RIBUVAPTAN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C23H20ClF6N5O5
Molecular Weight	595.879
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=O)OC[C@H](NC(=O)CN1N=C(N(C[C@H](O)C(F)(F)F)C1=O)C2=CC=C(Cl)C=C2)C3=CC=CC(=C3)C(F)(F)F

InChI

InChIKey=JYRCFPAYSZZCBP-IRXDYDNUSA-N

InChI=1S/C23H20ClF6N5O5/c24-15-6-4-12(5-7-15)19-33-35(21(39)34(19)9-17(36)23(28,29)30)10-18(37)32-16(11-40-20(31)38)13-2-1-3-14(8-13)22(25,26)27/h1-8,16-17,36H,9-11H2,(H2,31,38)(H,32,37)/t16-,17-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C23H20ClF6N5O5
Molecular Weight	595.879
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://adisinsight.springer.com/drugs/800035638 | https://apps.who.int/iris/bitstream/handle/10665/275695/WHO-EMP-RHT-TSN-2018.1-eng.pdf

Ribuvaptan (BAY 868050) is a vasopressin receptor antagonist that has been developed for treatment of heart failure. No information on current use is available.

Originator

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:47:05 UTC 2023` Edited by `admin` on `Sat Dec 16 09:47:05 UTC 2023`
Record UNII	6004MB8Y0D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RIBUVAPTAN

Official Name

English

ribuvaptan [INN]

Common Name

English

Ribuvaptan [WHO-DD]

Common Name

English

1H-1,2,4-TRIAZOLE-1-ACETAMIDE, N-((1R)-2-((AMINOCARBONYL)OXY)-1-(3-(TRIFLUOROMETHYL)PHENYL)ETHYL)-3-(4-CHLOROPHENYL)-4,5-DIHYDRO-5-OXO-4-((2S)-3,3,3-TRIFLUORO-2-HYDROXYPROPYL)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2180