THIOSEMICARBAZIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	CH5N3S
Molecular Weight	91.136
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NNC(N)=S

InChI

InChIKey=BRWIZMBXBAOCCF-UHFFFAOYSA-N

InChI=1S/CH5N3S/c2-1(5)4-3/h3H2,(H3,2,4,5)

HIDE SMILES / InChI

Molecular Formula	CH5N3S
Molecular Weight	91.136
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Inactivation of herpes simplex virus by thiosemicarbazones and certain cations.	1974 Apr	15825395
Synthesis, structural characterization and antimicrobial activities of 12 zinc(II) complexes with four thiosemicarbazone and two semicarbazone ligands.	2003 Aug 1	12888265
Synthesis and in vitro antibacterial evaluation of novel imidazo[2',1':5,1]-1,2,4-triazolo[4,3-c]-quinazoline derivatives of 5-thioxo-1, 2, 4-triazole, 4-oxothiazolidine, and their open-chain counterparts.	2003 Dec	14677149
Novel 3,3a,4,5,6,7-hexahydroindazole and arylthiazolylpyrazoline derivatives as anti-inflammatory agents.	2003 Dec	14677148
Oxidative cyclization of D-fructose thiosemicarbazones to 2-amino-5-(D-arabino-1,2,3,4-tetrahydroxybut-1-yl)-1,3,4-thiadiazoles through carbon-carbon bond cleavage of the sugar chain.	2003 Jun	12856995
Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain.	2003 Oct 20	14505663
Structure and immunological activity of disubstituted thiosemicarbazide isoxazole derivative.	2004 Dec	15909949
EPR, magnetic and spectral studies of copper(II) and nickel(II) complexes of schiff base macrocyclic ligand derived from thiosemicarbazide and glyoxal.	2004 Jan	14670471
Interactions between 1-benzoyl-4-p-chlorophenyl thiosemicarbazide and serum albumin: investigation by fluorescence spectroscopy.	2004 Jan 2	14697780
Tetrazolo[1,5-a] quinoline derivatives as anti-inflammatory and antimicrobial agents [1].	2004 Jul-Aug	15881801
Novel aroylhydrazone and thiosemicarbazone iron chelators with anti-malarial activity against chloroquine-resistant and -sensitive parasites.	2004 Mar	14687919
synthesis, characterization and in vitro antiamoebic activity of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazones and their Palladium (II) and Ruthenium (II) complexes.	2004 May	15110972
Phase I and pharmacokinetic study of the ribonucleotide reductase inhibitor, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone, administered by 96-hour intravenous continuous infusion.	2004 May 1	15117978
Effect of bis(acetato)tetrakis(imidazole) copper(II) in delaying the onset and reducing the mortality rate of strychnine- and thiosemicarbazide- induced convulsions.	2004 Oct	15516705
Synthesis and potential antimycotic activity of 4-substituted-3-(thiophene-2-yl-methyl)-Delta2-1,2,4-triazoline-5-thiones.	2004 Sep	15610621
Synthesis and antimicrobial activities of some new 1-(5-phenylamino-[1,3,4]thiadiazol-2-yl)methyl-5-oxo-[1,2,4]triazole and 1-(4-phenyl-5-thioxo-[1,2,4]triazol-3-yl)methyl-5-oxo- [1,2,4]triazole derivatives.	2004 Sep	15337292
Syntheses and evaluation of antioxidant activity of sydnonyl substituted thiazolidinone and thiazoline derivatives.	2004 Sep 1	15358290
In vitro activity and mechanism of action against the protozoan parasite Trypanosoma cruzi of 5-nitrofuryl containing thiosemicarbazones.	2004 Sep 15	15336268
Physical and spectroscopic studies on novel vanadyl complexes of some substituted thiosemicarbazides.	2005 Apr	15741109
Controlled ligand deprotonation in lanthanide chelates with asymmetric semicarbazone/benzoylhydrazone or semicarbazone/thiosemicarbazone coordination spheres.	2005 Aug 8	16060625
Absolute configuration and conformational disorder of a tricyclic thiosemicarbazone derivative.	2005 Dec	16330851
Copper(II) complexes with substituted thiosemicarbazones of thiophene-2-carboxaldehyde: synthesis, characterization and antiamoebic activity against E. histolytica.	2005 Dec	16129515
Spectral studies of coordination compounds of cobalt(II) with thiosemicarbazone of heterocyclic ketone.	2005 Dec	15979935
Organometallic-based antibacterial and antifungal compounds: transition metal complexes of 1,1'-diacetylferrocene-derived thiocarbohydrazone, carbohydrazone, thiosemicarbazone and semicarbazone.	2005 Feb	15895689
