Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C28H40O8 |
| Molecular Weight | 504.6124 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 8 / 8 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(CO)=C[C@H]2[C@@H]4C(C)(C)[C@]14OC(=O)CCC
InChI
InChIKey=BQJRUJTZSGYBEZ-YVQNUNKESA-N
InChI=1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22-,24-,26-,27-,28-/m1/s1
| Molecular Formula | C28H40O8 |
| Molecular Weight | 504.6124 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 8 / 8 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Ionizing radiation alters myofilament calcium sensitivity in vascular smooth muscle: potential role of protein kinase C. | 2005-09 |
|
| Freezing without surrounding cryomedium preserves the endothelium and its function in human internal mammary arteries. | 2005-08 |
|
| Modulation of Ca(2+)-dependent and Ca(2+)-independent miniature endplate potentials by phorbol ester and adenosine in frog. | 2005-08 |
|
| Protein kinase C delta and epsilon mediate positive inotropy in adult ventricular myocytes. | 2005-05 |
|
| EBV infection induces expression of the transcription factors ATF-2/c-Jun in B lymphocytes but not in B-CLL cells. | 2005-05 |
|
| Signaling of short- and long-term regulation of intestinal epithelial type 1 Na+/H+ exchanger by interferon-gamma. | 2005-05 |
|
| Identification of plasma membrane macro- and microdomains from wavelet analysis of FRET microscopy. | 2005-05 |
|
| Identification of a novel splice variant of human PD-L1 mRNA encoding an isoform-lacking Igv-like domain. | 2005-04 |
|
| Regulation of intracellular Cl- concentration through volume-regulated ClC-3 chloride channels in A10 vascular smooth muscle cells. | 2005-02-25 |
|
| Investigation of PKC isoform-specific translocation and targeting of the current of the late afterhyperpolarizing potential of myenteric AH neurons. | 2005-02 |
|
| Endothelin-1 acts via protein kinase C to block KATP channels in rabbit coronary and pulmonary arterial smooth muscle cells. | 2005-02 |
|
| Stimulation of beta-adrenoceptors inhibits store-operated channel currents via a cAMP-dependent protein kinase mechanism in rabbit portal vein myocytes. | 2005-01-15 |
|
| Anti-Plasmodium activity of ceramide analogs. | 2004-12-10 |
|
| Adenosine inhibits GABAergic and glycinergic transmission in adult rat substantia gelatinosa neurons. | 2004-11 |
|
| Coregulation of glutamate uptake and long-term sensitization in Aplysia. | 2004-10-06 |
|
| Mechanisms of arginine-vasopressin-induced Ca2+ oscillations in beta-cells (HIT-T15): a role for oscillating protein kinase C. | 2004-10 |
|
| Partial bladder outlet obstruction abolishes the receptor- and G protein-dependent increase in calcium sensitivity in rabbit bladder smooth muscle. | 2004-10 |
|
| Evidence for protein kinase involvement in long-term postsynaptic excitation of intrinsic primary afferent neurons in the intestine. | 2004-09-30 |
|
| Mechanisms underlying postjunctional synergism between responses of the vas deferens to noradrenaline and ATP. | 2004-09-13 |
|
| Functional and molecular characterization of a volume-activated chloride channel in rabbit corneal epithelial cells. | 2004-09-01 |
|
| Expression of matrix metalloproteinase-9 in human platelets: regulation of platelet activation in in vitro and in vivo studies. | 2004-09 |
|
| Intestinal Na+-K+-ATPase activity and molecular events downstream of interferon-gamma receptor stimulation. | 2004-08 |
|
| Novel phosphospecific antibodies for monitoring phosphorylation of proteins encoded by the myosin light chain kinase genetic locus. | 2004-07 |
|
| Amyloid beta peptide directly inhibits PKC activation. | 2004-06 |
|
| Noncompetitive metabotropic glutamate5 receptor antagonist (E)-2-methyl-6-styryl-pyridine (SIB1893) depresses glutamate release through inhibition of voltage-dependent Ca2+ entry in rat cerebrocortical nerve terminals (synaptosomes). | 2004-06 |
|
| Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay. | 2004-05-03 |
