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Details

Stereochemistry ABSOLUTE
Molecular Formula C26H34ClN3O4
Molecular Weight 488.019
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of VALEMETOSTAT

SMILES

CN(C)[C@H]1CC[C@@H](CC1)[C@@]2(C)OC3=C(Cl)C=C(C(=O)NCC4=C(C)C=C(C)NC4=O)C(C)=C3O2

InChI

InChIKey=SSDRNUPMYCFXGM-UYPAYLBCSA-N
InChI=1S/C26H34ClN3O4/c1-14-11-15(2)29-25(32)20(14)13-28-24(31)19-12-21(27)23-22(16(19)3)33-26(4,34-23)17-7-9-18(10-8-17)30(5)6/h11-12,17-18H,7-10,13H2,1-6H3,(H,28,31)(H,29,32)/t17-,18-,26-/m1/s1

HIDE SMILES / InChI

Molecular Formula C26H34ClN3O4
Molecular Weight 488.019
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 3 / 3
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Cmax

ValueDoseCo-administeredAnalytePopulation
1500 ng/mL
200 mg 1 times / day multiple, oral
VALEMETOSTAT plasma
Homo sapiens
2230 ng/mL
200 mg single, oral
VALEMETOSTAT plasma
Homo sapiens

AUC

ValueDoseCo-administeredAnalytePopulation
10800 ng × h/mL
200 mg 1 times / day multiple, oral
VALEMETOSTAT plasma
Homo sapiens
18100 ng × h/mL
200 mg single, oral
VALEMETOSTAT plasma
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
20.4 h
200 mg 1 times / day multiple, oral
VALEMETOSTAT plasma
Homo sapiens
9.46 h
200 mg single, oral
VALEMETOSTAT plasma
Homo sapiens

Funbound

ValueDoseCo-administeredAnalytePopulation
10%
200 mg 1 times / day multiple, oral
VALEMETOSTAT plasma
Homo sapiens
Substance Class Chemical
Record UNII
60RD0234VE
Record Status Validated (UNII)
Record Version