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Details

Stereochemistry ACHIRAL
Molecular Formula 2Cl.Ni
Molecular Weight 129.599
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NICKEL CHLORIDE

SMILES

[Cl-].[Cl-].[Ni++]

InChI

InChIKey=QMMRZOWCJAIUJA-UHFFFAOYSA-L
InChI=1S/2ClH.Ni/h2*1H;/q;;+2/p-2

HIDE SMILES / InChI
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula Ni
Molecular Weight 58.6934
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/8187719

Nickel(II) chloride (NiCl2), a water soluble salt of Nickel, is a toxic and carcinogenic environmental and occupational pollutant, which has been shown to be carcinogenic to the lungs and nasal passages, in cases of long-term inhalation exposure. It was approved that NiCl2 was a potential genotoxicity caused indirect DNA damage by the production of ROS. In addition was conducted studies to evaluate the precise mechanism of Ni toxicology. And it was shown, thet NiCl2 induced and caused cell cycle G2/M phase arrest via p53-dependent pathway and generated inflammatory response by NF-κB pathway activation.

CNS Activity

Originator

Cronstedt, A.F.
19
Curator's Comment: Nickel was discovered by Axel Fredrik Cronstedt at 1751 in Sweden.

Approval Year

1994
149
Targets

Targets

Primary TargetPharmacologyConditionPotency
Activator
1430
Blocker
537
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
ECZEMOL

Approved Use

Eczemol® is indicated for the treatment of moderate to severe eczema and atopic dermatitis. It has been found to work well with a variety of combination therapies.
PubMed

