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Details

Stereochemistry ACHIRAL
Molecular Formula Co.O4S.H2O
Molecular Weight 173.011
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of COBALT SULFATE MONOHYDRATE

SMILES

O.[Co++].[O-]S([O-])(=O)=O

InChI

InChIKey=BGORGFZEVHFAQU-UHFFFAOYSA-L
InChI=1S/Co.H2O4S.H2O/c;1-5(2,3)4;/h;(H2,1,2,3,4);1H2/q+2;;/p-2

HIDE SMILES / InChI
Molecular Formula Co
Molecular Weight 58.9332
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula HO4S
Molecular Weight 97.071
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/104729ISBN 9780873715980, Foden C.R., Weddell J.L., 'Hazardous Materials: Emergency Action Data' (1991), Retrieved from https://books.google.com/books?id=4IPE8Pjhm8UC&pgISBN: 978-94-010-7024-9, Matar M.S., Mirbach M.J.,Tayim H.A. 'Catalysis in Petrochemical Processes' (1988), p.136, Retrieved from https://books.google.com/books?id=MkD2JnDkZYYC&dqhttp://aygrt.isrj.org/colorArticles/4972.pdfhttp://onlinelibrary.wiley.com/doi/10.1002/3527600418.mb744048e0023/pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27527840https://fscimage.fishersci.com/msds/05330.htmhttp://laboratorychemicals.in/uploads/msds/10026-17-2-49128.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/2253206https://monographs.iarc.fr/ENG/Monographs/vol52/mono52-16.pdfhttp://datasheets.scbt.com/sc-227251.pdf
Curator's Comment: description was created based on several sources, including: DOI:10.1080/00958970802416020 | DOI:10.1080/00958972.2010.521553 | https://www.ncbi.nlm.nih.gov/pubmed/7201957 | https://www.ncbi.nlm.nih.gov/pubmed/18475879

Cobaltous iodide is a catalyst used in organic synthesis.

Originator

Brandt, G.
20
Curator's Comment: Cobalt was discovered by Georg Brandt, a Swedish chemist, in 1739.

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Hypoxia-inducible factor 1-alpha inhibitor
22
Target ID: Q9NWT6
Gene ID: 55662.0
Gene Symbol: HIF1AN
Target Organism: Homo sapiens (Human)
Inhibitor
8297
 1.0 µM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Withdrawn
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Cobalt iontophoresis techniques for tracing afferent and efferent connections in the vertebrate CNS.
1975 May 2
Improved methods for cobalt filling and silver intensification of insect motor neurons.
1982 Jul
Acute oral toxicity of inorganic cobalt compounds in rats.
1982 Jun
Inhalation toxicity studies of cobalt sulfate in F344/N rats and B6C3F1 mice.
1990 Aug
Synthesis and Anti-Candida Activity of Cobalt(II) Complexes of Benzene-1,2-Dioxyacetic Acid (bdoaH(2)). X-Ray Crystal Structures of [Co(bdoa)(H(2)O)(3)] 3.5H(2)O and {[CO(phen)(3)](bdoa)}(2)24H(2)O (phen = 1,10-Phenanthroline).
1999
In vitro assessment of cobalt oxide particle toxicity: identifying and circumventing interference.
2013 Sep
Patents

Patents

US20150010463
20
US3459677 A
20
US4326084
20
US5718844
20
US6740618 B2
20
WO2014127808A1
20

Sample Use Guides

In Vivo Use Guide
For treatment of anemia, oral cobal chloride was administered at doses 25 mg and 50 mg daily.
Route of Administration: Oral
In Vitro Use Guide
HIF asparaginyl hydroxylase activity was measured by a method based on the hydroxylation coupled decarboxylation of 2-oxoglutarate with the synthetic HIF-1α peptides in the presence of varying concentrations of Co (1-5 uM). Ki for HIF asparaginyl hydroxylase was 1uM.
Substance Class Chemical
Created
by admin
on Sat Dec 16 08:36:33 GMT 2023
Edited
by admin
on Sat Dec 16 08:36:33 GMT 2023
Record UNII
5ZQA69KLC0
Record Status Validated (UNII)
Record Version
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Name Type Language
COBALT SULFATE MONOHYDRATE
Systematic Name English
COBALT MESOSULFATE (COH2SO5)
Common Name English
COBALT(II) SULFATE MONOHYDRATE
Systematic Name English
COBALT SULFATE (COSO4) MONOHYDRATE
Common Name English
SULFURIC ACID, COBALT(2+) SALT (1:1), MONOHYDRATE
Systematic Name English
Code System Code Type Description
CAS
13455-34-0
Created by admin on Sat Dec 16 08:36:33 GMT 2023 , Edited by admin on Sat Dec 16 08:36:33 GMT 2023
PRIMARY
FDA UNII
5ZQA69KLC0
Created by admin on Sat Dec 16 08:36:33 GMT 2023 , Edited by admin on Sat Dec 16 08:36:33 GMT 2023
PRIMARY
SMS_ID
100000176894
Created by admin on Sat Dec 16 08:36:33 GMT 2023 , Edited by admin on Sat Dec 16 08:36:33 GMT 2023
PRIMARY
EPA CompTox
DTXSID001026257
Created by admin on Sat Dec 16 08:36:33 GMT 2023 , Edited by admin on Sat Dec 16 08:36:33 GMT 2023
PRIMARY
PUBCHEM
16210984
Created by admin on Sat Dec 16 08:36:33 GMT 2023 , Edited by admin on Sat Dec 16 08:36:33 GMT 2023
PRIMARY
NIH
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