TETRABENAZINE, (+)-

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C19H27NO3
Molecular Weight	317.4226
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@]12CC(=O)[C@H](CC(C)C)CN1CCC3=CC(OC)=C(OC)C=C23

InChI

InChIKey=MKJIEFSOBYUXJB-GDBMZVCRSA-N

InChI=1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3/t14-,16-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C19H27NO3
Molecular Weight	317.4226
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Synaptic vesicular amine transporter 57 Target ID: Q05940 Gene ID: 6571.0 Gene Symbol: SLC18A2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/21396745	Inhibitor 8297		36400.0 nM [Ki]

PubMed

Title	Date	PubMed
Tetrabenazine in the treatment of Huntington's disease.	2007	19381278
ELBARA II, an L-band radiometer system for soil moisture research.	2010	22315556
Calcium signaling and neurodegeneration.	2010 Apr	22649630
Tetrabenazine, a monoamine-depleting drug used in the treatment of hyperkinetic movement disorders.	2010 Aug	20869622

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:54:11 GMT 2023` Edited by `admin` on `Sat Dec 16 08:54:11 GMT 2023`
Record UNII	69ENL3U6BF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TETRABENAZINE, (+)-

Common Name

English

(+)-TBZ

Common Name

English

TETRABENAZINE R,R-FORM [MI]

Common Name

English

(+)-TETRABENAZINE

Common Name

English

(3R,11BR)-TBZ

Common Name

English

2H-BENZO(A)QUINOLIZIN-2-ONE, 1,3,4,6,7,11B-HEXAHYDRO-9,10-DIMETHOXY-3-(2-METHYLPROPYL)-, (3R,11BR)-

Systematic Name

English

(3R,11BR)-1,3,4,6,7,11B-HEXAHYDRO-9,10-DIMETHOXY-3-(2-METHYLPROPYL)-2H-BENZO(A)QUINOLIZIN-2-ONE

Systematic Name

English

(3R,11BR)-TETRABENAZINE

Common Name

English

Code System Code Type Description

MERCK INDEX

m10596