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Details

Stereochemistry RACEMIC
Molecular Formula C22H27N3O4.ClH
Molecular Weight 433.928
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIPERODON HYDROCHLORIDE

SMILES

Cl.O=C(NC1=CC=CC=C1)OCC(CN2CCCCC2)OC(=O)NC3=CC=CC=C3

InChI

InChIKey=OWULVAZDMWJBLB-UHFFFAOYSA-N
InChI=1S/C22H27N3O4.ClH/c26-21(23-18-10-4-1-5-11-18)28-17-20(16-25-14-8-3-9-15-25)29-22(27)24-19-12-6-2-7-13-19;/h1-2,4-7,10-13,20H,3,8-9,14-17H2,(H,23,26)(H,24,27);1H

HIDE SMILES / InChI
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C22H27N3O4
Molecular Weight 397.4675
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description
Curator's Comment: https://books.google.ru/books?id=GEXMBQAAQBAJ&pg=PA126&lpg=PA126&dq=diperodon+hemorrhoids&source=bl&ots=bCxlkt8R8h&sig=WdZ_xvaAZOgtxGZ2fAgci9gfLh0&hl=ru&sa=X&ved=0ahUKEwjT0uyqqpXMAhVHQZoKHb3YDBgQ6AEIHzAA#v=onepage&q=diperodon%20hemorrhoids&f=false https://www.ncbi.nlm.nih.gov/pubmed/12367714 https://books.google.ru/books?id=07g30rxCA0EC&pg=PA112&lpg=PA112&dq=diperodon+was+discovered&source=bl&ots=KjNHtaThll&sig=8zuZga1hLvXSs0x_oezYLJkx02M&hl=ru&sa=X&ved=0ahUKEwiOxbXetZXMAhXJDywKHeqwACAQ6AEIPjAF#v=onepage&q=diperodon%20was%20discovered&f=false

Diperodon is one of several phenylurethane derivatives of dialkyl amino alcohols which have demonstrated significant local anaesthetic activity.

Approval Year

1937
60
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Unknown

Approved Use

Unknown
Primary
Approved
8429
Unknown

Approved Use

Unknown
Doses

Doses

DosePopulationAdverse events​
1 % multiple, topical
Dose: 1 %
Route: topical
Route: multiple
Dose: 1 %
Sources:
https://pubmed.ncbi.nlm.nih.gov/7418402/
unhealthy, 30
n = 1
Health Status: unhealthy
Condition: psoriasis
Age Group: 30
Sex: M
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/7418402/
Other AEs: Allergy...
Other AEs:
Allergy
Sources:
https://pubmed.ncbi.nlm.nih.gov/7418402/
AEs

AEs

AESignificanceDosePopulation
Allergy
1 % multiple, topical
Dose: 1 %
Route: topical
Route: multiple
Dose: 1 %
Sources:
https://pubmed.ncbi.nlm.nih.gov/7418402/
unhealthy, 30
n = 1
Health Status: unhealthy
Condition: psoriasis
Age Group: 30
Sex: M
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/7418402/
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer
Nav1.7
36
Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
Nav1.7
36
 yes
Sourcing

Sourcing

Vendor/AggregatorIDURL
001 Chemical
DY501456
https://www.001chemical.com/chem/101-08-6
3B Scientific (Wuhan) Corp
3B2-1097
http://www.3bsc.com/index/pro_info.php?id=54813
AHH Chemical co.,ltd
MT-50443
http://www.ahhchemical.com/product/MT-50443.html
ChemMol
30105076
http://www.chemmol.com/chemmol/30105076.html
Finetech
FT-0750853
http://www.finetechnology-ind.com/prod/detail/pub/101-08-6.html
LGC Standards
LGCFOR3054.01
https://www.lgcstandards.com/US/en/p/LGCFOR3054.01
LGC Standards
MM3054.01
https://www.lgcstandards.com/US/en/p/MM3054.01
Molcore
MC501456
https://www.molcore.com/product/101-08-6
Smolecule
S581436
https://www.smolecule.com/products/s581436
THE BioTek
bt-369759
https://www.thebiotek.com/product/others/bt-369759
mcule
MCULE-2970996429
https://mcule.com/MCULE-2970996429/
PubMed

PubMed

TitleDatePubMed
In vitro study of enzymatic hydrolysis of diperodon enantiomers in blood serum by two-dimensional LC.
2002 Oct 15
Patents

