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Details

Stereochemistry ABSOLUTE
Molecular Formula C25H30F3N3O4
Molecular Weight 493.5186
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of KMD-3241

SMILES

C[C@H](CC1=CC(C(N)=O)=C2N(CCCO)C=CC2=C1)NCCOC3=CC=CC=C3OCC(F)(F)F

InChI

InChIKey=VICSLOHTZDWOFF-QGZVFWFLSA-N
InChI=1S/C25H30F3N3O4/c1-17(30-8-12-34-21-5-2-3-6-22(21)35-16-25(26,27)28)13-18-14-19-7-10-31(9-4-11-32)23(19)20(15-18)24(29)33/h2-3,5-7,10,14-15,17,30,32H,4,8-9,11-13,16H2,1H3,(H2,29,33)/t17-/m1/s1

HIDE SMILES / InChI

Molecular Formula C25H30F3N3O4
Molecular Weight 493.5186
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

KMD-3241 (Dehydro Silodosin) is a silodosin metabolite (also known as an impurity of Silodosin). Silodosin is a selective antagonsit of alpha-1a adrenergic receptor which was developed by Kissei Pharmaceutical and approved by FDA under the name Rapaflo for the treatment of signs and symptoms associated with benign prostatic hyperplasia. The affnities of silodosin metabolites, KMD-3241, KMD-3289 and KMD-3295, for alpha1A-AR subtype receptor were equal to or lower than that of silodosin.

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 10:48:16 GMT 2023
Edited
by admin
on Sat Dec 16 10:48:16 GMT 2023
Record UNII
6787MV7QU0
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
KMD-3241
Common Name English
1H-INDOLE-7-CARBOXAMIDE, 1-(3-HYDROXYPROPYL)-5-((2R)-2-((2-(2-(2,2,2-TRIFLUOROETHOXY)PHENOXY)ETHYL)AMINO)PROPYL)-
Systematic Name English
DEHYDRO SILODOSIN
Common Name English
DEHYDRO SILODOSIN, (-)-
Common Name English
Code System Code Type Description
PUBCHEM
9891871
Created by admin on Sat Dec 16 10:48:16 GMT 2023 , Edited by admin on Sat Dec 16 10:48:16 GMT 2023
PRIMARY
FDA UNII
6787MV7QU0
Created by admin on Sat Dec 16 10:48:16 GMT 2023 , Edited by admin on Sat Dec 16 10:48:16 GMT 2023
PRIMARY
EPA CompTox
DTXSID20432445
Created by admin on Sat Dec 16 10:48:16 GMT 2023 , Edited by admin on Sat Dec 16 10:48:16 GMT 2023
PRIMARY
CAS
175870-21-0
Created by admin on Sat Dec 16 10:48:16 GMT 2023 , Edited by admin on Sat Dec 16 10:48:16 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> METABOLITE
MINOR
FECAL; PLASMA; URINE