Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C6H7N5O |
| Molecular Weight | 165.1529 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1C=NC2=C1C(=O)NC(N)=N2
InChI
InChIKey=FZWGECJQACGGTI-UHFFFAOYSA-N
InChI=1S/C6H7N5O/c1-11-2-8-4-3(11)5(12)10-6(7)9-4/h2H,1H3,(H3,7,9,10,12)
| Molecular Formula | C6H7N5O |
| Molecular Weight | 165.1529 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Separation and identification of purine nucleosides in the urine of patients with malignant cancer by reverse phase liquid chromatography/electrospray tandem mass spectrometry. | 2009-05 |
|
| O(6)-methylguanine-DNA methyltransferase depletion and DNA damage in patients with melanoma treated with temozolomide alone or with lomeguatrib. | 2009-04-21 |
|
| A phase I study of extended dosing with lomeguatrib with temozolomide in patients with advanced melanoma. | 2009-04-21 |
|
| Deciphering peculiar protein-protein interacting modules in Deinococcus radiodurans. | 2009-04-08 |
|
| Dietary variables associated with DNA N7-methylguanine levels and O6-alkylguanine DNA-alkyltransferase activity in human colorectal mucosa. | 2009-04 |
|
| Recognition and processing of a new repertoire of DNA substrates by human 3-methyladenine DNA glycosylase (AAG). | 2009-03-10 |
|
| Biomarkers of induced active and passive smoking damage. | 2009-03 |
|
| Toward a molecular equivalent dose: use of the medaka model in comparative risk assessment. | 2009-03 |
|
| Time course evaluation of N-nitrosodialkylamines-induced DNA alkylation and oxidation in liver of mosquito fish. | 2009-01-15 |
|
| Characterization of the meningococcal DNA glycosylase Fpg involved in base excision repair. | 2009-01-09 |
|
| Neopterin, a marker of immune response, and 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress, correlate at high age as determined by automated simultaneous high-performance liquid chromatography analysis of human urine. | 2008-12-15 |
|
| Correlation between the urine profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolites and N7-methylguanine in urothelial carcinoma patients. | 2008-12 |
|
| Repeated measurements of urinary methylated/oxidative DNA lesions, acute toxicity, and mutagenicity in coke oven workers. | 2008-12 |
|
| Contribution of natural inhibitors to the understanding of the PI3K/PDK1/PKB pathway in the insulin-mediated intracellular signaling cascade. | 2008-11 |
|
| Substrate binding pocket residues of human alkyladenine-DNA glycosylase critical for methylating agent survival. | 2008-10-01 |
|
| Overexpression, purification and characterization of functional calf purine nucleoside phosphorylase (PNP). | 2008-10 |
|
| Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine. | 2008-09-03 |
|
| A flexible loop as a functional element in the catalytic mechanism of nucleoside hydrolase from Trypanosoma vivax. | 2008-08-08 |
|
| Human methyl purine DNA glycosylase and DNA polymerase beta expression collectively predict sensitivity to temozolomide. | 2008-08 |
|
| Stacking efficiency and flexibility analysis of aromatic amino acids in cap-binding proteins. | 2008-06 |
|
| Monitoring of dimethyl sulphate-induced N3-methyladenine, N7-methylguanine and O(6)-methylguanine DNA adducts using reversed-phase high performance liquid chromatography and mass spectrometry. | 2008-05-01 |
|
| Synthesis and biological evaluation of trimethyl-substituted cap analogs. | 2008-02-01 |
|
| The Argonaute protein family. | 2008 |
|
| Biological significance of DNA adducts investigated by simultaneous analysis of different endpoints of genotoxicity in L5178Y mouse lymphoma cells treated with methyl methanesulfonate. | 2007-12-01 |
|
| Prospective study of urinary excretion of 7-methylguanine and the risk of lung cancer: Effect modification by mu class glutathione-S-transferases. | 2007-10-01 |
|
| Triazene compounds: mechanism of action and related DNA repair systems. | 2007-10 |
|
| Lung cancer risk and variation in MGMT activity and sequence. | 2007-08-01 |
