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Details

Stereochemistry ACHIRAL
Molecular Formula C11H12N2
Molecular Weight 172.2264
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TRYPTOLINE

SMILES

C1CC2=C(CN1)NC3=CC=CC=C23

InChI

InChIKey=CFTOTSJVQRFXOF-UHFFFAOYSA-N
InChI=1S/C11H12N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-4,12-13H,5-7H2

HIDE SMILES / InChI

Molecular Formula C11H12N2
Molecular Weight 172.2264
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Tryptoline (also known as a tetrahydronorharmane), a metabolite of tryptamine, is an inhibitor of the reuptake of serotonin. Some in vitro experiments have shown that tryptoline prevents the lipid peroxidation induced by hydrogen peroxide and thus this compound can be further investigated as a neuroprotective agent.

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct

PubMed

Sample Use Guides

In Vivo Use Guide
in rats: 98 mg/kg was calculated for i.p. injection
Route of Administration: Intraperitoneal
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
65027TMI0H
Record Status Validated (UNII)
Record Version