Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C30H39N6O9P |
| Molecular Weight | 658.6392 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=NC(N)=NC2=C1N=CN2[C@@H]3O[C@H](COP(=O)(N[C@@H](C)C(=O)OCC(C)(C)C)OC4=CC=CC5=C4C=CC=C5)[C@@H](O)[C@@]3(C)O
InChI
InChIKey=YFXGICNMLCGLHJ-RSKRLRQZSA-N
InChI=1S/C30H39N6O9P/c1-17(26(38)42-15-29(2,3)4)35-46(40,45-20-13-9-11-18-10-7-8-12-19(18)20)43-14-21-23(37)30(5,39)27(44-21)36-16-32-22-24(36)33-28(31)34-25(22)41-6/h7-13,16-17,21,23,27,37,39H,14-15H2,1-6H3,(H,35,40)(H2,31,33,34)/t17-,21+,23+,27+,30+,46?/m0/s1
| Molecular Formula | C30H39N6O9P |
| Molecular Weight | 658.6392 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
BMS-986094 (formerly known as INX-189), a nucleotide polymerase (NS5B) inhibitor was developed for the treatment of hepatitis C. Drug participated in phase II clinical trials to evaluate its safety and tolerability. However, in 2012 Bristol-Myers Squibb announced discontinues the development due to safety reasons. The U.S. Food and Drug Administration (FDA) subsequently placed BMS-986094 on clinical hold.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus. | 2010 Aug 15 |
|
| INX-08189, a phosphoramidate prodrug of 6-O-methyl-2'-C-methyl guanosine, is a potent inhibitor of hepatitis C virus replication with excellent pharmacokinetic and pharmacodynamic properties. | 2011 May |
|
| Dual pro-drugs of 2'-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus. | 2011 Oct 1 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 01:28:34 GMT 2023
by
admin
on
Sat Dec 16 01:28:34 GMT 2023
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| Record UNII |
62F4AD749Y
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| Record Status |
Validated (UNII)
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| Record Version |
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