SODIUM TUNGSTATE

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	2Na.O4W
Molecular Weight	293.82
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[Na+].[O-][W]([O-])(=O)=O

InChI

InChIKey=XMVONEAAOPAGAO-UHFFFAOYSA-N

InChI=1S/2Na.4O.W/q2*+1;;;2*-1;

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	O4W
Molecular Weight	247.84
Charge	-2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5230113 | https://www.ncbi.nlm.nih.gov/pubmed/9076617 | https://www.cftungsten.com/tungstic-acid/ | http://reag.paperplane.io/00001511.htm

Tungstic acid is a fairly strong acid, it catalyzes the oxidation by hydrogen peroxide of alkenes to the corresponding epoxides. Tungstic acid is widely used in the production of tungsten metal, alloys, and is used as a mordant for textiles and plastics. Tungstic acid has been reported to rapidly precipitate the quaternary ammonium cations in cholinergic nerve terminals, such as ACh or choline. Also, tungsten dietary supplementation has successfully been used to reduce xanthine oxide (XO) activity, resulting in decreased gastrointestinal (GI) mucosal damage because of lowered XO activity. Tungstic acid has been shown to effectively antagonize stress-induced gastric ulcers, possibly by decreasing motility and mass cell degranulation. Tungstic acid gel has been used as an epileptogenic agent since 1960. Epilepsy produced by this agent is characterized by good localization, short latency and limited duration. It is effective in cerebral cortex, brain stem and spinal cord.

Approval Year

PubMed

Title	Date	PubMed
The preparation of tungstic acid gel and its use in the production of experimental epilepsy.	1967 Mar	5230113
Streamline pattern and velocity components of flow in a model of a branching coronary vessel--possible functional implication for the development of localized platelet deposition in vitro.	1986 Mar	3702772
Tungstic acid reduction of cold-resistant stress-induced ulceration in rats.	1997 Jan	9076617
Genotoxic changes to rodent cells exposed in vitro to tungsten, nickel, cobalt and iron.	2014 Mar 10	24619124
Tungsten-induced carcinogenesis in human bronchial epithelial cells.	2015 Oct 1	26164860

Sample Use Guides

In Vivo Use Guide

Sprague-Dawley rats were restrained at 4 degrees C for 2 h (stress). Tungstic acid in a single dose of 0.01, 0.1, 1, 10, 100 or 300 mg/kg (dissolved in distilled water) was administered intragastrically to animals 30 min prior to stress. Doses of tungstic acid of 1 mg/kg and higher significantly decreased ulcers.

Route of Administration: Intragastric

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:15:43 GMT 2023` Edited by `admin` on `Sat Dec 16 08:15:43 GMT 2023`
Record UNII	64LRH4405G
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SODIUM TUNGSTATE

Common Name

English

TUNGSTIC ACID (H2WO4), DISODIUM SALT

Common Name

English

SODIUM TUNGSTATE(VI) [MI]

Common Name

English

TUNGSTATE (WO42-), SODIUM (1:2), (T-4)-

Common Name

English

DISODIUM TUNGSTATE

Common Name

English

SODIUM TUNGSTEN OXIDE (NA2WO4)

Common Name

English

SODIUM TUNGSTATE(VI)

Common Name

English

DISODIUM TETRAOXOTUNGSTATE(2-)

Common Name

English

DISODIUM TETRAOXATUNGSTATE(2-)

Common Name

English

Code System Code Type Description

WIKIPEDIA

SODIUM TUNGSTATE