Investigation into 64Cu-labeled Bis(selenosemicarbazone) and Bis(thiosemicarbazone) complexes as hypoxia imaging agents.	2005 Feb	15721760
Mono- and dinuclear tricarbonyltechnetium(I) complexes with thiosemicarbazones.	2005 Feb 21	15859256
Spectroscopic, thermal and electrochemical studies on some nickel(II) thiosemicarbazone complexes.	2005 Jan 1	15556446
Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain.	2005 Jan 3	15582423
Synthesis and efficiency of a spherical macroporous epoxy-polyamide chelating resin for preconcentrating and separating trace noble metal ions.	2005 Jan-Feb	15801183
Nickel (II) complexes of naphthaquinone thiosemicarbazone and semicarbazone: synthesis, structure, spectroscopy, and biological activity.	2005 Jul	15927263
Heterometallic compounds assembled from ferrocene-containing bisthiosemicarbazone clips.	2005 Jul 25	16022544
Synthesis and antiamoebic activity of 3,7-dimethyl-pyrazolo[3,4-e][1,2,4] triazin-4-yl thiosemicarbazide derivatives.	2005 Jun	15911221
Thiourea-catalyzed enantioselective cyanosilylation of ketones.	2005 Jun 29	15969569
Benzimidazolyl quinolinyl mercaptotriazoles as potential antimicrobial and antiviral agents.	2005 Mar	15907223
Synthesis of thiosemicarbazone and 4-thiazolidinone derivatives and their in vitro anti-Toxoplasma gondii activity.	2005 May 16	15863319
Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives.	2005 May 2	15809160
Spectroscopic, cyclic voltammetric and biological studies of transition metal complexes with mixed nitrogen-sulphur (NS) donor macrocyclic ligand derived from thiosemicarbazide.	2005 Nov	16174565
Effects on rat testes of the thiosemicarbazone derivative Schiff base (4-(1-phenylmethylcyclobutane-3-yl)-2-(2-hydroxybenzylidenehydrazino)thiazole) and its cadmium(II) complex.	2005 Nov-Dec	15540255
Electrochemical and ESR study of 5-nitrofuryl-containing thiosemicarbazones antiprotozoal drugs.	2005 Oct	16165034
Synthesis and spectroscopic study on photochromism of a new thiosemicarbazone compound containing pyrazolone.	2005 Sep	16043052
Chiral binaphthyl-derived amine-thiourea organocatalyst-promoted asymmetric Morita-Baylis-Hillman reaction.	2005 Sep 15	16146410
Bonding trends of thiosemicarbazones in mononuclear and dinuclear copper(I) complexes: syntheses, structures, and theoretical aspects.	2006 Feb 20	16471964
Rhodium assisted C-H activation of benzaldehyde thiosemicarbazones and their oxidation via activation of molecular oxygen.	2006 Feb 6	16441137
Synthesis of 5-phenyl-1-(3-pyridyl)-1H-1,2,4-triazole-3-carboxylic acid derivatives of potential anti-inflammatory activity.	2006 Jan	16411174
Benzoin 4-ethylthiosemicarbazone.	2006 Jan	16397328
Structural and spectral perspectives of a novel thiosemicarbazone synthesized from di-2-pyridyl ketone and 4-phenyl-3-thiosemicarbazide.	2006 Jan	16344250
Synthesis, docking, and in vitro activity of thiosemicarbazones, aminoacyl-thiosemicarbazides and acyl-thiazolidones against Trypanosoma cruzi.	2006 Jun 1	16458521
Analgesic and anticonvulsant effects of extracts from the leaves of Kalanchoe crenata (Andrews) Haworth (Crassulaceae).	2006 Jun 15	16423479
Manganese(II) complexes of substituted di-2-pyridyl ketone thiosemicarbazones: structural and spectral studies.	2006 May 1	16098800
Antioxidant, pro-oxidant effect of the thiosemicarbazone derivative Schiff base (4-(1-phenylmethylcyclobutane-3-yl)-2-(2-hydroxybenzylidenehydrazino) thiazole) and its metal complexes on rats.	2006 Nov-Dec	16143962

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:32:27 GMT 2023` Edited by `admin` on `Fri Dec 15 17:32:27 GMT 2023`
Record UNII	6056O8W6ET
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

THIOSEMICARBAZIDE

Systematic Name

English

THIOCARBAMOYL HYDRAZIDE

Common Name

English

THIOSEMICARBAZIDE [MI]

Common Name

English

1-AMINO-2-THIOUREA [HSDB]

Common Name

English

3-THIOSEMICARBAZIDE

Systematic Name

English

N-AMINOTHIOUREA

Systematic Name

English

HYDRAZINECARBOTHIOAMIDE

Systematic Name

English

NSC-2213

Code

English

Code System Code Type Description

ECHA (EC/EINECS)

201-184-7