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Details

Stereochemistry ABSOLUTE
Molecular Formula C20H26N4O4S.ClH
Molecular Weight 454.971
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of VATINOXAN HYDROCHLORIDE

SMILES

Cl.[H][C@@]12C[C@@]3(CNC(=O)N3CCNS(C)(=O)=O)CCN1CCC4=C2OC5=C4C=CC=C5

InChI

InChIKey=UTMOWVIYZQWJHT-VASSOYJASA-N
InChI=1S/C20H26N4O4S.ClH/c1-29(26,27)22-8-11-24-19(25)21-13-20(24)7-10-23-9-6-15-14-4-2-3-5-17(14)28-18(15)16(23)12-20;/h2-5,16,22H,6-13H2,1H3,(H,21,25);1H/t16-,20+;/m0./s1

HIDE SMILES / InChI

Molecular Formula C20H26N4O4S
Molecular Weight 418.51
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

MK-467 (also known as Vatinoxan) is a peripheral α2 -adrenoceptor antagonist patented by American multinational pharmaceutical company Merck & Co., Inc. for treatment of hypertension, diabetes, obesity, and as blood platelet aggregation. In preclinical models Vatinoxan administration alleviate the unwanted cardiopulmonary effects of various α2-agonists (such as bradycardia, vasoconstriction, and hypoxemia). Because of its low lipophilicity MK-467 poorly penetrates the mammalian central nervous system and preserve the centrally mediated desired effects of α2-agonists. Simultaneous intramuscular injection of MK-467 hastened the absorption of α2-agonist drugs, which was manifested by rapid onset of sedation.

Approval Year

PubMed

PubMed

TitleDatePubMed
Patents

Patents

Substance Class Chemical
Created
by admin
on Fri Dec 15 15:52:09 GMT 2023
Edited
by admin
on Fri Dec 15 15:52:09 GMT 2023
Record UNII
66932R910R
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
VATINOXAN HYDROCHLORIDE
USAN  
Official Name English
MK-467
Code English
METHANESULFONAMIDE, N-(2-((2R,12BS)-1,3,4,6,7,12B-HEXAHYDRO-2'-OXOSPIRO(2H-BENZOFURO(2,3-A)QUINOLIZINE-2,4'-IMIDAZOLIDIN)-3'-YL)ETHYL)-, HYDROCHLORIDE (1:1)
Systematic Name English
N-(2-((2R,12BS)-2'-OXO-1,3,4,6,7,12B-HEXAHYDROSPIRO(BENZOFURO(2,3-A)QUINOLIZINE-2,4'-IMIDAZOLIDIN)-3'-YL)ETHYL)METHANESULFONAMIDE MONOHYDROCHLORIDE
Systematic Name English
VATINOXAN HYDROCHLORIDE [USAN]
Common Name English
Code System Code Type Description
PUBCHEM
182976
Created by admin on Fri Dec 15 15:52:09 GMT 2023 , Edited by admin on Fri Dec 15 15:52:09 GMT 2023
PRIMARY
EPA CompTox
DTXSID30926749
Created by admin on Fri Dec 15 15:52:09 GMT 2023 , Edited by admin on Fri Dec 15 15:52:09 GMT 2023
PRIMARY
FDA UNII
66932R910R
Created by admin on Fri Dec 15 15:52:09 GMT 2023 , Edited by admin on Fri Dec 15 15:52:09 GMT 2023
PRIMARY
NCI_THESAURUS
C171680
Created by admin on Fri Dec 15 15:52:09 GMT 2023 , Edited by admin on Fri Dec 15 15:52:09 GMT 2023
PRIMARY
RXCUI
2601583
Created by admin on Fri Dec 15 15:52:09 GMT 2023 , Edited by admin on Fri Dec 15 15:52:09 GMT 2023
PRIMARY
DAILYMED
66932R910R
Created by admin on Fri Dec 15 15:52:09 GMT 2023 , Edited by admin on Fri Dec 15 15:52:09 GMT 2023
PRIMARY
SMS_ID
300000020831
Created by admin on Fri Dec 15 15:52:09 GMT 2023 , Edited by admin on Fri Dec 15 15:52:09 GMT 2023
PRIMARY
CAS
130466-38-5
Created by admin on Fri Dec 15 15:52:09 GMT 2023 , Edited by admin on Fri Dec 15 15:52:09 GMT 2023
PRIMARY
USAN
FG-39
Created by admin on Fri Dec 15 15:52:09 GMT 2023 , Edited by admin on Fri Dec 15 15:52:09 GMT 2023
PRIMARY
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ACTIVE MOIETY