PubMed

TitleDatePubMed
NAS-benzidine reaction of blood cells-new simple peroxidase staining method using nickel-ammonium sulfate.
1951 Aug
THE EFFECT OF PHYSICAL FORM OF IMPLANT ON NICKEL SULPHIDE TUMOURIGENESIS IN THE RAT.
1963
EFFECTS OF METHANDROSTENOLONE ON MUSCLE CARCINOGENESIS INDUCED IN RATS BY NICKEL SULPHIDE.
1963 Dec
Nickel concentration of blood and urine after oral administration.
1981 Mar-Apr
Carcinogenicity of nickel(II)hydroxides and nickel(II)sulfate in Wistar rats and its relation to the in vitro dissolution rates.
1983
Nickel oxide: potential carcinogenicity--a review and further evidence.
1984
Occupational asthma from nickel sensitivity: II. Factors influencing the interaction of Ni2+, HSA, and serum antibodies with nickel related specificity.
1984 Feb
Pulmonary deposition and clearance of a nickel oxide aerosol by inhalation.
1985 Feb
Carcinogenesis bioassays of nickel oxides and nickel-copper oxides by intramuscular administration to Fischer-344 rats.
1990 Oct
Metals and trace elements in plasma and cerebrospinal fluid in normal aging and Alzheimer's disease.
1991
Risk assessment of nickel carcinogenicity and occupational lung cancer.
1994 Jan
Deliberations and evaluations of the approaches, endpoints and paradigms for dietary recommendations of the other trace elements.
1996 Sep
How should dietary guidance be given for mineral elements with beneficial actions or suspected of being essential?
1996 Sep
Daily intake of essential minerals and metallic micropollutants from foods in France.
1998 Jun 30
Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study.
1999 May
Molecular mechanisms of nickel carcinogenesis.
2002 Feb 28
Effect of nickel and iron co-exposure on human lung cells.
2004 Apr 15
Molecular biology of nickel carcinogenesis: identification of differentially expressed genes in morphologically transformed C3H10T1/2 Cl 8 mouse embryo fibroblast cell lines induced by specific insoluble nickel compounds.
2004 Jan
Highly selective biaryl cross-coupling reactions between aryl halides and aryl Grignard reagents: a new catalyst combination of N-heterocyclic carbenes and iron, cobalt, and nickel fluorides.
2009 Aug 26
Nickel ion inhibits nuclear factor-kappa B activity in human oral squamous cell carcinoma.
2013
GADD45α induction by nickel negatively regulates JNKs/p38 activation via promoting PP2Cα expression.
2013
L-tyrosinatonickel(II) complex: synthesis and structural, spectroscopic, magnetic, and biological properties of 2{[Ni(L-Tyr)2(bpy)]}·3H2O·CH3OH.
2013 Apr 15
Crucial role of Toll-like receptors in the zinc/nickel-induced inflammatory response in vascular endothelial cells.
2013 Dec 15
Differentiation of skin sensitizers from irritant chemicals by interleukin-1α and macrophage inflammatory protein-2 in murine keratinocytes.
2013 Jan 10
Transition metal sensing by Toll-like receptor-4: next to nickel, cobalt and palladium are potent human dendritic cell stimulators.
2013 Jun
p53 activation by Ni(II) is a HIF-1α independent response causing caspases 9/3-mediated apoptosis in human lung cells.
2013 Jun 15
Differential gene expression profile of the calanoid copepod, Pseudodiaptomus annandalei, in response to nickel exposure.
2013 Mar
Dietary nickel chloride restrains the development of small intestine in broilers.
2013 Nov
Anti-apoptotic proteins and catalase-dependent apoptosis resistance in nickel chloride-transformed human lung epithelial cells.
2013 Sep
Disturbance of aerobic metabolism accompanies neurobehavioral changes induced by nickel in mice.
2013 Sep
Cobalt and nickel stabilize stem cell transcription factor OCT4 through modulating its sumoylation and ubiquitination.
2014
Nickel-induced cell death and survival pathways in cultured renal proximal tubule cells: roles of reactive oxygen species, ceramide and ABCB1.
2014 Apr
Nickel induces interleukin-1β secretion via the NLRP3-ASC-caspase-1 pathway.
2014 Apr
NiCl2-down-regulated antioxidant enzyme mRNA expression causes oxidative damage in the broiler(')s kidney.
2014 Dec
MiRNA-210 modulates a nickel-induced cellular energy metabolism shift by repressing the iron-sulfur cluster assembly proteins ISCU1/2 in Neuro-2a cells.
2014 Feb 27
Dietary nickel chloride induces oxidative stress, apoptosis and alters Bax/Bcl-2 and caspase-3 mRNA expression in the cecal tonsil of broilers.
2014 Jan
Genotoxic changes to rodent cells exposed in vitro to tungsten, nickel, cobalt and iron.
2014 Mar 10
Whole adult organism transcriptional profiling of acute metal exposures in male zebrafish.
2014 Mar 10
A critical role for thymic stromal lymphopoietin in nickel-induced allergy in mice.
2014 May 1
Detoxification of rats subjected to nickel chloride by a biomaterial-based carbonated orthophosphate.
2014 Sep
The effect of divalent metal cations on zinc uptake by mouse Zrt/Irt-like protein 1 (ZIP1).
2014 Sep 15
Novel Flower-like Nickel Sulfide as an Efficient Electrocatalyst for Non-aqueous Lithium-Air Batteries.
2015 Dec 14
Impact of cadmium, cobalt and nickel on sequence-specific DNA binding of p63 and p73 in vitro and in cells.
2015 Jan 2
A not cytotoxic nickel concentration alters the expression of neuronal differentiation markers in NT2 cells.
2015 Mar
Substitution effects of a carbonated hydroxyapatite biomaterial against intoxication chloride nickel-exposed rats.
2015 Mar
Innate stimulatory capacity of high molecular weight transition metals Au (gold) and Hg (mercury).
2015 Mar
Chemical allergens stimulate human epidermal keratinocytes to produce lymphangiogenic vascular endothelial growth factor.
2015 Mar 1
Differential Toxicities of Nickel Salts to the Nematode Caenorhabditis elegans.
2016 Aug
Involvement of L-type Ca²⁺ channel and toll-like receptor-4 in nickel-induced interleukin-8 gene expression.
2016 Jan
The regulatory role of nickel on H3K27 demethylase JMJD3 in kidney cancer cells.
2016 Jul
Patents

Patents

04297499
21
04316851
19
04366087
22
04398049
19
04661617
19
04818430
19
04847288
19
05149847
19
05166380
19
06129902
19
06258483
19
06284215
19
06432580
19
06444363
19
06489487
19
06734201
19
06812240
19
06852712
19
06989395
19
07307165
19
07615549
19
07618978
26
07645789
22
07674741
19
07772247
19
07981903
23
07982044
19
07985863
19
08022235
19
08093264
19
08536179
23
08623905
21
08636967
19
08637509
19
20110176978
19
20130078167
19
CA2129086C
19
US20090298783
19
US2772947
19
US3081149
19
US3836634
19
US3854936
19
US3914124
19
US4160745
19
US7364717
19
WO2014015063A2
19

