AGANODINE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H10Cl2N4
Molecular Weight	245.109
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=N)NN1CC2=C(Cl)C=CC(Cl)=C2C1

InChI

InChIKey=DFKHOVYSCCPSHR-UHFFFAOYSA-N

InChI=1S/C9H10Cl2N4/c10-7-1-2-8(11)6-4-15(3-5(6)7)14-9(12)13/h1-2H,3-4H2,(H4,12,13,14)

HIDE SMILES / InChI

Molecular Formula	C9H10Cl2N4
Molecular Weight	245.109
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.researchgate.net/publication/294210987_Potential_mechanisms_involved_in_aganodine-induced_ocular_hypotension

Aganodine, an imidazoline/ alpha-2 receptor agonist, can lower intraocular pressure in the sympathetic neurons of the eye and possibly in the central nervous system.

Approval Year

PubMed

Title	Date	PubMed
Presynaptic imidazoline receptors and non-adrenoceptor [3H]-idazoxan binding sites in human cardiovascular tissues.	1997 Sep	9298527
A search for presynaptic imidazoline receptors at rabbit and rat noradrenergic neurones in the absence of alpha 2-autoinhibition.	1999 Feb	10048597

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:19:51 GMT 2023` Edited by `admin` on `Fri Dec 15 16:19:51 GMT 2023`
Record UNII	670P9AQR46
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AGANODINE

Official Name

English

(4,7-DICHLORO-2-ISOINDOLINYL)GUANIDINE

Systematic Name

English

aganodine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29709