomer of lopinavir, LOPINAVIR, (2R,4R)-diastereomer.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:15:41 GMT 2023
Edited
by admin
on Fri Dec 15 16:15:41 GMT 2023
Record UNII
6A96D34YW9
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LOPINAVIR, (2R,4R) DIASTEREOMER-
Common Name English
(S)-N-((2R,4R,5S)-5-(2-(2,6-DIMETHYLPHENOXY)ACETAMIDO)-4-HYDROXY-1,6-DIPHENYLHEXAN-2-YL)-3-METHYL-2-(2-OXOTETRAHYDROPYRIMIDIN-1(2H)-YL)BUTANAMIDE
Systematic Name English
LOPINAVIR (2R,4R) DIASTEREOMER
Common Name English
LOPINAVIR IMPURITY, LOPINAVIR (2R,4R) DIASTEREOMER-
USP  
Common Name English
N-((2R,4R,5S)-5-(2-(2,6-DIMETHYLPHENOXY)ACETAMIDO)-4-HYDROXY-1,6-DIPHENYLHEXAN-2-YL)-3-METHYL-2-(2-OXOTETRAHYDROPYRIMIDIN-1(2H)-YL)BUTANAMIDE, (S)-
Common Name English
LOPINAVIR IMPURITY M [EP IMPURITY]
Common Name English
(2S)-N-((1R,3R,4S)-1-BENZYL-4-((2-(2,6-DIMETHYLPHENOXY)ACETYL)AMINO)-3-HYDROXY-5-PHENYLPENTYL)-3-METHYL-2-(2-OXOTETRAHYDROPYRIMIDIN-1(2H)-YL)BUTANAMIDE
Systematic Name English
LOPINAVIR IMPURITY, LOPINAVIR (2R,4R) DIASTEREOMER- [USP IMPURITY]
Common Name English
LOPINAVIR, (2R,4R)-
Common Name English
Code System Code Type Description
FDA UNII
6A96D34YW9
Created by admin on Fri Dec 15 16:15:41 GMT 2023 , Edited by admin on Fri Dec 15 16:15:41 GMT 2023
PRIMARY
PUBCHEM
76968402
Created by admin on Fri Dec 15 16:15:41 GMT 2023 , Edited by admin on Fri Dec 15 16:15:41 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP