AGANODINE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H10Cl2N4
Molecular Weight	245.109
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=N)NN1CC2=C(Cl)C=CC(Cl)=C2C1

InChI

InChIKey=DFKHOVYSCCPSHR-UHFFFAOYSA-N

InChI=1S/C9H10Cl2N4/c10-7-1-2-8(11)6-4-15(3-5(6)7)14-9(12)13/h1-2H,3-4H2,(H4,12,13,14)

HIDE SMILES / InChI

Molecular Formula	C9H10Cl2N4
Molecular Weight	245.109
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.researchgate.net/publication/294210987_Potential_mechanisms_involved_in_aganodine-induced_ocular_hypotension

Aganodine, an imidazoline/ alpha-2 receptor agonist, can lower intraocular pressure in the sympathetic neurons of the eye and possibly in the central nervous system.

Approval Year

PubMed

Title	Date	PubMed
A search for presynaptic imidazoline receptors at rabbit and rat noradrenergic neurones in the absence of alpha 2-autoinhibition.	1999-02	10048597
Presynaptic imidazoline receptors and non-adrenoceptor [3H]-idazoxan binding sites in human cardiovascular tissues.	1997-09	9298527

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:25:14 GMT 2025` Edited by `admin` on `Mon Mar 31 18:25:14 GMT 2025`
Record UNII	670P9AQR46
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

aganodine [INN]

Preferred Name

English

AGANODINE

Official Name

English

(4,7-DICHLORO-2-ISOINDOLINYL)GUANIDINE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29709