Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C45H56F2N6O8S2 |
| Molecular Weight | 911.088 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12C[C@]1(NC(=O)[C@]3([H])C[C@H](CN3C(=O)[C@@H](CC(=O)N4CCCC(F)(F)C4)CCCCCC=C2)OC5=CC(=NC6=C(C)C(OC)=CC=C56)C7=NC(=CS7)C(C)C)C(=O)NS(=O)(=O)C8CC8
InChI
InChIKey=UDMJANYPQWEDFT-ZAWFUYGJSA-N
InChI=1S/C45H56F2N6O8S2/c1-26(2)34-24-62-41(49-34)33-21-37(32-15-16-36(60-4)27(3)39(32)48-33)61-30-20-35-40(55)50-45(43(57)51-63(58,59)31-13-14-31)22-29(45)12-9-7-5-6-8-11-28(42(56)53(35)23-30)19-38(54)52-18-10-17-44(46,47)25-52/h9,12,15-16,21,24,26,28-31,35H,5-8,10-11,13-14,17-20,22-23,25H2,1-4H3,(H,50,55)(H,51,57)/b12-9-/t28-,29-,30-,35+,45-/m1/s1
| Molecular Formula | C45H56F2N6O8S2 |
| Molecular Weight | 911.088 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Deldeprevir (Neceprevir) is a direct-acting anti-HCV drug developed by Achillion. Deldeprevir acts by inhibition of the viral NS3/4A protease. In phase 1b clinical trial for the treatment of chronic HCV infection, the drug was safe and well-tolerated and produced more than a 3 log10 mean maximum reduction in plasma HCV RNA levels in all treated groups. Despite positive results, no development of the drug was reported by Achillion since 2014.
Originator
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 02:10:30 GMT 2023
by
admin
on
Sat Dec 16 02:10:30 GMT 2023
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| Record UNII |
5ZT4SBY0BD
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| Record Status |
Validated (UNII)
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| Record Version |
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300000034165
Created by
admin on Sat Dec 16 02:10:30 GMT 2023 , Edited by admin on Sat Dec 16 02:10:30 GMT 2023
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CHEMBL3040582
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admin on Sat Dec 16 02:10:30 GMT 2023 , Edited by admin on Sat Dec 16 02:10:30 GMT 2023
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56935739
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1229626-28-1
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YY-152
Created by
admin on Sat Dec 16 02:10:30 GMT 2023 , Edited by admin on Sat Dec 16 02:10:30 GMT 2023
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C166876
Created by
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5ZT4SBY0BD
Created by
admin on Sat Dec 16 02:10:30 GMT 2023 , Edited by admin on Sat Dec 16 02:10:30 GMT 2023
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9600
Created by
admin on Sat Dec 16 02:10:30 GMT 2023 , Edited by admin on Sat Dec 16 02:10:30 GMT 2023
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