Details
Stereochemistry | RACEMIC |
Molecular Formula | C13H19NO3.ClH |
Molecular Weight | 273.756 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.COCCCNCC1COC2=C(O1)C=CC=C2
InChI
InChIKey=ZFKJIMJKFOYFAL-UHFFFAOYSA-N
InChI=1S/C13H19NO3.ClH/c1-15-8-4-7-14-9-11-10-16-12-5-2-3-6-13(12)17-11;/h2-3,5-6,11,14H,4,7-10H2,1H3;1H
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C13H19NO3 |
Molecular Weight | 237.2949 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
DescriptionCurator's Comment: Description was created based on several sources, including
http://journals.co.za/docserver/fulltext/savet/34/3/3101.pdf?expires=1481264914&id=id&accname=guest&checksum=0303CCDDD5B9B7E6FBAC76070B74B0C0
Curator's Comment: Description was created based on several sources, including
http://journals.co.za/docserver/fulltext/savet/34/3/3101.pdf?expires=1481264914&id=id&accname=guest&checksum=0303CCDDD5B9B7E6FBAC76070B74B0C0
HA-242, a benzodioxan derivative, is a muscle relaxant. It can be used for the treatment of central nervous muscular spasticity. Was marketed under the name Quiloflex. Quiloflex (HA-242) is a reflex inhibitor used in human medicine for the symptomatic treatment of spasticity due to pyramidal tract lesions. Quiloflex was also used for casting cattle and horses, and although well tolerated at a dosage of 1-8 mg/kg body wt. in cattle, it was unsuitable for use in this species as the onset of relaxation was slow and the sedation prolonged. A dosage of 6 mg/kg i/m in horses gave relaxation suitable for surgery in 30 min.
CNS Activity
Originator
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4313800
Curator's Comment: In 1959 Klupp & Streller reported on the muscle relaxant effect of 2-(3'- methoxypropylaminomethyl)-1 :4-benzodioxane (HA-242)
Approval Year
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Quiloflex Approved UseQuiloflex is a reflex inhibitor used in human medicine for the symptomatic
treatment of spasticity due to pyramidal tract lesions. |
|||
Primary | Quiloflex Approved UseMuscle Spasticity therapy, Paralysis therapy |
Sample Use Guides
In Vivo Use Guide
Sources: https://eurekamag.com/research/014/630/014630763.php
Cattle and horses: A dosage of 6 mg/kg i/m in horses gave relaxation suitable for surgery in 30 min.
Route of Administration:
Intramuscular
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:20:41 GMT 2023
by
admin
on
Sat Dec 16 08:20:41 GMT 2023
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Record UNII |
642H581IUJ
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Record Status |
Validated (UNII)
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Record Version |
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ACTIVE MOIETY |