CYCLOCREATINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C5H9N3O2
Molecular Weight	143.1439
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)CN1CCNC1=N

InChI

InChIKey=AMHZIUVRYRVYBA-UHFFFAOYSA-N

InChI=1S/C5H9N3O2/c6-5-7-1-2-8(5)3-4(9)10/h1-3H2,(H2,6,7)(H,9,10)

HIDE SMILES / InChI

Molecular Formula	C5H9N3O2
Molecular Weight	143.1439
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22751104 | https://www.ncbi.nlm.nih.gov/pubmed/7850923 | https://www.ncbi.nlm.nih.gov/pubmed/8042860 | https://www.ncbi.nlm.nih.gov/pubmed/9412496

Cyclocreatine is a nearly planar creatine analog. Cyclocreatine is an efficient substrate for creatine kinase, but its phosphorylated form is a poor phosphate donor in comparison with creatine phosphate. It exerts antitumor, antiviral, neuroprotective activity.

CNS Activity

Approval Year

PubMed

Title	Date	PubMed
Cyclocreatine (1-carboxymethyl-2-iminoimidazolidine) inhibits the replication of human herpes viruses.	1994 Apr	8042860
Elevated creatine kinase activity in primary hepatocellular carcinoma.	2005 Mar 5	15748292

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:33:44 GMT 2023` Edited by `admin` on `Fri Dec 15 15:33:44 GMT 2023`
Record UNII	6732XGX1RK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CYCLOCREATINE

Common Name

English

2-IMINO-1-IMIDAZOLIDINEACETIC ACID

Systematic Name

English

NSC-707961

Code

English

AM-285

Code

English

1-CARBOXYMETHYL-2-IMINO-IMIDAZOLIDINE

Systematic Name

English

Classification Tree Code System Code

EU-Orphan Drug

EU/3/16/1676