OZONE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	O3
Molecular Weight	47.9982
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[O-][O+]=O

InChI

InChIKey=CBENFWSGALASAD-UHFFFAOYSA-N

InChI=1S/O3/c1-3-2

HIDE SMILES / InChI

Molecular Formula	O3
Molecular Weight	47.9982
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/30840304 | https://www.ncbi.nlm.nih.gov/pubmed/26687830 | https://clinicaltrials.gov/ct2/show/NCT03660657

Ozone, a gas, is made by three oxygen atoms. It is used for different procedures. Ozone therapy is used to treat a wide range of diseases and seems to be particularly useful in the treatment of many chronic diseases. It acts via the controlled oxidative stress that promotes an up-regulation of the antioxidant system and a modulation of the immune system. Ozone therapy doesn’t have any side effect and was useful in fibromyalgia management, where the employed therapies are very often ineffective. Ozone therapy is also going to be studied in phase III clinical trials to standard management of patients with advanced ischemic heart disease. Besides, ozone therapy was studying for the treatment of chronic hepatitis B.

Approval Year

PubMed

Title	Date	PubMed
NAD(P)H quinone oxidoreductase 1 is essential for ozone-induced oxidative stress in mice and humans.	2009-07	19059883
Ozone stress down-regulates the expression of cystic fibrosis transmembrane conductance regulator in human bronchial epithelial cells.	2009-05-15	19061877
Age, strain, and gender as factors for increased sensitivity of the mouse lung to inhaled ozone.	2009-02	19066396
Role of metallothionein in lung inflammation induced by ozone exposure in mice.	2008-12-15	18929643
Role of p38 mitogen-activated protein kinase in ozone-induced airway hyperresponsiveness and inflammation.	2008-12-14	18926814
Ozone exposure, antioxidant genes, and lung function in an elderly cohort: VA normative aging study.	2008-11	18524839
Environmental public health tracking of childhood asthma using California health interview survey, traffic, and outdoor air pollution data.	2008-09	18795172
Modulation of ozone-induced airway hyperresponsiveness and inflammation by interleukin-13.	2008-09	18417511
Lung inflammation and thrombogenic responses in a time course study of Csb mice exposed to ozone.	2008-08	18381685
Air pollution, airway inflammation, and lung function in a cohort study of Mexico City schoolchildren.	2008-06	18560490
Ozone inhalation induces exacerbation of eosinophilic airway inflammation and hyperresponsiveness in allergen-sensitized mice.	2008-04	18315731
Regulation of caveolin-1 expression, nitric oxide production and tissue injury by tumor necrosis factor-alpha following ozone inhalation.	2008-03-15	18207479
Is there an association between lifetime cumulative exposure and acute pulmonary responses to ozone?	2008-03	18332784
Associations of FcepsilonRIbeta E237G polymorphism with wheezing in Taiwanese schoolchildren.	2008-03	18269668
Air pollution and postneonatal infant mortality in the United States, 1999-2002.	2008-01	18197308
Integrated disinfection by-products (DBP) mixtures research: gene expression alterations in primary rat hepatocyte cultures exposed to DBP mixtures formed by chlorination and ozonation/postchlorination.	2008	18636392
Protective role of matrix metalloproteinase-9 in ozone-induced airway inflammation.	2007-11	18007984
Ozone enhancement of lower airway allergic inflammation is prevented by gamma-tocopherol.	2007-10-15	17854713
Comparative assessment of air pollution-related health risks in Houston.	2007-10	17938725
Air pollution alters brain and pituitary endothelin-1 and inducible nitric oxide synthase gene expression.	2007-10	17662977
Effects of antioxidant enzyme polymorphisms on ozone-induced lung function changes.	2007-10	17652311
Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia.	2007-10	17626835
Type I interleukin-1 receptor is required for pulmonary responses to subacute ozone exposure in mice.	2007-10	17575079
PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells.	2007-07-01	17355223
