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NUSINERSEN
5Z9SP3X666
US Approved Rx (2016)
First approved in 2016
General
Record Details
Names
10
Classification
4
Identifiers
14
Subunits
1
Sugars
1
Linkages
1
Relationships
1
Active Moiety
1
Modifications
1
Characteristic Attributes
1
NUSINERSEN
5Z9SP3X666
US Approved Rx (2016)
First approved in 2016
General
Approval Year
2016
495
Record Details
Substance Class
Nucleic Acid
Nucleic Acid Subtype
Sequence Type
COMPLETE
Record UNII
5Z9SP3X666
Record Status
Validated (UNII)
Record Version
22
21
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19
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17
16
15
14
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10
9
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Names
10
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entries
Name
Type
Language
Name
Type
Language
NUSINERSEN
Official Name
English
RNA, (2'-0-(2-METHOXYETHYI))(P-THIO)(M5U-C-A-C-M5U-M5U-M5U-C-A-M5UA- A-M5 U-G-C-M5U-G-G)
Common Name
English
nusinersen [INN]
Common Name
English
Nusinersen [WHO-DD]
Common Name
English
NUSINERSEN [USAN]
Common Name
English
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Classification
4
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Classification Tree
Code System
Code
Classification Tree
Code System
Code
Established Pharmacologic Class
Established Pharmacologic Class
[EPC]
Antisense Oligonucleotide
[EPC]
NDF-RT
N0000191626
Designated/Approved
ORPHAN DRUG
Designated/Approved
Treatment of spinal muscular atrophy
FDA ORPHAN DRUG
336711
Other drugs for disorders of the musculo-skeletal system
ATC
MUSCULO-SKELETAL SYSTEM
OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM
OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM
Other drugs for disorders of the musculo-skeletal system
nusinersen
WHO-ATC
M09AX07
Established Pharmacologic Class
Established Pharmacologic Class
[EPC]
Survival Motor Neuron-2-directed RNA Interaction
[EPC]
NDF-RT
N0000193222
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Identifiers
14
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Code System
Code
Type
Description
Code System
Code
Type
Description
DRUG CENTRAL
5207
PRIMARY
MERCK INDEX
m11974
PRIMARY
INN
10003
PRIMARY
ChEMBL
CHEMBL3301572
PRIMARY
RXCUI
1863556
PRIMARY
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Subunits
1
Subunit 0
>SUBUNIT_0
Sugars
1
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Sugar
Site Range
Site Count
Sugar
Site Range
Site Count
2-O-beta-hydroxy-ethoxy-methyl Ribose (Qiagen)
1_1-1_18
18 / 18
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Linkages
1
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Linkage
Site Range
Site Count
Linkage
Site Range
Site Count
Phosporothioate
1_2-1_18
17 / 17
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Relationships
1
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Related Record
Type
Details
Related Record
Type
Details
4CHB7QQU1Q
NUSINERSEN SODIUM
SALT/SOLVATE -> PARENT
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Active Moiety
1
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Related Record
Type
Details
Related Record
Type
Details
5Z9SP3X666
NUSINERSEN
ACTIVE MOIETY
Showing 1 to 1 of 1 entries
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Modifications
1
Structural Modifications
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entries
Modification Type
Location Site
Location Type
Residue Modified
Extent
Fragment Name
Fragment Approval
Modification Type
Location Site
Location Type
Residue Modified
Extent
Fragment Name
Fragment Approval
BASE SUBSTITUTION
[1_2] [1_4] [1_8] [1_15]
CYTOSINE
5-METHYLCYTOSINE
6R795CQT4H
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Characteristic Attributes
1
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entries
Name
Property Type
Amount
Referenced Substance
Defining
Parameters
References
Name
Property Type
Amount
Referenced Substance
Defining
Parameters
References
MOL_WEIGHT:NUMBER
CHEMICAL
NUMBER 7127 Da (average)
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