Patents

US2004132
3

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:02:42 GMT 2023
Edited
by admin
on Fri Dec 15 15:02:42 GMT 2023
Record UNII
5YZ5R8I73Y
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DIPERODON HYDROCHLORIDE
GREEN BOOK   MART.   MI   VANDF   WHO-DD  
Common Name English
DIPERODON HYDROCHLORIDE [GREEN BOOK]
Common Name English
DIPERODON HYDROCHLORIDE [MART.]
Common Name English
DIPERODON HYDROCHLORIDE [VANDF]
Common Name English
DIPERODON HYDROCHLORIDE [MI]
Common Name English
DIOTHANE HYDROCHLORIDE
Brand Name English
PROCTODON
Brand Name English
NSC-76069
Code English
DIPERODON HCL
Common Name English
Diperodon hydrochloride [WHO-DD]
Common Name English
1,2-PROPANEDIOL, 3-(1-PIPERIDINYL)-, 1,2-BIS(N-PHENYLCARBAMATE), HYDROCHLORIDE (1:1)
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C245
Created by admin on Fri Dec 15 15:02:42 GMT 2023 , Edited by admin on Fri Dec 15 15:02:42 GMT 2023
Code System Code Type Description
MERCK INDEX
m148
Created by admin on Fri Dec 15 15:02:42 GMT 2023 , Edited by admin on Fri Dec 15 15:02:42 GMT 2023
PRIMARY Merck Index
ECHA (EC/EINECS)
208-659-8
Created by admin on Fri Dec 15 15:02:42 GMT 2023 , Edited by admin on Fri Dec 15 15:02:42 GMT 2023
PRIMARY
SMS_ID
100000079254
Created by admin on Fri Dec 15 15:02:42 GMT 2023 , Edited by admin on Fri Dec 15 15:02:42 GMT 2023
PRIMARY
EVMPD
SUB13620MIG
Created by admin on Fri Dec 15 15:02:42 GMT 2023 , Edited by admin on Fri Dec 15 15:02:42 GMT 2023
PRIMARY
NCI_THESAURUS
C75091
Created by admin on Fri Dec 15 15:02:42 GMT 2023 , Edited by admin on Fri Dec 15 15:02:42 GMT 2023
PRIMARY
PUBCHEM
10830
Created by admin on Fri Dec 15 15:02:42 GMT 2023 , Edited by admin on Fri Dec 15 15:02:42 GMT 2023
PRIMARY
DRUG BANK
DBSALT001677
Created by admin on Fri Dec 15 15:02:42 GMT 2023 , Edited by admin on Fri Dec 15 15:02:42 GMT 2023
PRIMARY
ChEMBL
CHEMBL2109119
Created by admin on Fri Dec 15 15:02:42 GMT 2023 , Edited by admin on Fri Dec 15 15:02:42 GMT 2023
PRIMARY
CAS
537-12-2
Created by admin on Fri Dec 15 15:02:42 GMT 2023 , Edited by admin on Fri Dec 15 15:02:42 GMT 2023
PRIMARY
FDA UNII
5YZ5R8I73Y
Created by admin on Fri Dec 15 15:02:42 GMT 2023 , Edited by admin on Fri Dec 15 15:02:42 GMT 2023
PRIMARY
RXCUI
133043
Created by admin on Fri Dec 15 15:02:42 GMT 2023 , Edited by admin on Fri Dec 15 15:02:42 GMT 2023
PRIMARY RxNorm
EPA CompTox
DTXSID1045324
Created by admin on Fri Dec 15 15:02:42 GMT 2023 , Edited by admin on Fri Dec 15 15:02:42 GMT 2023
PRIMARY
NSC
76069
Created by admin on Fri Dec 15 15:02:42 GMT 2023 , Edited by admin on Fri Dec 15 15:02:42 GMT 2023
PRIMARY
Related Record Type Details
Structure of DIPERODON ANHYDROUS
PARENT -> SALT/SOLVATE
Structure of DIPERODON HYDROCHLORIDE, (S)-
ENANTIOMER -> RACEMATE
Structure of DIPERODON HYDROCHLORIDE, (R)-
ENANTIOMER -> RACEMATE
Related Record Type Details
Structure of DIPERODON ANHYDROUS
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