NUSINERSEN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 09:13:16 GMT 2023` Edited by `admin` on `Sat Dec 16 09:13:16 GMT 2023`
Nucleic Acid Subtype
Sequence Type	COMPLETE
Record UNII	5Z9SP3X666
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

NUSINERSEN

Official Name

English

RNA, (2'-0-(2-METHOXYETHYI))(P-THIO)(M5U-C-A-C-M5U-M5U-M5U-C-A-M5UA- A-M5 U-G-C-M5U-G-G)

Common Name

English

nusinersen [INN]

Common Name

English

Nusinersen [WHO-DD]

Common Name

English

NUSINERSEN [USAN]

Common Name

English

ISIS-396443

Code

English

BIIB058

Code

English

NUSINERSEN [MI]

Common Name

English

BIIB-058

Code

English

ISIS 396443

Code

English

Classification Tree Code System Code

NDF-RT

N0000191626

Created by admin on Sat Dec 16 09:13:16 GMT 2023 , Edited by admin on Sat Dec 16 09:13:16 GMT 2023

FDA ORPHAN DRUG

336711

Created by admin on Sat Dec 16 09:13:16 GMT 2023 , Edited by admin on Sat Dec 16 09:13:16 GMT 2023

WHO-ATC

M09AX07

Created by admin on Sat Dec 16 09:13:16 GMT 2023 , Edited by admin on Sat Dec 16 09:13:16 GMT 2023

NDF-RT

N0000193222

Created by admin on Sat Dec 16 09:13:16 GMT 2023 , Edited by admin on Sat Dec 16 09:13:16 GMT 2023

Code System Code Type Description

DRUG CENTRAL

5207

Created by admin on Sat Dec 16 09:13:16 GMT 2023 , Edited by admin on Sat Dec 16 09:13:16 GMT 2023

PRIMARY

MERCK INDEX

m11974

Created by admin on Sat Dec 16 09:13:16 GMT 2023 , Edited by admin on Sat Dec 16 09:13:16 GMT 2023

PRIMARY

INN

10003

Created by admin on Sat Dec 16 09:13:16 GMT 2023 , Edited by admin on Sat Dec 16 09:13:16 GMT 2023

PRIMARY

ChEMBL

CHEMBL3301572

Created by admin on Sat Dec 16 09:13:16 GMT 2023 , Edited by admin on Sat Dec 16 09:13:16 GMT 2023

PRIMARY

RXCUI

1863556

Created by admin on Sat Dec 16 09:13:16 GMT 2023 , Edited by admin on Sat Dec 16 09:13:16 GMT 2023

PRIMARY

WIKIPEDIA

NUSINERSEN

Created by admin on Sat Dec 16 09:13:16 GMT 2023 , Edited by admin on Sat Dec 16 09:13:16 GMT 2023

PRIMARY

USAN

AB-110

Created by admin on Sat Dec 16 09:13:16 GMT 2023 , Edited by admin on Sat Dec 16 09:13:16 GMT 2023

PRIMARY

DAILYMED

5Z9SP3X666

Created by admin on Sat Dec 16 09:13:16 GMT 2023 , Edited by admin on Sat Dec 16 09:13:16 GMT 2023

PRIMARY

FDA UNII

5Z9SP3X666

Created by admin on Sat Dec 16 09:13:16 GMT 2023 , Edited by admin on Sat Dec 16 09:13:16 GMT 2023

PRIMARY

NCI_THESAURUS

C166875

Created by admin on Sat Dec 16 09:13:16 GMT 2023 , Edited by admin on Sat Dec 16 09:13:16 GMT 2023

PRIMARY

EVMPD

SUB182823

Created by admin on Sat Dec 16 09:13:16 GMT 2023 , Edited by admin on Sat Dec 16 09:13:16 GMT 2023

PRIMARY

EPA CompTox

DTXSID301027785

Created by admin on Sat Dec 16 09:13:16 GMT 2023 , Edited by admin on Sat Dec 16 09:13:16 GMT 2023

PRIMARY

DRUG BANK

DB13161

Created by admin on Sat Dec 16 09:13:16 GMT 2023 , Edited by admin on Sat Dec 16 09:13:16 GMT 2023

PRIMARY

CAS

1258984-36-9

Created by admin on Sat Dec 16 09:13:16 GMT 2023 , Edited by admin on Sat Dec 16 09:13:16 GMT 2023

PRIMARY

Sugar	Site Range	Site Count
2-O-beta-hydroxy-ethoxy-methyl Ribose (Qiagen)	1_1-1_18	18 / 18

Linkage	Site Range	Site Count
Phosporothioate	1_2-1_18	17 / 17

Related Record Type Details


					4CHB7QQU1Q

NUSINERSEN SODIUM

SALT/SOLVATE -> PARENT

Related Record Type Details


					5Z9SP3X666

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
BASE SUBSTITUTION	[1_2] [1_4] [1_8] [1_15]		CYTOSINE		5-METHYLCYTOSINE	6R795CQT4H

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER	CHEMICAL