| Stereochemistry | ABSOLUTE |
| Molecular Formula | C15H23NO2.ClH |
| Molecular Weight | 285.81 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CC(C)NC[C@@H](O)COC1=CC=CC=C1CC=C
InChI
InChIKey=RRCPAXJDDNWJBI-PFEQFJNWSA-N
InChI=1S/C15H23NO2.ClH/c1-4-7-13-8-5-6-9-15(13)18-11-14(17)10-16-12(2)3;/h4-6,8-9,12,14,16-17H,1,7,10-11H2,2-3H3;1H/t14-;/m1./s1
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C15H23NO2 |
| Molecular Weight | 249.3486 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
(R)-Alprenolol is a less active stereoisomer of antihypertensive beta-blocker alprenolol. Its activity against beta-adrenoreceptor is 100 times lower than the activity of (S)-alprenolol. In a model of ventricular arrhythmias produced by ligation of the left coronary artery, (R)-alprenolol was effective at 15.5 mg/kg, whereas (S)-alprenolol abolished the ventricular arrhythmia by cumulative dose of 7.5 mg/kg.
Originator
Approval Year
PubMed
Patents
Sample Use Guides
In a mode of ventricular arrhythmia (R)-Alprenolol was administered to dogs intravenously at 0.5 - 8.0 mg/kg.
Route of Administration:
Intravenous
Guinea-pig spontaneously beating right atria and tracheal strips were suspended in water-jacketed 10ml tissue baths containing a physiological salt solution. Atria were allowed to equilibrate for 1 hr before any drugs were added. Responses from both tissues were recorded on a Grass polygraph and atrial rates were monitored via 7P4A tachographs. Carbachol (3 × 10 -7 M) was used to induce tone in tracheal strips and added to the bath 15 min prior to determining the relaxing effects of the drug. Selected concentrations of the antagonists were allowed to interact with each tissue for 3, 10, 25, 45, 65, or 120 min before addition of the agonist. All concentrations of antagonists were added in a volume of 0.1 ml.
