2-BENZIMIDAZOLETHIOL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H6N2S
Molecular Weight	150.201
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

SC1=NC2=CC=CC=C2N1

InChI

InChIKey=YHMYGUUIMTVXNW-UHFFFAOYSA-N

InChI=1S/C7H6N2S/c10-7-8-5-3-1-2-4-6(5)9-7/h1-4H,(H2,8,9,10)

HIDE SMILES / InChI

Molecular Formula	C7H6N2S
Molecular Weight	150.201
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Transformation of BALB/c-3T3 cells: IV. Rank-ordered potency of 24 chemical responses detected in a sensitive new assay procedure.	1993 Jul	8243401
Determination of very low levels of dissolved mercury(II) and methylmercury in river waters by continuous flow with on-line UV decomposition and cold-vapor atomic fluorescence spectrometry after pre-concentration on a silica gel-2-mercaptobenzimidazol sorbent.	2001 Dec 24	18968467
High-throughput microplate phosphorylation assays based on DevR-DevS/Rv2027c 2-component signal transduction pathway to screen for novel antitubercular compounds.	2005 Apr	15809317
New route to 3-alkylthiazolo[3,2-a]benzimidazole derivatives.	2005 Feb 28	18007303
[A comparative study of the effect of brazidole, amiodarone, sotalol, and hydroxyzine on potassium ionic channels of mollusks neurons].	2005 Jul-Aug	16193648
Prediction of genotoxicity of chemical compounds by statistical learning methods.	2005 Jun	15962942
Synthesis, antibacterial, antifungal activity and interaction of CT-DNA with a new benzimidazole derived Cu(II) complex.	2005 Nov	16006016
Synthesis, structural characterization, and computational studies of novel diiodine adducts with the heterocyclic thioamides N-methylbenzothiazole-2-thione and benzimidazole-2-thione: implications with the mechanism of action of antithyroid drugs.	2005 Nov 14	16271004
Domino Michael addition-carbene rearrangement-cyclization reaction of 1-alkynyl(aryl)-lambda3-bromanes with 2-mercapto-1,3-benzazoles.	2005 Oct 28	16220178
Pressure-tuning Raman spectra of diiodine thioamide compounds: models for antithyroid drug activity.	2006	17497015
Interaction of thioamides, selenoamides, and amides with diiodine.	2006	17497011
Reactions Between Chalcogen Donors and Dihalogens/Interalogens: Typology of Products and Their Characterization by FT-Raman Spectroscopy.	2006	17497008
Bioinorganic chemistry in thyroid gland: effect of antithyroid drugs on peroxidase-catalyzed oxidation and iodination reactions.	2006	17497002
Green route for the heterocyclization of 2-mercaptobenzimidazole into beta-lactum segment derivatives containing -CONH- bridge with benzimidazole: Screening in vitro antimicrobial activity with various microorganisms.	2006 Dec 15	17035035
An analytical method to screen for six thyreostatic drug residues in the thyroid gland and muscle tissues of food producing animals by liquid chromatography with ultraviolet absorption detection and liquid chromatography/mass spectrometry.	2006 Mar-Apr	16640308
Respective contributions of polar vs enthalpy effects in the addition/fragmentation of mercaptobenzoxazole-derived thiyl radicals and analogues to double bonds.	2006 Oct 19	17034153
Experimental and density functional theory study of the vibrational properties of 2-mercaptobenzimidazole in interaction with gold.	2006 Oct 5	17004745
The nature of the chemical bond in linear three-body systems: from i3- to mixed chalcogen/halogen and trichalcogen moieties.	2007	18389065
A novel approach for simultaneous determination of 2-mercaptobenzimidazole and derivatives of 2-thiouracil in animal tissue by gas chromatography/mass spectrometry.	2007	17394127
Zebrafish as a new model for phenotype-based screening of melanogenic regulatory compounds.	2007 Apr	17371438
[Synthesis and bioactivity of N- [4- ( benzimidazole-2-thio) phenyl] -N'-alkyl guanidine derivatives].	2007 Feb	17518042
Benzofused tricycles based on 2-quinoxalinol.	2007 Jan-Feb	17206834
Modification of silica gel by attachment of 2-mercaptobenzimidazole for use in removing Hg(II) from aqueous media: a thermodynamic approach.	2007 Jul 1	17416385
In vivo effects of afobazole (2-mercaptobenzimidazole derivative) on the 7,12-dimethylbenz [alpha]anthracene-induced oncogene and suppressor gene expression.	2007 Nov-Dec	18210756
Synthesis, structural characterization, and biological studies of new antimony(III) complexes with thiones. The influence of the solvent on the geometry of the complexes.	2007 Oct 15	17850141
Syntheses and biological activities of benzimidazolo[2,1-b] benzo[e]thiazepin-5(10H)-ones.	2008 Jan	18072242
Parallel synthesis of 2-sulphanylated bis-benzimidazoles on soluble polymer support.	2008 May-Jun	18407696
Synthesis, structural characterization and biological study of new organotin(IV), silver(I) and antimony(III) complexes with thioamides.	2008 May-Jun	18279959
A polynuclear d10-d10 metal complex with unusual near-infrared luminescence and high thermal stability.	2009 Apr 6	19260683
Application of natural and modified hectorite clays as adsorbents to removal of Cr(VI) from aqueous solution--thermodynamic and equilibrium study.	2009 Dec 15	19643537
Determination of mercury in water and fish samples by cold vapor atomic absorption spectrometry after solid phase extraction on agar modified with 2-mercaptobenzimidazole.	2009 Jan 30	18513869
[Specific effects of selective anxiolytic afobazole on the cardiovascular system].	2009 Jan-Feb	19334510
1H-Benzimidazole-2(3H)-thione.	2009 Mar 14	21582487
Structure and properties of binuclear nitrosyl iron complex with benzimidazole-2-thiolyl.	2009 Mar 14	19240901
New antimony(III) bromide complexes with thioamides: synthesis, characterization, and cytostatic properties.	2009 Mar 2	19235983
3-[(1H-Benzimidazol-2-yl)sulfanyl-methyl]benzonitrile.	2009 May 23	21583209
Determination of thyreostats in urine and thyroid gland by ultra high performance liquid chromatography tandem mass spectrometry.	2009 Nov 13	19406410
2,2'-Bis(methyl-ene)-3,3'-(2-thioxo-2,3-dihydro-1H-benzimidazole-1,3-di-yl)dipropane-nitrile.	2009 Oct 31	21578520
[Effectiveness of combined application of ursosan and anxiolytic 2-mercaptobenzimidazole in early stage of cholelithiasis].	2010	20623958
1,3-Bis(ethoxy-meth-yl)-1H-benzimidazole-2(3H)-thione.	2010 Apr 24	21579184
Inhibitors of the salicylate synthase (MbtI) from Mycobacterium tuberculosis discovered by high-throughput screening.	2010 Dec 3	21053346
Synthesis and controlled hydrolysis of organolanthanide complexes with mono- and dianionic benzimidazole-2-thiolate ligands.	2010 Dec 7	20963210
Structural motifs and biological studies of new antimony(III) iodide complexes with thiones.	2010 Jan 18	20000436
Novel benzo[d]imidazole-2(3H)-thiones as potent inhibitors of the alpha-melanocyte stimulating hormone induced melanogenesis in melanoma B16 cells.	2010 Jul	20606337
Ratiometric surface enhanced Raman quantification of ligand adsorption onto a gold nanoparticle.	2010 Jul 1	20536157
Simultaneous spectrophotometric determination of 2-thiouracil and 2-mercaptobenzimidazole in animal tissue using multivariate calibration methods: concerns and rapid methods for detection.	2010 Mar	20492216
[Antiarrhythmic properties of afobazole and other 2-mercaptobensimidazole derivatives].	2010 May	20597362
Derivatives of benzimidazole pharmacophore: synthesis, anticonvulsant, antidiabetic and DNA cleavage studies.	2010 May	20122763
3-[2-(1H-Benzimidazol-2-ylsulfan-yl)eth-yl]-1,3-oxazolidin-2-one.	2010 Nov 13	21589438
Revisit to the reaction of o-phenylene diamine with thiosemicarbazide to give benzimidazole-2-thione rather than benzotriazine-2-thione and its glycosylation.	2010 Sep	20706960

