Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C5H10N2O3 |
Molecular Weight | 146.1445 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
N[C@H](CCC(N)=O)C(O)=O
InChI
InChIKey=ZDXPYRJPNDTMRX-GSVOUGTGSA-N
InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m1/s1
Molecular Formula | C5H10N2O3 |
Molecular Weight | 146.1445 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/23075590
Sources: https://www.ncbi.nlm.nih.gov/pubmed/23075590
D-glutamine is an unnatural D type stereoisomer of glutamine which is one of the 20 amino acids encoded by the standard genetic code.
Approval Year
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11058864
It was evaluated the effects of the interaction between mechanical strain and glutamine supplementation in human Caco-2 intestinal epithelial cells, and pursued the finding of equivalent effects of L- and D-glutamine in Caco-2, HT-29, and primary malignant human colonocytes. Caco-2 cells were subjected to repetitive strain in media containing 2 mmol/L of L-glutamine and media supplemented with L- or D-glutamine. Deformation at 10 cpm and L-glutamine supplementation from 2 to 5 mmol/L concentrations independently stimulated Caco-2 proliferation; the combination further increased proliferation. D-Glutamine supplementation yielded similar results, although with lesser potency. Furthermore, both L- and D-glutamine equivalently reduced Caco-2 dipeptidyl dipeptidase activity. The effects of each isoform were blocked by 1 to 3 mmol/L acivicin, a selective antagonist of glutamine metabolism.
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:52:43 UTC 2023
by
admin
on
Sat Dec 16 08:52:43 UTC 2023
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Record UNII |
63HB36CA2Y
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Record Status |
Validated (UNII)
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Record Version |
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