|
| Cisplatin resistance is associated with deregulation in protein kinase C-delta. | 2004-04-16 |
|
| Heat-shock response is associated with enhanced contractility of vascular smooth muscle in isolated rat aorta. | 2004-04 |
|
| Dopamine acutely decreases type 3 Na(+)/H(+) exchanger activity in renal OK cells through the activation of protein kinases A and C signalling cascades. | 2004-03-19 |
|
| Properties of the basal calcium influx in human red blood cells. | 2004-03-09 |
|
| Abrogation of p21 expression by flavopiridol enhances depsipeptide-mediated apoptosis in malignant pleural mesothelioma cells. | 2004-03-01 |
|
| Protein kinase C regulates functional coupling of beta1-adrenergic receptors to Gi/o-mediated responses in cardiac myocytes. | 2004-02 |
|
| Actin cytoskeleton remodelling via local inhibition of contractility at discrete microdomains. | 2004-01-15 |
|
| Quercetin inhibits the invasion of murine melanoma B16-BL6 cells by decreasing pro-MMP-9 via the PKC pathway. | 2004-01 |
|
| Expression and regulation of interleukin-23 subunits in human peripheral blood mononuclear cells and hematopoietic cell lines in response to various inducers. | 2004 |
|
| N-methyl-D-aspartate receptors enhance mechanical responses and voltage-dependent Ca2+ channels in rat dorsal root ganglia neurons through protein kinase C. | 2004 |
|
| Mechanisms involved in the antiplatelet activity of ketamine in human platelets. | 2003-12-03 |
|
| Comparison of the effects of phorbol dibutyrate and low-frequency stimulation of synaptic inputs on the excitability of myenteric AH neurons. | 2003-12 |
|
| [Changes in the contractility of the NIH3T3 fibroblast induced by the over-expression of CPI-17]. | 2003-11 |
|
| T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. | 2003-11 |
|
| Intracellular mechanism of mitochondrial adenosine triphosphate-sensitive potassium channel activation with isoflurane. | 2003-10 |
|
| Pregabalin and gabapentin reduce release of substance P and CGRP from rat spinal tissues only after inflammation or activation of protein kinase C. | 2003-09 |
|
| Phorbol ester induces CYP2E1 in astrocytes, through a protein kinase C- and tyrosine kinase-dependent mechanism. | 2003-08 |
|
| Prolactin regulates adenylyl cyclase and insulin secretion in rat pancreatic islets. | 2003-06-30 |
|
| Bombesin, lysophosphatidic acid, and epidermal growth factor rapidly stimulate focal adhesion kinase phosphorylation at Ser-910: requirement for ERK activation. | 2003-06-20 |
|
| 15-deoxy-delta12,14 prostaglandin J2 synergizes with phorbol ester to induce proliferation in Swiss 3T3 cells independently of peroxisome proliferator-activated receptor gamma and PGD2 receptors. | 2003-06 |
|
| Heat induced HSP20 phosphorylation without increased cyclic nucleotide levels in swine carotid media. | 2003-04-25 |
|
| Pharmacological characteristics of bombesin receptor mediating hypothermia in the central nervous system of rats. | 2003-04-18 |
|
| Involvement of the antiplatelet activity of magnesium sulfate in suppression of protein kinase C and the Na+/H+ exchanger. | 2003-03-10 |
|
| The forskolin-induced opening of tight junctions in Xenopus gallbladder epithelium is mediated by protein kinase C. | 2003-02 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:52:00 GMT 2025
by
admin
on
Mon Mar 31 19:52:00 GMT 2025
|
| Record UNII |
67MX82CL58
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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17598
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37783
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PHORBOL 12,13-DIBUTYRATE
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37558-16-0
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622507
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67MX82CL58
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DTXSID50958628
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