|
| Structural and functional insights into Mimivirus ORFans. | 2007-05-09 |
|
| Human colorectal mucosal O6-alkylguanine DNA-alkyltransferase activity and DNA-N7-methylguanine levels in colorectal adenoma cases and matched referents. | 2007-03 |
|
| Methylation: a regulator of HIV-1 replication? | 2007-02-02 |
|
| Kinetics of C. elegans DcpS cap hydrolysis studied by fluorescence spectroscopy. | 2007 |
|
| Decreasing urinary PAH metabolites and 7-methylguanine after smoking cessation. | 2006-08 |
|
| Theoretical study of the ground and excited states of 7-methyl guanine and 9-methyl guanine: comparison with experiment. | 2006-07-14 |
|
| Probing the mechanism of purine nucleoside phosphorylase by steady-state kinetic studies and ligand binding characterization determined by fluorimetric titrations. | 2006-05 |
|
| Simultaneous quantitation of 7-methyl- and O6-methylguanine adducts in DNA by liquid chromatography-positive electrospray tandem mass spectrometry. | 2006-04-03 |
|
| Bladder tumor contains higher N7-methylguanine levels in DNA than adjacent normal bladder epithelium. | 2006-04 |
|
| Flavonoids suppresses the enhancing effect of beta-carotene on DNA damage induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A549 cells. | 2006-03-25 |
|
| A new protein superfamily includes two novel 3-methyladenine DNA glycosylases from Bacillus cereus, AlkC and AlkD. | 2006-03 |
|
| Synergistic DNA damage and lipid peroxidation in cultured human white blood cells exposed to 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone and ultraviolet A. | 2006-03 |
|
| The efficiency of hypoxanthine excision by alkyladenine DNA glycosylase is altered by changes in nearest neighbor bases. | 2005-09-28 |
|
| Structure, reactivity and solution behaviour of [Re(ser)(7-MeG)(CO)(3)] and [Re(ser)(3-pic)(CO)(3)]: "nucleoside-mimicking" complexes based on the fac-[Re(CO)(3)](+) moiety. | 2005-09-07 |
|
| Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1. | 2005-05-01 |
|
| Stable isotope labeling-mass spectrometry analysis of methyl- and pyridyloxobutyl-guanine adducts of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in p53-derived DNA sequences. | 2005-02-15 |
|
| Lack of EGF receptor contributes to drug sensitivity of human germline cells. | 2005-01-31 |
|
| Metal ion complexes of macrocyclic polyamines enhance both the phosphate hydrolysis and imidazole ring opening of RNA 5'-cap structure. | 2005-01 |
|
| Rapid and sensitive quantification of urinary N7-methylguanine by isotope-dilution liquid chromatography/electrospray ionization tandem mass spectrometry with on-line solid-phase extraction. | 2005 |
|
| Analysis of 7-methylguanine using isotope dilution and gas chromatography/electron-capture negative chemical ionization mass spectrometry. | 2005 |
|
| Interspecies dose extrapolation for inhaled dimethyl sulfate: a PBPK model-based analysis using nasal cavity N7-methylguanine adducts. | 2004-08 |
|
| DNA methylation, cell proliferation, and histopathology in rats following repeated inhalation exposure to dimethyl sulfate. | 2004-08 |
|
| Determination of N7-methylguanine in DNA of white blood cells from cancer patients treated with dacarbazine. | 1992-07 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 23:09:55 GMT 2025
by
admin
on
Mon Mar 31 23:09:55 GMT 2025
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| Record UNII |
661J4K04NB
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| Record Status |
FAILED
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| Record Version |
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DTXSID9020873
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193444
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209-431-0
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28664
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7-Methylguanine
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