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:25:47 GMT 2023` Edited by `admin` on `Fri Dec 15 18:25:47 GMT 2023`
Record UNII	619CVM6HOK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

2-BENZIMIDAZOLETHIOL

Systematic Name

English

NSC-21414

Code

English

MERCAPTOBENZIMIDAZOLE [USP IMPURITY]

Common Name

English

MERCAPTOBENZIMIDAZOLE

Common Name

English

2-MERCAPTOBENZIMIDAZOLE

Systematic Name

English

MERCAPTOBENZIMIDAZOLE, 2-

Systematic Name

English

NSC-186246

Code

English

RABEPRAZOLE RELATED COMPOUND C [USP IMPURITY]

Common Name

English

RABEPRAZOLE SODIUM IMPURITY F [EP IMPURITY]

Common Name

English

NCI-C60980

Code

English

1H-BENZIMIDAZOLE-2-THIOL

Systematic Name

English

2-BENZIMIDAZOLETHIOL [MI]

Common Name

English

RABEPRAZOLE RELATED COMPOUND C [USP-RS]

Common Name

English

2H-BENZIMIDAZOLE-2-THIONE, 1,3-DIHYDRO-

Systematic Name

English

NCI-C56268

Code

English

RABEPRAZOLE RELATED COMPOUND C

Common Name

English

LANSOPRAZOLE IMPURITY E [EP IMPURITY]

Common Name

English

1,3-DIHYDRO-2H-BENZIMIDAZOLE-2-THIONE

Systematic Name

English

Code System Code Type Description

WIKIPEDIA

Mercaptobenzimidazole