LOW AFFINITY IMMUNOGLOBULIN EPSILON FC RECEPTOR

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 20:18:45 GMT 2025` Edited by `admin` on `Tue Apr 01 20:18:45 GMT 2025`
Protein Sub Type
Record UNII	662XT84BPG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CD-23

Preferred Name

English

LOW AFFINITY IMMUNOGLOBULIN EPSILON FC RECEPTOR

Common Name

English

LYMPHOCYTE IGE RECEPTOR

Common Name

English

IGEBF

Common Name

English

FCER2

Common Name

English

BLAST-2

Common Name

English

CD-23A

Common Name

English

FCE2

Common Name

English

C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER J

Common Name

English

CLEC4J

Common Name

English

IMMUNOGLOBULIN E-BINDING FACTOR

Common Name

English

FC-EPSILON-RII

Common Name

English

Code System Code Type Description

FDA UNII

662XT84BPG

Created by admin on Tue Apr 01 20:18:45 GMT 2025 , Edited by admin on Tue Apr 01 20:18:45 GMT 2025

PRIMARY

UNIPROT

P06734

Created by admin on Tue Apr 01 20:18:45 GMT 2025 , Edited by admin on Tue Apr 01 20:18:45 GMT 2025

PRIMARY

From	To
1_160	1_288
1_163	1_174
1_191	1_282
1_259	1_273

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_63

Related Record Type Details


					8Z13S29R5A

GOMILIXIMAB

INHIBITOR -> TARGET


					XK0D8BK5WY

MEDI-4212

INHIBITOR -> TARGET

Comments:

MEDI4212 is directed against IgE, effectively blocking Fc?RI and CD23, and thereby preventing an IgE-mediated response.

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_17] [1_18]		CYSTEINE		S-PALMITOYL CYSTEINE	08WQ73S7SV

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL