U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Wed Apr 02 02:58:31 GMT 2025
Edited
by admin
on Wed Apr 02 02:58:31 GMT 2025
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
66UL4XJJ3X
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PRIPR
Preferred Name English
PROSTACYCLIN RECEPTOR
Common Name English
PROSTAGLANDIN I2 RECEPTOR
Common Name English
Prostanoid IP receptor
Common Name English
Code System Code Type Description
UNIPROT
P43119
Created by admin on Wed Apr 02 02:58:31 GMT 2025 , Edited by admin on Wed Apr 02 02:58:31 GMT 2025
PRIMARY
FDA UNII
66UL4XJJ3X
Created by admin on Wed Apr 02 02:58:31 GMT 2025 , Edited by admin on Wed Apr 02 02:58:31 GMT 2025
PRIMARY
From To
1_5 1_165
1_92 1_170
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_7
Related Record Type Details
AGONIST -> TARGET
EC50
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
ACT-333679 is 37-fold more potent than selexipag towards prostacyclin IP receptor.
IC50
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
Assumed similar activity as prostaglandin E1
AGONIST -> TARGET
AGONIST -> TARGET
BINDING
IC50
AGONIST -> TARGET

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_383] MECYSTEINE RQ6L463N3B
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL