Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C24H25ClN2O.ClH |
| Molecular Weight | 429.382 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CN1[C@H]2CC[C@@H]1[C@H]([C@H](C2)C3=CC=C(Cl)C=C3)C4=CC(=NO4)C5=CC=C(C)C=C5
InChI
InChIKey=IZMZEMAKFSYLMD-SXBQIKTFSA-N
InChI=1S/C24H25ClN2O.ClH/c1-15-3-5-17(6-4-15)21-14-23(28-26-21)24-20(16-7-9-18(25)10-8-16)13-19-11-12-22(24)27(19)2;/h3-10,14,19-20,22,24H,11-13H2,1-2H3;1H/t19-,20+,22+,24-;/m0./s1
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C24H25ClN2O |
| Molecular Weight | 392.921 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
RTI-336 was developed as a selective dopamine transporter (DAT) inhibitor. It is known that DAT inhibitors have been developed as a promising treatment approach for cocaine dependence. RTI-336 can be a useful adjunct in the treatment of cocaine dependence because preclinical data has shown that this drug inhibits DAT with a slower onset and offset rate than cocaine and with less abuse potential and psychomotor stimulant activity. RTI-336 participated in phase I clinical trial where it showed the excellent safety and tolerability, and thus further studies in humans are warranted.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 19:05:27 GMT 2023
by
admin
on
Fri Dec 15 19:05:27 GMT 2023
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| Record UNII |
667440B6Z7
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| Record Status |
Validated (UNII)
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| Record Version |
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667440B6Z7
Created by
admin on Fri Dec 15 19:05:27 GMT 2023 , Edited by admin on Fri Dec 15 19:05:27 GMT 2023
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11524766
Created by
admin on Fri Dec 15 19:05:27 GMT 2023 , Edited by admin on Fri Dec 15 19:05:27 GMT 2023
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C506585
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admin on Fri Dec 15 19:05:27 GMT 2023 , Edited by admin on Fri Dec 15 19:05:27 GMT 2023
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204069-50-1
Created by
admin on Fri Dec 15 19:05:27 GMT 2023 , Edited by admin on Fri Dec 15 19:05:27 GMT 2023
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PARENT -> SALT/SOLVATE |
