U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula 2Cl.Ni
Molecular Weight 129.599
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NICKEL CHLORIDE

SMILES

[Cl-].[Cl-].[Ni++]

InChI

InChIKey=QMMRZOWCJAIUJA-UHFFFAOYSA-L
InChI=1S/2ClH.Ni/h2*1H;/q;;+2/p-2

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
MOL RATIO 2 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Ni
Molecular Weight 58.6934
Charge 2
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Nickel(II) chloride (NiCl2), a water soluble salt of Nickel, is a toxic and carcinogenic environmental and occupational pollutant, which has been shown to be carcinogenic to the lungs and nasal passages, in cases of long-term inhalation exposure. It was approved that NiCl2 was a potential genotoxicity caused indirect DNA damage by the production of ROS. In addition was conducted studies to evaluate the precise mechanism of Ni toxicology. And it was shown, thet NiCl2 induced and caused cell cycle G2/M phase arrest via p53-dependent pathway and generated inflammatory response by NF-κB pathway activation.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
ECZEMOL

PubMed

Sample Use Guides

In Vivo Use Guide
Less than 0.1 mg Ni/day (<0.001 mg Ni/kg/day for a 70 kg adult).
Route of Administration: Oral
In Vitro Use Guide
The effect of 44 different metal salts on the activity of the reverse transcriptase (RT) of the human immunodeficiency virus was investigated in vitro. For each metal compound, at least two concentrations were tested (10^-4 M and 10^-5 M). At 100 uM and 10 uM Ni2+ inhibited the RT activity on 5% and 11% of the control, respectively.
Substance Class Chemical
Record UNII
696BNE976J
Record Status Validated (UNII)
Record Version