Delpacibart Etedesiran

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 13:20:40 GMT 2025` Edited by `admin` on `Wed Apr 02 13:20:40 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1
Sequence Origin	humanized
Record UNII	68CPJ8C2ZJ
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Delpacibart Etedesiran

Official Name

English

Immunoglobulin G1 [233-alanine,234-alanine,327-arginine,de-446-lysine], anti-(human type 1 transferrin receptor) (human-Mus musculus clone AV05 ?1-chain), complex with human-Mus musculus clone AV05 ?-chain, 214(219 or 225)-thioether with RNA (Cm-sp-Cm-sp

Preferred Name

English

delpacibart etedesiran [INN]

Common Name

English

Code System Code Type Description

SMS_ID

300000050065

Created by admin on Wed Apr 02 13:20:40 GMT 2025 , Edited by admin on Wed Apr 02 13:20:40 GMT 2025

PRIMARY

CAS

2653183-68-5

Created by admin on Wed Apr 02 13:20:40 GMT 2025 , Edited by admin on Wed Apr 02 13:20:40 GMT 2025

PRIMARY

NCI_THESAURUS

C190371

Created by admin on Wed Apr 02 13:20:40 GMT 2025 , Edited by admin on Wed Apr 02 13:20:40 GMT 2025

PRIMARY

INN

12400

Created by admin on Wed Apr 02 13:20:40 GMT 2025 , Edited by admin on Wed Apr 02 13:20:40 GMT 2025

PRIMARY

FDA UNII

68CPJ8C2ZJ

Created by admin on Wed Apr 02 13:20:40 GMT 2025 , Edited by admin on Wed Apr 02 13:20:40 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_143	2_199
2_219	4_214
2_260	2_320
1_143	1_199
2_366	2_424
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_219	3_214
1_225	2_225
1_228	2_228
1_260	1_320
1_366	1_424

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_296
N	2_296

Related Record Type Details


					68CPJ8C2ZJ

Delpacibart Etedesiran

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL