Anzurstobart

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 01:42:03 GMT 2025` Edited by `admin` on `Wed Apr 02 01:42:03 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	61FKP5V847
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Anzurstobart

Official Name

English

IMMUNOGLOBULIN G1 (325-ALANINE), ANTI-(HUMAN SIGNAL REGULATORY PROTEIN .ALPHA.) (HUMAN MONOCLONAL BMS-986351 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL BMS-986351 .KAPPA.-CHAIN, DIMER

Preferred Name

English

CC95251

Code

English

ANZURSTOBART [USAN]

Common Name

English

BMS-986351

Code

English

CC 95251 [WHO-DD]

Code

English

CC-95251

Code

English

anzurstobart [INN]

Common Name

English

Code System Code Type Description

INN

12363

Created by admin on Wed Apr 02 01:42:03 GMT 2025 , Edited by admin on Wed Apr 02 01:42:03 GMT 2025

PRIMARY

USAN

JK-191

Created by admin on Wed Apr 02 01:42:03 GMT 2025 , Edited by admin on Wed Apr 02 01:42:03 GMT 2025

PRIMARY

FDA UNII

61FKP5V847

Created by admin on Wed Apr 02 01:42:03 GMT 2025 , Edited by admin on Wed Apr 02 01:42:03 GMT 2025

PRIMARY

SMS_ID

300000034861

Created by admin on Wed Apr 02 01:42:03 GMT 2025 , Edited by admin on Wed Apr 02 01:42:03 GMT 2025

PRIMARY

NCI_THESAURUS

C157501

Created by admin on Wed Apr 02 01:42:03 GMT 2025 , Edited by admin on Wed Apr 02 01:42:03 GMT 2025

PRIMARY

CAS

2543693-10-1

Created by admin on Wed Apr 02 01:42:03 GMT 2025 , Edited by admin on Wed Apr 02 01:42:03 GMT 2025

PRIMARY

From	To
1_22	1_96
1_147	1_203
1_264	1_324
1_370	1_428
1_223	3_214
1_229	2_229
1_232	2_232
2_223	4_214
2_22	2_96
2_147	2_203
2_264	2_324
2_370	2_428
3_134	3_194
3_23	3_88
4_23	4_88
4_134	4_194

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					0QK1IL66VL

TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE SUBSTRATE 1

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					61FKP5V847

ACTIVE MOIETY

Comments:

Prevents CD47/SIRPa-mediated signaling and abrogates the CD47/SIRPa-mediated inhibition of phagocytosis.

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_450] [2_450]	SITE_SPECIFIC			LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_255] [2_255]	SITE_SPECIFIC			METHIONINE SULFOXIDE	XN1XVI4B2C
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL