DELDEPREVIR

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C45H56F2N6O8S2
Molecular Weight	911.088
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12C[C@]1(NC(=O)[C@]3([H])C[C@H](CN3C(=O)[C@@H](CC(=O)N4CCCC(F)(F)C4)CCCCCC=C2)OC5=CC(=NC6=C(C)C(OC)=CC=C56)C7=NC(=CS7)C(C)C)C(=O)NS(=O)(=O)C8CC8

InChI

InChIKey=UDMJANYPQWEDFT-ZAWFUYGJSA-N

InChI=1S/C45H56F2N6O8S2/c1-26(2)34-24-62-41(49-34)33-21-37(32-15-16-36(60-4)27(3)39(32)48-33)61-30-20-35-40(55)50-45(43(57)51-63(58,59)31-13-14-31)22-29(45)12-9-7-5-6-8-11-28(42(56)53(35)23-30)19-38(54)52-18-10-17-44(46,47)25-52/h9,12,15-16,21,24,26,28-31,35H,5-8,10-11,13-14,17-20,22-23,25H2,1-4H3,(H,50,55)(H,51,57)/b12-9-/t28-,29-,30-,35+,45-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C45H56F2N6O8S2
Molecular Weight	911.088
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.sciencedirect.com/science/article/abs/pii/S0168827813608491 | https://www.ncbi.nlm.nih.gov/pubmed/24735613 | https://adisinsight.springer.com/drugs/800034265

Deldeprevir (Neceprevir) is a direct-acting anti-HCV drug developed by Achillion. Deldeprevir acts by inhibition of the viral NS3/4A protease. In phase 1b clinical trial for the treatment of chronic HCV infection, the drug was safe and well-tolerated and produced more than a 3 log10 mean maximum reduction in plasma HCV RNA levels in all treated groups. Despite positive results, no development of the drug was reported by Achillion since 2014.

Originator

Approval Year

PubMed

Title	Date	PubMed
Current race in the development of DAAs (direct-acting antivirals) against HCV.	2014 Jun 15	24735613

Substance Class	Chemical Created by `admin` on `Sat Dec 16 02:10:30 UTC 2023` Edited by `admin` on `Sat Dec 16 02:10:30 UTC 2023`
Record UNII	5ZT4SBY0BD
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DELDEPREVIR

Official Name

English

NECEPREVIR

Common Name

English

Deldeprevir [WHO-DD]

Common Name

English

ACH-0142684

Code

English

ACH-2684

Code

English

DELDEPREVIR [USAN]

Common Name

English

deldeprevir [INN]

Common Name

English

Code System Code Type Description

SMS_ID

300000034165