Stereochemistry | ACHIRAL |
Molecular Formula | 2Cl.Ni |
Molecular Weight | 129.599 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Cl-].[Cl-].[Ni++]
InChI
InChIKey=QMMRZOWCJAIUJA-UHFFFAOYSA-L
InChI=1S/2ClH.Ni/h2*1H;/q;;+2/p-2
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
MOL RATIO
2 MOL RATIO (average) |
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | Ni |
Molecular Weight | 58.6934 |
Charge | 2 |
Count |
MOL RATIO
1 MOL RATIO (average) |
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Nickel(II) chloride (NiCl2), a water soluble salt of Nickel, is a toxic and carcinogenic environmental and occupational pollutant, which has been shown to be carcinogenic to the lungs and nasal passages, in cases of long-term inhalation exposure. It was approved that NiCl2 was a potential genotoxicity caused indirect DNA damage by the production of ROS. In addition was conducted studies to evaluate the precise mechanism of Ni toxicology. And it was shown, thet NiCl2 induced and caused cell cycle G2/M phase arrest via p53-dependent pathway and generated inflammatory response by NF-κB pathway activation.
CNS Activity
Originator
Approval Year
PubMed
Patents
Sample Use Guides
Less than 0.1 mg Ni/day (<0.001 mg Ni/kg/day for a 70 kg adult).
Route of Administration:
Oral
The effect of 44 different metal salts on the activity of the reverse transcriptase
(RT) of the human immunodeficiency virus was investigated in vitro. For each metal compound, at least two concentrations were tested (10^-4 M and 10^-5 M). At 100 uM and 10 uM Ni2+ inhibited the RT activity on 5% and 11% of the control, respectively.