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Details

Stereochemistry ACHIRAL
Molecular Formula C25H29ClN6O5
Molecular Weight 528.9889
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AZD-0424

SMILES

CC(C)Oc1cc(cc2c1c(ncn2)Nc3c(cnc4c3OCO4)Cl)OCCN5CCN(CC5)C(=O)C

InChI

InChIKey=MVWATCATLSSVBH-UHFFFAOYSA-N
InChI=1S/C25H29ClN6O5/c1-15(2)37-20-11-17(34-9-8-31-4-6-32(7-5-31)16(3)33)10-19-21(20)24(29-13-28-19)30-22-18(26)12-27-25-23(22)35-14-36-25/h10-13,15H,4-9,14H2,1-3H3,(H,27,28,29,30)

HIDE SMILES / InChI

Molecular Formula C25H29ClN6O5
Molecular Weight 528.9889
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

AZD0424, a dual selective Src/Abl kinase inhibitor that has shown evidence of anti-tumor activity in pre-clinical studies. AZD0424 participated in phase I clinical trials in patients with advanced solid tumors, but this study was terminated because of insufficient evidence of efficacy as monotherapy.

Approval Year

PubMed

PubMed

TitleDatePubMed
Src kinase inhibitors induce apoptosis and mediate cell cycle arrest in lymphoma cells.
2007 Oct
Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors.
2015 Apr
Patents

Sample Use Guides

AZD0424 will be administered as a flat dose orally once a day. One treatment cycle consists of 28 days of continuous drug administration with AZD0424, with the flexibility to introduce treatment breaks if required due to cumulative toxicity.
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Jun 26 07:48:20 UTC 2021
Edited
by admin
on Sat Jun 26 07:48:20 UTC 2021
Record UNII
642PS51324
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AZD-0424
Common Name English
7-(2-(4-ACETYLPIPERAZIN-1-YL)ETHOXY)-4-(5-CHLORO-2,3-METHYLENEDIOXYPYRIDIN-4-YLAMINO)-5-ISOPROPOXYQUINAZOLINE
Systematic Name English
AZD0424
Code English
PIPERAZINE, 1-ACETYL-4-(2-((4-((6-CHLORO-1,3-DIOXOLO(4,5-B)PYRIDIN-7-YL)AMINO)-5-(1-METHYLETHOXY)-7-QUINAZOLINYL)OXY)ETHYL)-
Systematic Name English
ETHANONE, 1-(4-(2-((4-((6-CHLORO-1,3-DIOXOLO(4,5-B)PYRIDIN-7-YL)AMINO)-5-(1-METHYLETHOXY)-7-QUINAZOLINYL)OXY)ETHYL)-1-PIPERAZINYL)-
Systematic Name English
Code System Code Type Description
FDA UNII
642PS51324
Created by admin on Sat Jun 26 07:48:20 UTC 2021 , Edited by admin on Sat Jun 26 07:48:20 UTC 2021
PRIMARY
ChEMBL
CHEMBL3545177
Created by admin on Sat Jun 26 07:48:20 UTC 2021 , Edited by admin on Sat Jun 26 07:48:20 UTC 2021
PRIMARY
CAS
692054-06-1
Created by admin on Sat Jun 26 07:48:20 UTC 2021 , Edited by admin on Sat Jun 26 07:48:20 UTC 2021
PRIMARY
DRUG BANK
DB13088
Created by admin on Sat Jun 26 07:48:20 UTC 2021 , Edited by admin on Sat Jun 26 07:48:20 UTC 2021
PRIMARY
PUBCHEM
9893171
Created by admin on Sat Jun 26 07:48:20 UTC 2021 , Edited by admin on Sat Jun 26 07:48:20 UTC 2021
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
INHIBITOR