AZD-0424

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C25H29ClN6O5
Molecular Weight	528.988
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)OC1=CC(OCCN2CCN(CC2)C(C)=O)=CC3=C1C(NC4=C5OCOC5=NC=C4Cl)=NC=N3

InChI

InChIKey=MVWATCATLSSVBH-UHFFFAOYSA-N

InChI=1S/C25H29ClN6O5/c1-15(2)37-20-11-17(34-9-8-31-4-6-32(7-5-31)16(3)33)10-19-21(20)24(29-13-28-19)30-22-18(26)12-27-25-23(22)35-14-36-25/h10-13,15H,4-9,14H2,1-3H3,(H,27,28,29,30)

HIDE SMILES / InChI

Molecular Formula	C25H29ClN6O5
Molecular Weight	528.988
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/29438361 | https://clinicaltrials.gov/ct2/show/NCT01668550

AZD0424, a dual selective Src/Abl kinase inhibitor that has shown evidence of anti-tumor activity in pre-clinical studies. AZD0424 participated in phase I clinical trials in patients with advanced solid tumors, but this study was terminated because of insufficient evidence of efficacy as monotherapy.

Originator

Approval Year

PubMed

Title	Date	PubMed
Src kinase inhibitors induce apoptosis and mediate cell cycle arrest in lymphoma cells.	2007 Oct	17704648
Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors.	2015 Apr	25662515

Patents

Sample Use Guides

In Vivo Use Guide

AZD0424 will be administered as a flat dose orally once a day. One treatment cycle consists of 28 days of continuous drug administration with AZD0424, with the flexibility to introduce treatment breaks if required due to cumulative toxicity.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:49:46 GMT 2023` Edited by `admin` on `Sat Dec 16 10:49:46 GMT 2023`
Record UNII	642PS51324
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AZD-0424

Common Name

English

7-(2-(4-ACETYLPIPERAZIN-1-YL)ETHOXY)-4-(5-CHLORO-2,3-METHYLENEDIOXYPYRIDIN-4-YLAMINO)-5-ISOPROPOXYQUINAZOLINE

Systematic Name

English

AZD0424

Code

English

PIPERAZINE, 1-ACETYL-4-(2-((4-((6-CHLORO-1,3-DIOXOLO(4,5-B)PYRIDIN-7-YL)AMINO)-5-(1-METHYLETHOXY)-7-QUINAZOLINYL)OXY)ETHYL)-

Systematic Name

English

ETHANONE, 1-(4-(2-((4-((6-CHLORO-1,3-DIOXOLO(4,5-B)PYRIDIN-7-YL)AMINO)-5-(1-METHYLETHOXY)-7-QUINAZOLINYL)OXY)ETHYL)-1-PIPERAZINYL)-

Systematic Name

English

Code System Code Type Description

NCI_THESAURUS

C102976