Sample Use Guides

In Vivo Use Guide
Less than 0.1 mg Ni/day (<0.001 mg Ni/kg/day for a 70 kg adult).
Route of Administration: Oral
In Vitro Use Guide
The effect of 44 different metal salts on the activity of the reverse transcriptase (RT) of the human immunodeficiency virus was investigated in vitro. For each metal compound, at least two concentrations were tested (10^-4 M and 10^-5 M). At 100 uM and 10 uM Ni2+ inhibited the RT activity on 5% and 11% of the control, respectively.
Substance Class Chemical
Created
by admin
on Sat Dec 16 00:32:27 GMT 2023
Edited
by admin
on Sat Dec 16 00:32:27 GMT 2023
Record UNII
696BNE976J
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NICKEL CHLORIDE
HSDB   MI  
Systematic Name English
NICKELOUS CHLORIDE
Common Name English
NICKEL DICHLORIDE
Systematic Name English
NICKEL(2+) CHLORIDE
Systematic Name English
NICKEL CHLORIDE [MI]
Common Name English
NICKEL CHLORIDE [HSDB]
Common Name English
NICKEL(II) CHLORIDE
Systematic Name English
NSC-254532
Code English
Classification Tree Code System Code
NCI_THESAURUS C44407
Created by admin on Sat Dec 16 00:32:27 GMT 2023 , Edited by admin on Sat Dec 16 00:32:27 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C45868
Created by admin on Sat Dec 16 00:32:27 GMT 2023 , Edited by admin on Sat Dec 16 00:32:27 GMT 2023
PRIMARY
EPA CompTox
DTXSID7040316
Created by admin on Sat Dec 16 00:32:27 GMT 2023 , Edited by admin on Sat Dec 16 00:32:27 GMT 2023
PRIMARY
ECHA (EC/EINECS)
231-743-0
Created by admin on Sat Dec 16 00:32:27 GMT 2023 , Edited by admin on Sat Dec 16 00:32:27 GMT 2023
PRIMARY
MERCK INDEX
m7860
Created by admin on Sat Dec 16 00:32:27 GMT 2023 , Edited by admin on Sat Dec 16 00:32:27 GMT 2023
PRIMARY Merck Index
WIKIPEDIA
NICKEL(II) CHLORIDE
Created by admin on Sat Dec 16 00:32:27 GMT 2023 , Edited by admin on Sat Dec 16 00:32:27 GMT 2023
PRIMARY
NSC
254532
Created by admin on Sat Dec 16 00:32:27 GMT 2023 , Edited by admin on Sat Dec 16 00:32:27 GMT 2023
PRIMARY
CHEBI
34887
Created by admin on Sat Dec 16 00:32:27 GMT 2023 , Edited by admin on Sat Dec 16 00:32:27 GMT 2023
PRIMARY
CAS
7718-54-9
Created by admin on Sat Dec 16 00:32:27 GMT 2023 , Edited by admin on Sat Dec 16 00:32:27 GMT 2023
PRIMARY
PUBCHEM
24385
Created by admin on Sat Dec 16 00:32:27 GMT 2023 , Edited by admin on Sat Dec 16 00:32:27 GMT 2023
PRIMARY
HSDB
860
Created by admin on Sat Dec 16 00:32:27 GMT 2023 , Edited by admin on Sat Dec 16 00:32:27 GMT 2023
PRIMARY
MESH
C022838
Created by admin on Sat Dec 16 00:32:27 GMT 2023 , Edited by admin on Sat Dec 16 00:32:27 GMT 2023
PRIMARY
FDA UNII
696BNE976J
Created by admin on Sat Dec 16 00:32:27 GMT 2023 , Edited by admin on Sat Dec 16 00:32:27 GMT 2023
PRIMARY
Related Record Type Details
Structure of NICKEL CHLORIDE HEXAHYDRATE
SOLVATE->ANHYDROUS
NIH
NCATS
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