Attenuation of ozone-induced airway inflammation and hyper-responsiveness by c-Jun NH2 terminal kinase inhibitor SP600125.	2007-07	17460151
Role of surfactant protein-A (SP-A) in lung injury in response to acute ozone exposure of SP-A deficient mice.	2007-04-01	17307210
Parental smoking modifies the relation between genetic variation in tumor necrosis factor-alpha (TNF) and childhood asthma.	2007-04	17450233
Atmospheric photochemical transformations enhance 1,3-butadiene-induced inflammatory responses in human epithelial cells: The role of ozone and other photochemical degradation products.	2007-03-20	16860297
Ozone induces clear cellular and molecular responses in the mouse lung independently of the transcription-coupled repair status.	2007-03	17095637
Lung injury after ozone exposure is iron dependent.	2007-01	16905637
Ozonation of human blood induces a remarkable upregulation of heme oxygenase-1 and heat stress protein-70.	2007	18274635
Upregulation of substance P receptor expression by calcitonin gene-related peptide, a possible cooperative action of two neuropeptides involved in airway inflammation.	2007	16777450
GSTM1 and GSTP1 and respiratory health in asthmatic children exposed to ozone.	2006-11	16870661
Postnatal lung development: immediate-early gene responses post ozone and LPS exposure.	2006-10	16864405
Wound repair and proliferation of bronchial epithelial cells enhanced by bombesin receptor subtype 3 activation.	2006-07	16426703
Ozone induces oxidative stress in rat alveolar type II and type I-like cells.	2006-06-01	16716893
Pulmonary expression of preproET-1 and preproET-3 mRNAs is altered reciprocally in rats after inhalation of air pollutants.	2006-06	16741034
Elevation of susceptibility to ozone-induced acute tracheobronchial injury in transgenic mice deficient in Clara cell secretory protein.	2006-05-15	16226776
Associations of tumor necrosis factor G-308A with childhood asthma and wheezing.	2006-05-01	16456144
Increased pulmonary responses to acute ozone exposure in obese db/db mice.	2006-05	16373670
Efficiency of tazobactam/piperacillin in lethal peritonitis is enhanced after preconditioning of rats with O3/O2-pneumoperitoneum.	2006-01	16369182
Augmented responses to ozone in obese carboxypeptidase E-deficient mice.	2006-01	16002559
Ozone enhances diesel exhaust particles (DEP)-induced interleukin-8 (IL-8) gene expression in human airway epithelial cells through activation of nuclear factors- kappaB (NF-kappaB) and IL-6 (NF-IL6).	2005-12	16819095
The association between fatal coronary heart disease and ambient particulate air pollution: Are females at greater risk?	2005-12	16330354
Acute ozone-induced differential gene expression profiles in rat lung.	2005-12	16330353
Differential regulation of the lung endothelin system by urban particulate matter and ozone.	2005-11	16081523
Systemic responses to inhaled ozone in mice: cachexia and down-regulation of liver xenobiotic metabolizing genes.	2005-10-15	16183385
Relation between ambient air quality and selected birth defects, seven county study, Texas, 1997-2000.	2005-08-01	15987727
Molecular analysis of hprt mutation in B6C3F1 mice exposed to ozone alone and combined treatment of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and/or dibutyl phthalate for 32 and 52 weeks.	2004-12	15613823
Inactivation of human immunodeficiency virus type 1 by ozone in vitro.	1991-10-01	1717074

Patents

Sample Use Guides

In Vivo Use Guide

patients with fibromyalgia: autohemotransfusion in 55 patients and by ozone rectal insufflations in 10 patients, according to SIOOT (Scientific Society of Oxygen Ozone Therapy) protocols, twice a week for one month and then twice a month as maintenance therapy.

Route of Administration: Rectal

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:36:56 GMT 2025` Edited by `admin` on `Mon Mar 31 18:36:56 GMT 2025`
Record UNII	66H7ZZK23N
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

OZONE [FCC]

Preferred Name

English

OZONE

Official Name

English

TRIATOMIC OXYGEN

Common Name

English

Ozone [WHO-DD]

Common Name

English

OZONE [HSDB]

Common Name

English

OZONE [MI]

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 173.368