XALNESIRAN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 16:57:25 UTC 2023` Edited by `admin` on `Sat Dec 16 16:57:25 UTC 2023`
Nucleic Acid Type	RNAI
Nucleic Acid Subtype
Sequence Type	COMPLETE
Record UNII	5Z657QHG6F
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

XALNESIRAN

Official Name

English

RO7445482 FREE ACID

Common Name

English

XALNESIRAN [USAN]

Common Name

English

xalnesiran [INN]

Common Name

English

RO-7445482 FREE ACID

Common Name

English

RNA, (Gm-sp-Am-(2′-deoxy-2′-fluoro)C-Am-Am-Am-Am-(2′-deoxy-2′-fluoro)A-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-Cm-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-Am-Cm-Am-(2′-deoxy-2′-fluoro)A-Um-Am-Am-Gm-Cm-Am-Gm-Cm-Cm-[2′-

Common Name

English

DCR-A1AT FREE ACID

Common Name

English

RG-6346 FREE ACID

Common Name

English

DCR-HBVS FREE ACID

Common Name

English

DCR-S219 FREE ACID

Code

English

Code System Code Type Description

INN

12051

Created by admin on Sat Dec 16 16:57:25 UTC 2023 , Edited by admin on Sat Dec 16 16:57:25 UTC 2023

PRIMARY

CAS

2538784-48-2

Created by admin on Sat Dec 16 16:57:25 UTC 2023 , Edited by admin on Sat Dec 16 16:57:25 UTC 2023

PRIMARY

USAN

LM-23

Created by admin on Sat Dec 16 16:57:25 UTC 2023 , Edited by admin on Sat Dec 16 16:57:25 UTC 2023

PRIMARY

NCI_THESAURUS

C188516

Created by admin on Sat Dec 16 16:57:25 UTC 2023 , Edited by admin on Sat Dec 16 16:57:25 UTC 2023

PRIMARY

FDA UNII

5Z657QHG6F

Created by admin on Sat Dec 16 16:57:25 UTC 2023 , Edited by admin on Sat Dec 16 16:57:25 UTC 2023

PRIMARY

Sugar	Site Range	Site Count
2'-Fluoro-Ribose	1_3;1_8-1_10;1_12-1_13;1_17;2_2-2_3;2_5;2_7-2_8;2_10;2_12;2_14;2_16;2_19	17 / 58
2'-O-Methyl-Ribose	1_1-1_2;1_4-1_7;1_11;1_14-1_16;1_18-1_36;2_1;2_4;2_6;2_9;2_11;2_13;2_15;2_17-2_18;2_20-2_22	41 / 58

Linkage	Site Range	Site Count
Phosphate	1_3-1_36;2_5-2_20	50 / 56
Phosporothioate	1_2;2_2-2_4;2_21-2_22	6 / 56

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ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE_SUBSTITUTION	[1_27]	SITE_SPECIFIC			UNSPECIFIED SUBSTANCE	4b489b28 (not in database)
NUCLEOSIDE_SUBSTITUTION	[1_28] [1_29] [1_30]	SITE_SPECIFIC			UNSPECIFIED SUBSTANCE	3a625511 (not in database)
NUCLEOTIDE SUBSTITUTION	[2_1]	5'-TERMINUS			UNSPECIFIED SUBSTANCE	55513d6d (not in database)