BISNAFIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C32H28N6O8
Molecular Weight	624.6001
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@H](CNCCNC[C@@H](C)N1C(=O)C2=CC=CC3=CC(=CC(C1=O)=C23)[N+]([O-])=O)N4C(=O)C5=CC=CC6=CC(=CC(C4=O)=C56)[N+]([O-])=O

InChI

InChIKey=PXBZKHOQHTVCSQ-QZTJIDSGSA-N

InChI=1S/C32H28N6O8/c1-17(35-29(39)23-7-3-5-19-11-21(37(43)44)13-25(27(19)23)31(35)41)15-33-9-10-34-16-18(2)36-30(40)24-8-4-6-20-12-22(38(45)46)14-26(28(20)24)32(36)42/h3-8,11-14,17-18,33-34H,9-10,15-16H2,1-2H3/t17-,18-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C32H28N6O8
Molecular Weight	624.6001
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9740543 | https://www.ncbi.nlm.nih.gov/pubmed/8174127

Bisnafide (previously known as DMP 840), a bis-naphthalimide derivative that was developed by Bristol-Myers Squibb as a potential anticancer agent. Bisnafide acts as DNA intercalator and topo II inhibitor. This drug participated in phase I clinical trials in pediatric patients with refractory solid tumors. However, further, development has been discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed

Sample Use Guides

In Vivo Use Guide

10 patients with refractory pediatric solid tumors to this Phase I study of DMP 840 given intravenously by short infusion daily for 5 days

Route of Administration: Intravenous

In Vitro Use Guide

DMP 840 exhibits potent antiproliferative activity in vitro against a variety of human and murine leukemia and solid tumor cell lines in culture, with inhibitory doses that reduce the number of treated cells to one half (IC50) values ranging from 2.3 to 53 nM.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:57:22 UTC 2023` Edited by `admin` on `Sat Dec 16 16:57:22 UTC 2023`
Record UNII	62H4W26906
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BISNAFIDE

Official Name

English

Bisnafide [WHO-DD]

Common Name

English

bisnafide [INN]

Common Name

English

1H-BENZ(DE)ISOQUINOLINE-1,3(2H)-DIONE, 2,2'-(1,2-ETHANEDIYLBIS(IMINO((1R)-1-METHYL-2,1-ETHANEDIYL)))BIS(5-NITRO-

Common Name

English

N,N'-(ETHYLENEBIS(IMINO((R)-1-METHYLETHYLENE)))BIS(3-NITRONAPHTHALIMIDE)

Common Name

English

1H-BENZ(DE)ISOQUINOLINE-1,3(2H)-DIONE, 2,2'-(1,2-ETHANEDIYLBIS(IMINO(1-METHYL-2,1-ETHANEDIYL)))BIS(5-NITRO-, (R-(R*,R*))-

Common Name

English

VERSALUMA

Brand Name

English

Classification Tree Code System Code

NCI_THESAURUS

C582