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Description

Davalintide (AC-2307) is a second-generation mimetic of a pancreatic peptide hormone amylin, developed by Amylin Pharmaceuticals. In preclinical models, davalintide possessed enhanced pharmacological properties and was able to reduce food intake. Safety, tolerability, and effect on body weight of subcutaneous davalintide were investigated in obese or overweight subjects. The results of the clinical trial were not reported, but Amylin decided to discontinue davalintide in 2010.

Originator

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Mon Mar 31 20:38:12 GMT 2025
Edited
by admin
on Mon Mar 31 20:38:12 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
668U999F9T
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AC-2307
Preferred Name English
DAVALINTIDE
INN   USAN  
INN   USAN  
Official Name English
davalintide [INN]
Common Name English
AC2307
Code English
DAVALINTIDE [USAN]
Common Name English
L-LYSYL-DES-2-L-SERINE-(4-L-THREONINE(L>T),5-L-ALANINE(S>A),11-L-ARGININE(K>R),18-L-ARGININE(K>R),30-L-ASPARAGINE(G>N),32-L-TYROSINE(P>Y))CALCITONIN-1 ONCORHYNCHUS KETA (CHUM SALMON), CALCITONIN-1 PRECURSOR-(83-114)-PEPTIDAMIDE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29711
Created by admin on Mon Mar 31 20:38:12 GMT 2025 , Edited by admin on Mon Mar 31 20:38:12 GMT 2025
Code System Code Type Description
ChEMBL
CHEMBL2105635
Created by admin on Mon Mar 31 20:38:12 GMT 2025 , Edited by admin on Mon Mar 31 20:38:12 GMT 2025
PRIMARY
USAN
UU-52
Created by admin on Mon Mar 31 20:38:12 GMT 2025 , Edited by admin on Mon Mar 31 20:38:12 GMT 2025
PRIMARY
DRUG BANK
DB14956
Created by admin on Mon Mar 31 20:38:12 GMT 2025 , Edited by admin on Mon Mar 31 20:38:12 GMT 2025
PRIMARY
CAS
863919-85-1
Created by admin on Mon Mar 31 20:38:12 GMT 2025 , Edited by admin on Mon Mar 31 20:38:12 GMT 2025
PRIMARY
PUBCHEM
71587842
Created by admin on Mon Mar 31 20:38:12 GMT 2025 , Edited by admin on Mon Mar 31 20:38:12 GMT 2025
PRIMARY
INN
9124
Created by admin on Mon Mar 31 20:38:12 GMT 2025 , Edited by admin on Mon Mar 31 20:38:12 GMT 2025
PRIMARY
FDA UNII
668U999F9T
Created by admin on Mon Mar 31 20:38:12 GMT 2025 , Edited by admin on Mon Mar 31 20:38:12 GMT 2025
PRIMARY
NCI_THESAURUS
C83650
Created by admin on Mon Mar 31 20:38:12 GMT 2025 , Edited by admin on Mon Mar 31 20:38:12 GMT 2025
PRIMARY
SMS_ID
300000025258
Created by admin on Mon Mar 31 20:38:12 GMT 2025 , Edited by admin on Mon Mar 31 20:38:12 GMT 2025
PRIMARY
From To
1_2 1_7
Related Record Type Details
DAVALINTIDE
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [1_32] TYROSINAMIDE, L- 05LU01CS4T
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL
NIH
NCATS
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